DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nep4 and Nepl21

DIOPT Version :9

Sequence 1:	NP_650904.3	Gene:	Nep4 / 42449	FlyBaseID:	FBgn0038818	Length:	1040	Species:	Drosophila melanogaster
Sequence 2:	NP_651646.2	Gene:	Nepl21 / 43413	FlyBaseID:	FBgn0027578	Length:	707	Species:	Drosophila melanogaster

Alignment Length:	816	Identity:	229/816 - (28%)
Similarity:	351/816 - (43%)	Gaps:	190/816 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   260 MTQAKT--MKRYMDNKVDPCVDFYKYACGNWERLHPIPKDKAGFDTFEMLRESLDLVLRNLLEKN 322
            :.||||  ::.:||.|.|||.|||.::|||::|::.              ..|:.:|...:.|
  Fly    47 LRQAKTAEIESFMDQKADPCNDFYAFSCGNYKRINS--------------ALSMQVVTTGVFE-- 95

  Fly   323 TPVHSAAELRKSPVRNTLFKLNEQGEGEGEADQAAELTAERLRRHIVSKRQLLNRVLVRYKRYTN 387
                            ||                                             |.
  Fly    96 ----------------TL---------------------------------------------TK 99

  Fly   388 GTKRK--RLIETPRERTKEEEAAPPVVLPKDKTKDKSDNEEQLHVPTDFLKPHQDAQLKAKNLYR 450
            |..||  :::.||.                    |..|..|               .:|.|:.|.
  Fly   100 GLNRKILKMLNTPH--------------------DSHDTPE---------------DIKVKHFYE 129

  Fly   451 SCVNSAVLAKRGLEPLHTLIRELGGWPVLE-SQWSESNFNWQVLAATLR---RYNNDILIVQWVG 511
            ||:....|.....|.|..||.|.|..|:|| |.|.|.:|:|  |..|.|   ||....:....|.
  Fly   130 SCLQIKELNSTYSEKLKRLIAEFGTMPLLEGSSWQEDDFDW--LNTTARMAYRYGITPIFGIEVN 192

  Fly   512 ADIKNSEENIVQFDQTGLGLPTREYFLQPSNAKYLQAYQRYMAEVMHKMGASKAD-AQRVASELV 575
            .|:.::..|.:...|....|..|..::..:.|.|.|.|:..:..::.:....|.| |::.|.||:
  Fly   193 KDLASNTRNRIYLGQQDFPLEARSMYVDDATAVYRQKYRNNIQRILQRYLGVKMDLAKKTAKELI 257

  Fly   576 AFETQLAGITAPAEQRLNVTKLYKRMTLDQLQAVVPEIKWRAYLQSLQ-DREV---LG---TEEV 633
            .||..||.......:.|:|.:|.:.:|:|::|        |.|..:|. ||.:   :|   ::::
  Fly   258 DFEVDLAQGLVDESEGLDVGELTQLLTVDEIQ--------RRYSPTLDIDRLLFVSMGERISDQI 314

  Fly   634 VIYAVEYMSKLVTLLDETDPRTVSNYMMWRFVRHRINNVDDRFDDIKQSFYHALFGREESPQR-W 697
            ..|...|...||.::..|..|||:||:.:|.:...:....|                  ||:: .
  Fly   315 YEYNNRYQQNLVEVIKRTPKRTVANYIFFRLIWEFVETPSD------------------SPEKQM 361

  Fly   698 KVCIAQVNTNMGMAVGSMFVSRYFDNNSKRDTLRMTHDLQQAFRDILKTT---DWLDDTTKQLAE 759
            |.|:..........:.:||..||.:..|.|:...|...|:..|.:.|:::   :|::..|:.||.
  Fly   362 KACVDLTKKYFAKNLDNMFYRRYNNEKSSREIDNMWRQLKSTFNETLRSSPALNWIERPTRNLAM 426

  Fly   760 EKVNAMSLKI-GYPDFILNPSELNSKYAGIEIYPEKYFENTLNVLLHTAKTEQAKLH------ER 817
            .|:.||:|:: .|.|     .....::|.:.:..:.|.||.....|..||..:..||      |.
  Fly   427 AKLQAMTLEVNNYAD-----DNFTEEFAELNLQSDDYVENVRYTSLLGAKQMREMLHKPAKPFEA 486

  Fly   818 VNKTNWQTAPAIVNAYYSRNKNQIMFPAGILQPPFY--HRHFPKSLNFGGIGVVIGHELTHGFDD 880
            .::.::..|..::       :|.|..|..:|| |||  ...:|.::.||.:..:|||||.|||||
  Fly   487 GSQLSYTPANILI-------ENTIKVPVALLQ-PFYIWSDVYPNAIMFGTLASLIGHELIHGFDD 543

  Fly   881 KGRLFDRNGNIHKWWTDSSIRGFDERARCIIAQYSNYTVEEVGIVLNGESTQGENIADNGGLRQA 945
            .||.||..||...||.:.|...|.:|..|...||..|..:  ||.|...:.|.||||||||:|.|
  Fly   544 SGRKFDEKGNSKDWWDEKSSSNFLKRRDCFTKQYGRYVYD--GIQLKESTAQSENIADNGGMRLA 606

  Fly   946 FHAYQRW------LKEHPSEVSDEILPGLNMTGPQLFFLNFGQVWCGAMRPEAIRNKLNTAIHSP 1004
            :.||::|      |.....:::.|.||.|..|..||||::|.|.||....|.....:::|..|.|
  Fly   607 YTAYRKWYENQLTLPNGAQDMTKETLPNLRYTAKQLFFISFAQSWCNDAHPSVKALQVSTDQHMP 671

  Fly  1005 GRFRVIGTLSNSVDFAREFNCPLGSPMNPQKKCSVW 1040
            |||||||:|||..:|::|||||.||.|||.:||.::
  Fly   672 GRFRVIGSLSNFEEFSKEFNCPAGSAMNPSEKCILY 707

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nep4	NP_650904.3	M13	274..1038	CDD:189000	221/796 (28%)
Nepl21	NP_651646.2	PepO	57..707	CDD:226118	225/804 (28%)
Nepl21	NP_651646.2	M13	63..704	CDD:189000	220/795 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45454988
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.950