DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nep4 and MMEL1

DIOPT Version :9

Sequence 1:	NP_650904.3	Gene:	Nep4 / 42449	FlyBaseID:	FBgn0038818	Length:	1040	Species:	Drosophila melanogaster
Sequence 2:	NP_258428.2	Gene:	MMEL1 / 79258	HGNCID:	14668	Length:	779	Species:	Homo sapiens

Alignment Length:	850	Identity:	290/850 - (34%)
Similarity:	446/850 - (52%)	Gaps:	158/850 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   215 WLEKIRIRERREAERHAEEASAEISEATAALQSFWNEEGTREGIRMTQAKTMKRYMDNKVDPCVD 279
            :|::.|...:|: .|...||. |:||..           |..|..:..|:.::. ||...:||.|
Human    64 FLQEERTFVKRK-PRGIPEAQ-EVSEVC-----------TTPGCVIAAARILQN-MDPTTEPCDD 114

  Fly   280 FYKYACGNWERLHPIPKDKAGFDTFEMLRESLDLVLRNLLEKNTPVHSAAELRKSPVRNTLFKLN 344
            ||::|||.|.|.|.||:..:.:..|::||:.|:::|:.:||.:|
Human   115 FYQFACGGWLRRHVIPETNSRYSIFDVLRDELEVILKAVLENST--------------------- 158

  Fly   345 EQGEGEGEADQAAELTAERLRRHIVSKRQLLNRVLVRYKRYTNGTKRKRLIETPRERTKEEEAAP 409

Human   159 ----------------------------------------------------------------- 158

  Fly   410 PVVLPKDKTKDKSDNEEQLHVPTDFLKPHQDAQLKAKNLYRSCVNSAVLAKRGLEPLHTLIRELG 474
                    .||:...|                  ||:.|||||:|.:|:.|||.:||..::..:|
Human   159 --------AKDRPAVE------------------KARTLYRSCMNQSVIEKRGSQPLLDILEVVG 197

  Fly   475 GWPVLESQWSES-NFNWQV---LAATLRRYNNDILIVQWVGADIKNSEENIVQFDQTGLGLPTRE 535
            ||||...:|:|: ...|::   ||....::|..:||..::..|.:||..:|:..||..||:|:||
Human   198 GWPVAMDRWNETVGLEWELERQLALMNSQFNRRVLIDLFIWNDDQNSSRHIIYIDQPTLGMPSRE 262

  Fly   536 YFLQ-PSNAKYLQAYQRYMAEVMHKMGASKADA---------QRVASELVAFETQLAGITAPAEQ 590
            |:.. .||.|..:||.::|..|...:   :.||         |....:::..|||||..|.|.|:
Human   263 YYFNGGSNRKVREAYLQFMVSVATLL---REDANLPRDSCLVQEDMVQVLELETQLAKATVPQEE 324

  Fly   591 RLNVTKLYKRMTLDQLQAV--VPEIKWRAYLQSLQDR---EVLGTEEVVIYAVEYMSKLVTLLDE 650
            |.:|..||.||.|::||:.  :....|..::|::...   ::|..||||:|.:.|:..|..::|.
Human   325 RHDVIALYHRMGLEELQSQFGLKGFNWTLFIQTVLSSVKIKLLPDEEVVVYGIPYLQNLENIIDT 389

  Fly   651 TDPRTVSNYMMWRFVRHRINNVDDRFDDIKQSFYHALFGREESPQRWKVCIAQVNTNMGMAVGSM 715
            ...||:.||::||.|..||.::..||.|.:.::..||||......||:.|:..||:||..||||:
Human   390 YSARTIQNYLVWRLVLDRIGSLSQRFKDTRVNYRKALFGTMVEEVRWRECVGYVNSNMENAVGSL 454

  Fly   716 FVSRYFDNNSKRDTLRMTHDLQQAFRDILKTTDWLDDTTKQLAEEKVNAMSLKIGYPDFILNP-- 778
            :|...|..:||.....:...::..|.:.|....|:|:.:|:.|:||..::..:||:||:||..
Human   455 YVREAFPGDSKSMVRELIDKVRTVFVETLDELGWMDEESKKKAQEKAMSIREQIGHPDYILEEMN 519

  Fly   779 SELNSKYAGIEIYPEKYFENTLNVLLHTAKTEQAKLHERVNKTNWQTAPAIVNAYYSRNKNQIMF 843
            ..|:.:|:.:....:.||||:|..|...|:....||.|:|:...|....|:|||:||.|:|||:|
Human   520 RRLDEEYSNLNFSEDLYFENSLQNLKVGAQRSLRKLREKVDPNLWIIGAAVVNAFYSPNRNQIVF 584

  Fly   844 PAGILQPPFYHRHFPKSLNFGGIGVVIGHELTHGFDDKGRLFDRNGNIHKWWTDSSIRGFDERAR 908
            |||||||||:.:..|::|||||||:|||||:||||||.||.||:|||:..||::.|.:.|.|::.
Human   585 PAGILQPPFFSKEQPQALNFGGIGMVIGHEITHGFDDNGRNFDKNGNMMDWWSNFSTQHFREQSE 649

  Fly   909 CIIAQYSNYT---VEEVGIVLNGESTQGENIADNGGLRQAFHAYQRWLKEHPSEVSDEILPGLNM 970
            |:|.||.||:   .:|..:  ||.:|.|||||||||:|||:.||.:|:.|..   .|:.||||::
Human   650 CMIYQYGNYSWDLADEQNV--NGFNTLGENIADNGGVRQAYKAYLKWMAEGG---KDQQLPGLDL 709

  Fly   971 TGPQLFFLNFGQVWCGAMRPEAIRNKLNTAIHSPGRFRVIGTLSNSVDFAREFNCPLGSPMNPQK 1035
            |..||||:|:.|||||:.|||.....:.|.:|||.::||:|:|.|...||..|:|..|:||:|::
Human   710 THEQLFFINYAQVWCGSYRPEFAIQSIKTDVHSPLKYRVLGSLQNLAAFADTFHCARGTPMHPKE 774

  Fly  1036 KCSVW 1040
            :|.||
Human   775 RCRVW 779

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nep4	NP_650904.3	M13	274..1038	CDD:189000	273/787 (35%)
MMEL1	NP_258428.2	PepO	102..779	CDD:226118	276/797 (35%)
MMEL1	NP_258428.2	M13	111..777	CDD:189000	273/785 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150991
Domainoid	1	1.000	264	1.000	Domainoid score	I1924
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H22778
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG61902
OrthoDB	1	1.010	-	-		D157132at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100162
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.720