DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nep4 and Nepl20

DIOPT Version :9

Sequence 1:	NP_650904.3	Gene:	Nep4 / 42449	FlyBaseID:	FBgn0038818	Length:	1040	Species:	Drosophila melanogaster
Sequence 2:	NP_651645.1	Gene:	Nepl20 / 43412	FlyBaseID:	FBgn0039613	Length:	700	Species:	Drosophila melanogaster

Alignment Length:	824	Identity:	226/824 - (27%)
Similarity:	351/824 - (42%)	Gaps:	198/824 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   255 REGIRMTQAKTMKRYMDNKVDPCVDFYKYACGNWERLHPIPKDKAGFDTFEMLRESLDLVLRNLL 319
            :|.:|..:|..::.:|:.|||||.|||.::|||::|
  Fly    37 KELMRQAKAAEIESFMNQKVDPCKDFYAFSCGNYKR----------------------------- 72

  Fly   320 EKNTPVHSAAELRKSPVRNTLFKLNEQGEGEGEADQAAELTAERLRRHIVSKRQLLNRVLVR--Y 382
                 ::||..:                                             |||..  :
  Fly    73 -----INSALNM---------------------------------------------RVLTTGVF 87

  Fly   383 KRYTNGTKRK--RLIETPRERTKEEEAAPPVVLPKDKTKDKSDNEEQLHVPTDFLKPHQDAQLKA 445
            :..|.|..||  :::.||.                    |..|..|.:.|
  Fly    88 ETLTKGLNRKILKMLNTPH--------------------DSHDTPEDIQV--------------- 117

  Fly   446 KNLYRSCVNSAVLAKRGLEPLHTLIRELGGWPVLE-SQWSESNFNW-QVLAATLRRYNNDILIVQ 508
            |:.|.||:....|.....|.|..||.|.|..|:|| |.|.|.:|:| ...|....||....:|..
  Fly   118 KHFYESCLQIKELNSTYSEKLKRLIAEFGTMPLLEGSSWQEDDFDWLNTTARMAHRYGIMSIIGV 182

  Fly   509 WVGADIKNSEENIVQFDQTGLGLPTREYFLQPSNAKYLQAYQRYMAEVMHK-MGASKADAQRVAS 572
            .|..|..|:::||:..:|....|.||..::....|.|.|.||..:..::.| :|.....|::.|.
  Fly   183 GVATDFANNQKNIIYINQQEFPLKTRSMYMDNETAIYRQNYQNNIQLILEKYLGVKDELARKAAK 247

  Fly   573 ELVAFETQLAGITAPAEQRLNVTKLYKRMTLDQLQAVVPEIKWRAYLQSLQDREVLG-------T 630
            |:..||..||.......:.||:..|.:.:|:.:|:        ..|..:|...:::.       :
  Fly   248 EMFEFEVDLAHGLVDNNKHLNLRDLIELLTVAELR--------ERYAPTLDTDQLIFVSMGEKIS 304

  Fly   631 EEVVIYAVEYMSKLVTLLDETDPRTVSNY----MMWRFVRHRINNVDDRFDDIKQSFYHALFGRE 691
            ::|..|...|...||.:::.|...||:||    ::|.|::             |.|      |..
  Fly   305 DKVYEYNRRYQQNLVEVIERTPKSTVANYLFLRLIWEFIQ-------------KPS------GVA 350

  Fly   692 ESPQRWKVCIAQVNTNMGMAVGSMFVSRYFDNNSKRDTLRMTHDLQQAFRDILKTT---DWLDDT 753
            |.|.  :.|:....|.....:.:|...||.:..|.|:...|.|.|:..|::.|.::   ||::.:
  Fly   351 EKPT--EACVDFTKTYFAKNLDNMIYRRYKNEKSSREIDSMWHQLKSTFKETLLSSPALDWIEPS 413

  Fly   754 TKQLAEEKVNAMSLKIGYPDFILNPSELNSKYAGIEIYPEKYFENTLNVLLHTAKTEQAKLHERV 818
            |:.||..|:.||:|::.  :::  ......::|.:.:......||...|.:..||..:...|:
  Fly   414 TRSLAIAKLEAMTLEVN--NYV--KENFTEEFADLNLQNTDCVENLRQVQMLQAKQMRQLYHQ-- 472

  Fly   819 NKTNWQTAPA------IVNAYYSRN---KNQIMFPAGILQPPFY--HRHFPKSLNFGGIGVVIGH 872
                    ||      .:.:|...|   :|.|..|..:|| |||  ...:|.::.||.:..:|||
  Fly   473 --------PAKPLEAGELLSYTPSNILLENSIKVPVALLQ-PFYIWSDVYPNAVMFGTLAYLIGH 528

  Fly   873 ELTHGFDDKGRLFDRNGNIHKWWTDSSIRGFDERARCIIAQYSNYTVEEVGIVLNGESTQGENIA 937
            ||.|||||.||.||..||...||.:.|...|.:|..|...||..|..:  ||.|...:.|.||||
  Fly   529 ELIHGFDDSGRKFDEKGNSKDWWDEKSSSNFLKRRDCFTKQYGRYVYD--GIQLKESTAQSENIA 591

  Fly   938 DNGGLRQAFHAYQRW------LKEHPSEVSDEILPGLNMTGPQLFFLNFGQVWCGAMRPEAIRNK 996
            ||||:|.|:.||::|      |.....:::.|.||.|..|..||||::|.|.||..:.|:....:
  Fly   592 DNGGMRLAYTAYRKWYENQLTLPNGAQDMTKETLPNLRYTAKQLFFISFAQSWCNDVHPKVKALQ 656

  Fly   997 LNTAIHSPGRFRVIGTLSNSVDFAREFNCPLGSPMNPQKKCSVW 1040
            ::|..|.||:|||||||||..:|::||||..||.|||.:||.::
  Fly   657 VSTDDHMPGKFRVIGTLSNFEEFSKEFNCHAGSAMNPIEKCILY 700

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nep4	NP_650904.3	M13	274..1038	CDD:189000	220/801 (27%)
Nepl20	NP_651645.1	PepO	50..691	CDD:226118	218/800 (27%)
Nepl20	NP_651645.1	M13	56..697	CDD:189000	219/800 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45454989
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S6404
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.800