DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nep4 and mmel1

DIOPT Version :9

Sequence 1:	NP_650904.3	Gene:	Nep4 / 42449	FlyBaseID:	FBgn0038818	Length:	1040	Species:	Drosophila melanogaster
Sequence 2:	XP_017213856.1	Gene:	mmel1 / 560703	ZFINID:	ZDB-GENE-101112-2	Length:	765	Species:	Danio rerio

Alignment Length:	833	Identity:	282/833 - (33%)
Similarity:	423/833 - (50%)	Gaps:	149/833 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   242 TAALQSFWNEEGTREGIR---------------MTQAKTMKRYMDNKVDPCVDFYKYACGNWERL 291
            |:||:..:|...:.:|::               :|.|..:.:.||..||||.:||:||||.|...
Zfish    48 TSALRERFNINDSSKGLKYRSDADSNVCTTPQCVTAAARLLQNMDPSVDPCQNFYQYACGGWIER 112

  Fly   292 HPIPKDKAGFDTFEMLRESLDLVLRNLLEKNTPVHSAAELRKSPVRNTLFKLNEQGEGEGEADQA 356
            |.||:..:....|.:||:.|::||:.:||
Zfish   113 HVIPETSSLHSVFNILRDELEIVLKGVLE------------------------------------ 141

  Fly   357 AELTAERLRRHIVSKRQLLNRVLVRYKRYTNGTKRKRLIETPRERTKEEEAAPPVVLPKDKTKDK 421
                                                                         .::|
Zfish   142 -------------------------------------------------------------MENK 145

  Fly   422 SDNEEQLHVPTDFLKPHQDAQLKAKNLYRSCVNSAVLAKRGLEPLHTLIRELGGWPVLESQWS-E 485
            .|.|               |..|||.||.||:|..::.:|..:||..||..:|.|||....|: .
Zfish   146 DDRE---------------AFKKAKTLYSSCMNEILIEQRDSQPLLRLIDSIGDWPVASEVWNGT 195

  Fly   486 SNFNWQV---LAATLRRYNNDILIVQWVGADIKNSEENIVQFDQTGLGLPTREYFLQPSNAKYL- 546
            |...|.:   ||....|||...::..:|..|.::|...|:..||..||:|:|:|:|...|.|.:
Zfish   196 SEQTWSLEDTLAVLNGRYNKKAVLEMFVWPDDRDSSRYIIHVDQPALGMPSRDYYLSDGNYKKVR 260

  Fly   547 QAYQRY---MAEVMHKMGASKADAQRV---ASELVAFETQLAGITAPAEQRLNVTKLYKRMTLDQ 605
            :||..:   ||.:..:......|.:||   .|:::..||.:|..|:|||:|.::|.||.:|||.:
Zfish   261 EAYLEFMVSMARIAREDRNLTQDEERVLEDMSQVLELETDIANATSPAEERNDITVLYNKMTLRE 325

  Fly   606 LQAV--VPEIKWRAYLQSLQDR---EVLGTEEVVIYAVEYMSKLVTLLDETDPRTVSNYMMWRFV 665
            .|..  :....|..|:|.:...   .|...|.:|||...|:.||..:|.:...||:.||::|..:
Zfish   326 AQQTFNLNGFNWTRYIQGIMSSVSISVQSDEPIVIYCSPYLEKLSEVLSKHSHRTLQNYLVWMLI 390

  Fly   666 RHRINNVDDRFDDIKQSFYHALFGREESPQRWKVCIAQVNTNMGMAVGSMFVSRYFDNNSKRDTL 730
            ..|::::..||.|::..:..||.|......||:.|:..|..||..|||:::|...|..||||...
Zfish   391 MDRVSSMSRRFKDVRAHYRKALHGTTVEEARWRDCVRYVQGNMENAVGALYVRETFSGNSKRMVG 455

  Fly   731 RMTHDLQQAFRDILKTTDWLDDTTKQLAEEKVNAMSLKIGYPDFILNP--SELNSKYAGIEIYPE 793
            .:...:|:|:.:.|:...|:|:.:|..|.||..|:|.:|||||.||..  .:|:.:||.:....|
Zfish   456 ELIKKIQEAYVETLEELSWMDEQSKVKAREKAMAISEQIGYPDHILEEENKKLDQEYAHLNFSEE 520

  Fly   794 KYFENTLNVLLHTAKTEQAKLHERVNKTNWQTAPAIVNAYYSRNKNQIMFPAGILQPPFYHRHFP 858
            .||||.|..|..:|:....||.|.|:...|....|:|||:||.|:|||:||||||||||:.....
Zfish   521 NYFENILENLAASAQKGHKKLREPVDPDMWIIGAAVVNAFYSHNRNQIVFPAGILQPPFFSEKQL 585

  Fly   859 KSLNFGGIGVVIGHELTHGFDDKGRLFDRNGNIHKWWTDSSIRGFDERARCIIAQYSNYTVEEV- 922
            ::|||||||:|||||:||||||.||.||::||::.||::.|...|:::::|::.||..::.:..
Zfish   586 QALNFGGIGMVIGHEITHGFDDHGRNFDKDGNMYNWWSNYSAERFEDQSKCMVEQYGRFSWKLAG 650

  Fly   923 GIVLNGESTQGENIADNGGLRQAFHAYQRWLKEHPSEVSDEILPGLNMTGPQLFFLNFGQVWCGA 987
            |..::|.:|.|||||||||:|||:.||.:|::.   |..:..||||:|...|||||||.||||||
Zfish   651 GQNVSGITTLGENIADNGGVRQAYKAYVKWVER---EGEEPRLPGLDMNHKQLFFLNFAQVWCGA 712

  Fly   988 MRPEAIRNKLNTAIHSPGRFRVIGTLSNSVDFAREFNCPLGSPMNPQKKCSVW 1040
            .|||.....:.|..|||..:||:|:|.|...|:..|:|..|:||||::||.||
Zfish   713 CRPEYAIQTIKTDPHSPLEYRVLGSLQNFEAFSEAFHCARGAPMNPEEKCRVW 765

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nep4	NP_650904.3	M13	274..1038	CDD:189000	270/782 (35%)
mmel1	XP_017213856.1	PepO	88..765	CDD:226118	273/791 (35%)
mmel1	XP_017213856.1	M13	95..763	CDD:189000	270/782 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170585596
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H22778
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG61902
OrthoDB	1	1.010	-	-		D157132at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100162
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.860