DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nep4 and Nepl19

DIOPT Version :9

Sequence 1:	NP_650904.3	Gene:	Nep4 / 42449	FlyBaseID:	FBgn0038818	Length:	1040	Species:	Drosophila melanogaster
Sequence 2:	NP_651644.1	Gene:	Nepl19 / 43411	FlyBaseID:	FBgn0039612	Length:	671	Species:	Drosophila melanogaster

Alignment Length:	810	Identity:	196/810 - (24%)
Similarity:	332/810 - (40%)	Gaps:	227/810 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   258 IRMTQAKTMKRYMDNKVDPCVDFYKYACGNWERLHPIPKDKAGFDTFEMLRESLDLVLRNLLEKN 322
            :|::::..|:.||....|.|.:||.|:||||.:::|      ..|.:.  ||:
  Fly    57 MRLSKSAEMRSYMQQDADACENFYDYSCGNWPQINP------ANDAYP--RET------------ 101

  Fly   323 TPVHSAAELRKSPVRNTLFKLNEQGEGEGEADQAAELTAERLRRHIVSKRQLLNRVLVRYKRYTN 387
                                                                 |.|.:..|.|::
  Fly   102 -----------------------------------------------------NFVQLLLKAYSH 113

  Fly   388 GTKRKRLIETPRERTKEEEAAPPVVLPKDKTKDKSDNEEQLHVPTDFLKPHQDAQLKAKNLYRSC 452
              |::||:|.|                             .:|.||     :.|.|:.|..|.||
  Fly   114 --KQQRLMEQP-----------------------------ANVETD-----EVAVLRLKEFYASC 142

  Fly   453 VNSAVLAKRGLEPLH-----TLIRELGGWPVLE---SQWSESNFNW-QVLAATLRRYNNDILIVQ 508
                :|.::..|.|:     .::.:.|..|||.   .:|....|:| ..:|...|:|..|||::.
  Fly   143 ----LLFRQVPEDLYRRQLQEIVADFGRMPVLSLPGQEWPAEEFDWLDTVARIKRQYGFDILLLF 203

  Fly   509 WVGADIKNSEENIVQFDQTGLGLPTREYFLQPSNAKYLQAYQRYMAE-----VMHKMGASKADAQ 568
            ...||                    |.|..||... ..:|.::.:||     :...:|.....|.
  Fly   204 QQSAD--------------------RIYVGQPKQI-LPEANRKAVAEDIANHLERHLGVDPKVAV 247

  Fly   569 RVASELVAFETQLAGITAPAEQRLNV-TKLYKRMTLDQLQAVVPEIKWRAYLQSLQDREVLGTEE 632
            ..|.|:..||.::|.|.  .::|:.| :|||.....|    .|...|...:::::.|||:|..|.
  Fly   248 TTAREITEFEQKIAAIM--VDRRVGVMSKLYTPSDAD----YVDVSKLTQFVETVLDRELLANES 306

  Fly   633 VVIYAVEYMSKLVTLLDETDPRTVSNYMMWRFVRHRINNVDDRFDDIKQSFYHALFGREESPQRW 697
            :..:..:|:.|:..|:.||.|..::||:               |:::.:.||:     |.:....
  Fly   307 LYQHVPDYLMKIDELVTETPPHVLANYV---------------FNELLKHFYY-----ERAESVV 351

  Fly   698 KVCIAQVNTNMGMAVGSMFVSRYFDNNSKRDTLRMTHDLQQAFRDILK--TTDWLDDTTKQLAEE 760
            :.|:::|....|..:..|...:|.|..:.:|...:...||::||.:|:  :.:||...|::...|
  Fly   352 EQCVSRVRDLFGELLDHMLFEQYEDEGTLKDIYVVWQQLQRSFRGVLQNSSANWLVPETREQLLE 416

  Fly   761 KVNAMSLKI-GYPDFILNPSELN--SKYAGIEIYPEKYFENTLNVLLHTA-----KTEQAKLHER 817
            ::|..||.| ||       :|:|  .:|..:.:.|..|..|...:|.|.:     ||:.:..::.
  Fly   417 QLNTTSLVINGY-------AEVNFTQRYEELHLKPRDYLHNLRTILNHQSLRVKVKTQTSVTYDP 474

  Fly   818 VNKTNWQTAPAIVNAYYSRNKNQIMFPAGILQPPF-YHRHFPKSLNFGGIGVVIGHELTHGFDDK 881
            |.|                   :::.|..:|||.| :.|::||::.:|.:|.::..:|.|..:|.
  Fly   475 VGK-------------------RVLLPVALLQPNFLWSRYYPKAVRYGSLGTLLAQQLAHSLEDA 520

  Fly   882 GRLFDRNGNIHKWWTDSSIRGFDERARCIIAQYSNYTVEEVGIVLNGESTQGENIADNGGLRQAF 946
            .:           |...|...:.:|..|...||....:.  |..|.....|.||||||..::.|:
  Fly   521 SK-----------WDAKSFAEYSKRKSCFKEQYGRLRLN--GHYLPESDLQAENIADNLAIQVAY 572

  Fly   947 HAYQRWLKE-HPSEVSDEILPGLNMTGPQLFFLNFGQVWCGAMRPEAIRNKLNTAIHSPGRFRVI 1010
            |||:|.|.| .||.:..|.||.||:...:||||:|.|:||.... |..|:|.:..:.:|...||:
  Fly   573 HAYRRLLAELDPSFLGSESLPQLNLGSRRLFFLSFAQLWCNDAN-EQFRDKQSLFLGTPNALRVL 636

  Fly  1011 GTLSNSVDFAREFNCPLGSPMNPQKKCSVW 1040
            |.|||...|.|:|||...|.|...:||.::
  Fly   637 GALSNFRAFGRDFNCGTASRMTSPQKCQLF 666

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nep4	NP_650904.3	M13	274..1038	CDD:189000	191/790 (24%)
Nepl19	NP_651644.1	PepO	67..657	CDD:226118	191/789 (24%)
Nepl19	NP_651644.1	M13	73..664	CDD:189000	191/790 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45454986
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.850