DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nep4 and ECEL1

DIOPT Version :9

Sequence 1:	NP_650904.3	Gene:	Nep4 / 42449	FlyBaseID:	FBgn0038818	Length:	1040	Species:	Drosophila melanogaster
Sequence 2:	NP_004817.2	Gene:	ECEL1 / 9427	HGNCID:	3147	Length:	775	Species:	Homo sapiens

Alignment Length:	790	Identity:	251/790 - (31%)
Similarity:	383/790 - (48%)	Gaps:	135/790 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   263 AKTMKRYMDNKVDPCVDFYKYACGNWERLHPIPKDKAGFDTFEMLRESLDLVLRNLLEKNTPVHS 327
            |:.:...:|..:|||.|||.:|||.|.|.|.||.||..:.|...:.|..:..||.||.:
Human   109 ARFLAANLDASIDPCQDFYSFACGGWLRRHAIPDDKLTYGTIAAIGEQNEERLRRLLAR------ 167

  Fly   328 AAELRKSPVRNTLFKLNEQGEGEGEADQAAELTAERLRRHIVSKRQLLNRVLVRYKRYTNGTKRK 392
                              .|.|.|.|
Human   168 ------------------PGGGPGGA--------------------------------------- 175

  Fly   393 RLIETPRERTKEEEAAPPVVLPKDKTKDKSDNEEQLHVPTDFLKPHQDAQLKAKNLYRSCVNSAV 457
                                                            ||.|.:..:|||::...
Human   176 ------------------------------------------------AQRKVRAFFRSCLDMRE 192

  Fly   458 LAKRGLEPLHTLIRELGGW--------PVLESQWSESNFNWQVLAATLRRYNNDILIVQWVGADI 514
            :.:.|..|:..:|.:.|||        |.:.::|..:...::....    |:...|....|..|.
Human   193 IERLGPRPMLEVIEDCGGWDLGGAEERPGVAARWDLNRLLYKAQGV----YSAAALFSLTVSLDD 253

  Fly   515 KNSEENIVQFDQTGLGLPTREYFL--QPSNAKYLQAYQRYMAEVMHKMGASKADAQRVASELVAF 577
            :||...:::.||.||.||.|..:|  ...:.|.|.||:.:|..|:..:||...:.:  |.|::..
Human   254 RNSSRYVIRIDQDGLTLPERTLYLAQDEDSEKILAAYRVFMERVLSLLGADAVEQK--AQEILQV 316

  Fly   578 ETQLAGITAPA--EQRLNVTKLYKRMTLDQLQAVVPEIKWRAYLQSLQDREVLGTEEVVIYAVEY 640
            |.|||.||...  :.|.:|:.:|.::||.|||.:.|.::|:..|..:...:....||||:.|.:|
Human   317 EQQLANITVSEHDDLRRDVSSMYNKVTLGQLQKITPHLRWKWLLDQIFQEDFSEEEEVVLLATDY 381

  Fly   641 MSKLVTLLDETDPRTVSNYMMWRFVRHRINNVDDRFDDIKQSFYHALFGREESPQRWKVCIAQVN 705
            |.::..|:..|..|.:.||::||.|.....::...|.:........:.|.::..:..:||:.|.|
Human   382 MQQVSQLIRSTPHRVLHNYLVWRVVVVLSEHLSPPFREALHELAQEMEGSDKPQELARVCLGQAN 446

  Fly   706 TNMGMAVGSMFVSRYFDNNSKRDTLRMTHDLQQAFRDILKTTDWLDDTTKQLAEEKVNAMSLKIG 770
            .:.|||:|::||..:|...||....::..|::......|:..||:|..|:..|..|:..|.:.:|
Human   447 RHFGMALGALFVHEHFSAASKAKVQQLVEDIKYILGQRLEELDWMDAETRAAARAKLQYMMVMVG 511

  Fly   771 YPDFILNPSELNSKYAGIEIYPEKYFENTLNVLLHTAKTEQAKLHERVNKTNWQTAPAIVNAYYS 835
            ||||:|.|..::.:|. .|::.:.||:|.||.:..:.:....|:.:.|:|:.|...|..:||||.
Human   512 YPDFLLKPDAVDKEYE-FEVHEKTYFKNILNSIRFSIQLSVKKIRQEVDKSTWLLPPQALNAYYL 575

  Fly   836 RNKNQIMFPAGILQPPFYHRHFPKSLNFGGIGVVIGHELTHGFDDKGRLFDRNGNIHKWWTDSSI 900
            .||||::||||||||..|...||:|||:||||.:||||||||:||.|..:||:||:..|||::|.
Human   576 PNKNQMVFPAGILQPTLYDPDFPQSLNYGGIGTIIGHELTHGYDDWGGQYDRSGNLLHWWTEASY 640

  Fly   901 RGFDERARCIIAQYSNYTVEEVGIVLNGESTQGENIADNGGLRQAFHAYQRWLKEHPSEVSDEIL 965
            ..|..:|.||:..|.|:||....:  ||:.|.||||||.|||:.|:||||:|::||..|   ..|
Human   641 SRFLRKAECIVRLYDNFTVYNQRV--NGKHTLGENIADMGGLKLAYHAYQKWVREHGPE---HPL 700

  Fly   966 PGLNMTGPQLFFLNFGQVWCGAMRPEAIRNKLNTAIHSPGRFRVIGTLSNSVDFAREFNCPLGSP 1030
            |.|..|..||||:.|.|.||...|.::|..::.|..|:|..:||:|::|...:|.|.|:||..||
Human   701 PRLKYTHDQLFFIAFAQNWCIKRRSQSIYLQVLTDKHAPEHYRVLGSVSQFEEFGRAFHCPKDSP 765

  Fly  1031 MNPQKKCSVW 1040
            |||..|||||
Human   766 MNPAHKCSVW 775

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nep4	NP_650904.3	M13	274..1038	CDD:189000	245/775 (32%)
ECEL1	NP_004817.2	M13	120..773	CDD:341056	245/775 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150981
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG61902
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100162
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.760