Protein Alignment Nep4 and Ece1

DIOPT Version :9

• Sequence 1: NP_650904.3
• Gene: Nep4 / 42449
• FlyBaseID: FBgn0038818
• Length: 1040
• Species: Drosophila melanogaster
• Sequence 2: XP_006239337.1
• Gene: Ece1 / 94204
• RGDID: 620293
• Length: 769
• Species: Rattus norvegicus
• Alignment Length: 899
• Identity: 303/899 - (33%)
• Similarity: 448/899 - (49%)
• Gaps: 161/899 - (17%)

  Fly   172 RTSFLPLGIPRECLGSGIELDIKPIDEEAYQRQKKRYQDIAPYWLE--------KIRIRERREAE 228
            ||.:.||......||.           .:|:|.....:|:.....|        ::..|..|..:
  Rat     2 RTVWPPLAAALAALGM-----------SSYKRATLDEEDLVDSLSEGDVYPNGLQVNFRSPRSGQ 55

  Fly   229 R-HAEEASAE----------ISEATAALQSFWNEEGTR-EGIRMTQA-----KTMKRYMDNKVDP 276
            | .|...|.|          .:...|.|.:...:..|| ..:.:|:|     .::...||..|||
  Rat    56 RCWAARTSVEKRLVVLVTLLAAGLVACLAALGIQYRTRTPPVCLTEACVSVTSSILNSMDPTVDP 120

  Fly   277 CVDFYKYACGNWERLHPIPKDKAGFDTFEMLRESLDLVLRNLLEKNTPVHSAAELRKSPVRNTLF 341
            |.||:.||||.|.:.:|:|...:.:.||..|.|....::::|||.:|.  ||:|
  Rat   121 CQDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLENSTA--SASE----------- 172

  Fly   342 KLNEQGEGEGEADQAAELTAERLRRHIVSKRQLLNRVLVRYKRYTNGTKRKRLIETPRERTKEEE 406
                                                                             
  Rat   173 ----------------------------------------------------------------- 172

  Fly   407 AAPPVVLPKDKTKDKSDNEEQLHVPTDFLKPHQDAQLKAKNLYRSCVNSAVLAKRGLEPLHTLIR 471
                                              |:.||:..||:|:|...:.:...:||..||.
  Rat   173 ----------------------------------AEKKAQVYYRACMNETRIEELRAKPLMELIE 203

  Fly   472 ELGGWPVLESQWSESNFNWQVLAATLRRYNNDILIVQWVGADIKNSEENIVQFDQTGLGLPTREY 536
            :||||.: ...|::.||. ..|......|........:|.||.|||..|::|.||:|||||:|:|
  Rat   204 KLGGWNI-TGPWAKDNFQ-DTLQVVTAHYRTSPFFSVYVSADSKNSNSNVIQVDQSGLGLPSRDY 266

  Fly   537 FL-QPSNAKYLQAYQRYMAEVMHKMGASKADAQR-VASELVAFETQLAGITAPAEQRLNVTKLYK 599
            :| :..|.|.|..|..||.::...:|....|:.| ...:::.|||.||.||.|.|:|.:...:|.
  Rat   267 YLNKTENEKVLTGYLNYMVQLGKLLGGGDEDSIRPQMQQILDFETALANITIPQEKRRDEELIYH 331

  Fly   600 RMTLDQLQAVVPEIKWRAYLQSL-QDREVLGTEEVVIYAVEYMSKLVTLLDETDPRTVSNYMMWR 663
            ::|..:||.:.|.|.|..:|.:: ...|:..:|.:|:|..||:.::.||::.||...::|||||.
  Rat   332 KVTAAELQTLAPAINWLPFLNAIFYPVEINESEPIVVYDKEYLRQVSTLINSTDKCLLNNYMMWN 396

  Fly   664 FVRHRINNVDDRFDDIKQSFYHALFGREES--PQRWKVCIAQVNTNMGMAVGSMFVSRYFDNNSK 726
            .||...:.:|.||.|..:.|...::|.:::  | |||.|::....|:|.|:|.|||...|..:||
  Rat   397 LVRKTSSFLDQRFQDADEKFMEVMYGTKKTCLP-RWKFCVSDTENNLGFALGPMFVKATFAEDSK 460

  Fly   727 RDTLRMTHDLQQAFRDILKTTDWLDDTTKQLAEEKVNAMSLKIGYPDFILNPSELNSKYAGIEIY 791
            .....:..::::||.:.|.|..|:|:.|::.|:||.:|:...||||:||::|.||:..:......
  Rat   461 NIASEIILEIKKAFEESLSTLKWMDEDTRRSAKEKADAIYNMIGYPNFIMDPKELDKVFNDYTAV 525

  Fly   792 PEKYFENTLNVLLHTAKTEQAKLHERVNKTNWQTAPAIVNAYYSRNKNQIMFPAGILQPPFYHRH 856
            |:.||||.:.....:.:....:|.:..|:..|...|.:||||||..||:|:|||||||.|||.|.
  Rat   526 PDLYFENAMRFFNFSWRVTADQLRKAPNRDQWSMTPPMVNAYYSPTKNEIVFPAGILQAPFYTRS 590

  Fly   857 FPKSLNFGGIGVVIGHELTHGFDDKGRLFDRNGNIHKWWTDSSIRGFDERARCIIAQYSNYTVEE 921
            .|.:|||||||||:||||||.|||:||.:|::||:..||.:||:..|.::..|::.||:||:|.
  Rat   591 SPNALNFGGIGVVVGHELTHAFDDQGREYDKDGNLRPWWKNSSVEAFKQQTECMVQQYNNYSVN- 654

  Fly   922 VGIVLNGESTQGENIADNGGLRQAFHAYQRWLKEHPSEVSDEILPGLNMTGPQLFFLNFGQVWCG 986
             |..:||..|.||||||||||:.|:.|||.|:|::.:|   :|||.|.:|..|||||.|.||||.
  Rat   655 -GEPVNGRHTLGENIADNGGLKAAYRAYQNWVKKNGAE---QILPTLGLTSNQLFFLGFAQVWCS 715

  Fly   987 AMRPEAIRNKLNTAIHSPGRFRVIGTLSNSVDFAREFNCPLGSPMNPQKKCSVW 1040
            ...||:....|.|..|||.||||||:||||.:|:..|.|||||||||:.||.||
  Rat   716 VRTPESSHEGLITDPHSPSRFRVIGSLSNSKEFSEHFRCPLGSPMNPRHKCEVW 769

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nep4	NP_650904.3	M13	274..1038	CDD:189000	276/768 (36%)
Ece1	XP_006239337.1	PepO	105..769	CDD:226118	279/783 (36%)
		M13	118..767	CDD:189000	276/768 (36%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166344485
Domainoid	1	1.000	47	1.000	Domainoid score	I11668
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG61902
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100162
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.760