Protein Alignment Nep4 and PHEX

DIOPT Version :9

• Sequence 1: NP_650904.3
• Gene: Nep4 / 42449
• FlyBaseID: FBgn0038818
• Length: 1040
• Species: Drosophila melanogaster
• Sequence 2: NP_000435.3
• Gene: PHEX / 5251
• HGNCID: 8918
• Length: 749
• Species: Homo sapiens
• Alignment Length: 787
• Identity: 257/787 - (32%)
• Similarity: 387/787 - (49%)
• Gaps: 131/787 - (16%)

  Fly   274 VDPCVDFYKYACGNWERLHPIPKDKAGFDTFEMLRESLDLVLRNLLEKNTPVHSAAELRKSPVRN 338
            ||||.:|:::||..|...:|||:|...:..:..||.::||.|:.||||:
Human    74 VDPCDNFFRFACDGWISNNPIPEDMPSYGVYPWLRHNVDLKLKELLEKS---------------- 122

  Fly   339 TLFKLNEQGEGEGEADQAAELTAERLRRHIVSKRQLLNRVLVRYKRYTNGTKRKRLIETPRERTK 403
                                          :|:|:
Human   123 ------------------------------ISRRR------------------------------ 127

  Fly   404 EEEAAPPVVLPKDKTKDKSDNEEQLHVPTDFLKPHQDAQLKAKNLYRSCVNSAVLAKRGLEP-LH 467
                               |.|               |..|||.||.||:|...:.|...:| ||
Human   128 -------------------DTE---------------AIQKAKILYSSCMNEKAIEKADAKPLLH 158

  Fly   468 TLIRELGGWPVLESQ------WSESNFNWQVLAATLR-RYNNDILIVQWVGADIKNSEENIVQFD 525
            .|......||||||.      |||..|:.....||.| :|:|.:.|..:|..|.|.|.|:|::.|
Human   159 ILRHSPFRWPVLESNIGPEGVWSERKFSLLQTLATFRGQYSNSVFIRLYVSPDDKASNEHILKLD 223

  Fly   526 QTGLGLPTREYFLQPS-NAK-YLQAYQRYMAEVMHKMGASKADAQRVASELVAFETQLAGITAPA 588
            |..|.|..||.:|..| .|| |..|..::|.:....:||:.:.|:.....::..|.::|.|..|.
Human   224 QATLSLAVREDYLDNSTEAKSYRDALYKFMVDTAVLLGANSSRAEHDMKSVLRLEIKIAEIMIPH 288

  Fly   589 EQRLNVTKLYKRMTLDQLQAVVPEIKWRAYLQSLQD-------REVLGTEEVVIYAVEYMSKLVT 646
            |.|.: ..:|.:|.:.:|.|::|:..|..|::.:.|       :::..:|.||:...:|...|..
Human   289 ENRTS-EAMYNKMNISELSAMIPQFDWLGYIKKVIDTRLYPHLKDISPSENVVVRVPQYFKDLFR 352

  Fly   647 LLDETDPRTVSNYMMWRFVRHRINNVDDRFDDIKQSFYHALFGREESPQRWKVCIAQVNTNMGMA 711
            :|.....:|::||::||.|..||.|:..||......|...:.|......:|..|:..:.:.:...
Human   353 ILGSERKKTIANYLVWRMVYSRIPNLSRRFQYRWLEFSRVIQGTTTLLPQWDKCVNFIESALPYV 417

  Fly   712 VGSMFVSRYFDNNSKRDTLRMTHDLQQAFRDIL-KTTDWLDDTTKQLAEEKVNAMSLKIGYPDFI 775
            ||.|||..||..:.|.....:...::.||.|:| |..:|:|..||:.|:||..|:..|:|||:||
Human   418 VGKMFVDVYFQEDKKEMMEELVEGVRWAFIDMLEKENEWMDAGTKRKAKEKARAVLAKVGYPEFI 482

  Fly   776 LNPSELNSKYAGIEIYPEKYFENTLNVLLHTAKTEQAKLHERVNKTNWQTAPAIVNAYYSRNKNQ 840
            :|.:.:|.....|:.....||.|.|....:.|:::...|.:.|.||.|.|.|..|||:||.:.||
Human   483 MNDTHVNEDLKAIKFSEADYFGNVLQTRKYLAQSDFFWLRKAVPKTEWFTNPTTVNAFYSASTNQ 547

  Fly   841 IMFPAGILQPPFY-HRHFPKSLNFGGIGVVIGHELTHGFDDKGRLFDRNGNIHKWWTDSSIRGFD 904
            |.||||.||.||: ...:|:||::|.|||::|||.|||||:.||.:|:|||:..||:..|...|.
Human   548 IRFPAGELQKPFFWGTEYPRSLSYGAIGVIVGHEFTHGFDNNGRKYDKNGNLDPWWSTESEEKFK 612

  Fly   905 ERARCIIAQYSNYTVEEVGIVLNGESTQGENIADNGGLRQAFHAYQRWLKEHPSEVSDEILPGLN 969
            |:.:|:|.|||||..::.|:.:.|:.|.|||||||||||:||.||::|:.:....:.:.:|||:.
Human   613 EKTKCMINQYSNYYWKKAGLNVKGKRTLGENIADNGGLREAFRAYRKWINDRRQGLEEPLLPGIT 677

  Fly   970 MTGPQLFFLNFGQVWCGAMRPEAIRNKLNTAIHSPGRFRVIGTLSNSVDFAREFNCPLGSPMN-P 1033
            .|..|||||::..|.|.:.||||.|.::....|||.:|||.|.:||..:|.:.||||..|.|| .
Human   678 FTNNQLFFLSYAHVRCNSYRPEAAREQVQIGAHSPPQFRVNGAISNFEEFQKAFNCPPNSTMNRG 742

  Fly  1034 QKKCSVW 1040
            ...|.:|
Human   743 MDSCRLW 749

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nep4	NP_650904.3	M13	274..1038	CDD:189000	255/783 (33%)
PHEX	NP_000435.3	M13	74..747	CDD:189000	255/783 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG61902
OrthoDB	1	1.010	-	-		D157132at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.930