Protein Alignment Nep4 and Ecel1

DIOPT Version :10

• Sequence 1: NP_650904.3
• Gene: Nep4 / 42449
• FlyBaseID: FBgn0038818
• Length: 1040
• Species: Drosophila melanogaster
• Sequence 2: XP_063123735.1
• Gene: Ecel1 / 60417
• RGDID: 61806
• Length: 792
• Species: Rattus norvegicus
• Alignment Length: 753
• Identity: 232/753 - (30%)
• Similarity: 360/753 - (47%)
• Gaps: 126/753 - (16%)

  Fly   263 AKTMKRYMDNKVDPCVDFYKYACGNWERLHPIPKDKAGFDTFEMLRESLDLVLRNLLEKNTPVHS 327
            |:.:...:|..:|||.|||.:|||.|.|.|.||.||..:
  Rat   110 ARFLSANLDASIDPCQDFYSFACGGWLRRHAIPDDKLTY-------------------------- 148

  Fly   328 AAELRKSPVRNTLFKLNEQGEGEGEADQAAELTAERLRRHIVSKRQLLNRVLVRYKRYTNGTKRK 392
                      .|:..:.||.|             |||||.:.              |.|.|
  Rat   149 ----------GTIAAIGEQNE-------------ERLRRLLA--------------RPTGG---- 172

  Fly   393 RLIETPRERTKEEEAAPPVVLPKDKTKDKSDNEEQLHVPTDFLKPHQDAQLKAKNLYRSCVNSAV 457
                                                        |...||.|.:..:|||::...
  Rat   173 --------------------------------------------PGGAAQRKVRAFFRSCLDMRE 193

  Fly   458 LAKRGLEPLHTLIRELGGWPVLESQWSESNFNW---QVLAATLRRYNNDILIVQWVGADIKNSEE 519
            :.:.|..|:..:|.:.|||.:..:........|   ::|......|:...|....|..|.:||..
  Rat   194 IERLGPRPMLEVIEDCGGWDLGGAADRPGAARWDLNRLLYKAQGVYSAAALFSLTVSLDDRNSSR 258

  Fly   520 NIVQFDQTGLGLPTREYFL--QPSNAKYLQAYQRYMAEVMHKMGASKADAQRVASELVAFETQLA 582
            .:::.||.||.||.|..:|  ...:.|.|.||:.:|..::..:||...:.:  |.|::..|.:||
  Rat   259 YVIRIDQDGLTLPERTLYLAQDEESEKVLAAYKVFMERLLRLLGADAVEQK--AQEILQLEQRLA 321

  Fly   583 GITAPA--EQRLNVTKLYKRMTLDQLQAVVPEIKWRAYLQSLQDREVLGTEEVVIYAVEYMSKLV 645
            .|:...  :.|.:|:.:|.::||.|||.:.|.::|:..|..:...:....||||:.|.:||.::.
  Rat   322 NISVSEYDDLRRDVSSVYNKVTLGQLQKITPHLQWKWLLDQIFQEDFSEEEEVVLLATDYMQQVS 386

  Fly   646 TLLDETDPRTVSNYMMWRFVRHRINNVDDRFDDIKQSFYHALFGREESPQRWKVCIAQVNTNMGM 710
            .|:..|..|.:.||::||.|.....::...|.:........:.|.::..:..:||:.|.|.:.||
  Rat   387 QLIRSTPRRILHNYLVWRVVVVLSEHLSPPFREALHELAKEMEGNDKPQELARVCLGQANRHFGM 451

  Fly   711 AVGSMFVSRYFDNNSKRDTLRMTHDLQQAFRDILKTTDWLDDTTKQLAEEKVNAMSLKIGYPDFI 775
            |:|::||..:|...||....::..|::......|:..||:|..||..|..|:..|.:.:|||||:
  Rat   452 ALGALFVHEHFSAASKAKVQQLVEDIKYILGQRLEELDWMDAQTKAAARAKLQYMMVMVGYPDFL 516

  Fly   776 LNPSELNSKYAGIEIYPEKYFENTLNVLLHTAKTEQAKLHERVNKTNWQTAPAIVNAYYSRNKNQ 840
            |.|..::.:|. .|::.:.||:|.||.:..:.:....|:.:.|:|:.|...|..:||||..||||
  Rat   517 LKPEAVDKEYE-FEVHEKTYFKNILNSIRFSIQLSVKKIRQEVDKSTWLLPPQALNAYYLPNKNQ 580

  Fly   841 IMFPAGILQPPFYHRHFPKSLNFGGIGVVIGHELTHGFDDKGRLFDRNGNIHKWWTDSSIRGFDE 905
            ::||||||||..|...||:|||:||||.:||||||||:||.|..:||:||:..|||::|...|..
  Rat   581 MVFPAGILQPTLYDPDFPQSLNYGGIGTIIGHELTHGYDDWGGQYDRSGNLLHWWTEASYSRFLH 645

  Fly   906 RARCIIAQYSNYTVEEVGIVLNGESTQGENIADNGGLRQAFHAYQRWLKEHPSEVSDEILPGLNM 970
            :|.||:..|.|:||....:  ||:.|.||||||.|||:.|::|||:|::||..|   ..|..|..
  Rat   646 KAECIVRLYDNFTVYNQRV--NGKHTLGENIADMGGLKLAYYAYQKWVREHGPE---HPLHRLKY 705

  Fly   971 TGPQLFFLNFGQVWCGAMRPEAIRNKLNTAIHSPGRFR 1008
            |..||||:.|.|.||...|.::|..::.|..|:|..:|
  Rat   706 THNQLFFIAFAQNWCIKRRSQSIYLQVLTDKHAPEHYR 743

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nep4	NP_650904.3	M13	274..1038	CDD:341056	230/742 (31%)
Ecel1	XP_063123735.1	None