DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nep4 and Nepl17

DIOPT Version :9

Sequence 1:	NP_650904.3	Gene:	Nep4 / 42449	FlyBaseID:	FBgn0038818	Length:	1040	Species:	Drosophila melanogaster
Sequence 2:	NP_651641.1	Gene:	Nepl17 / 43408	FlyBaseID:	FBgn0039609	Length:	681	Species:	Drosophila melanogaster

Alignment Length:	856	Identity:	201/856 - (23%)
Similarity:	335/856 - (39%)	Gaps:	229/856 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   234 ASAEISEATAALQSFWNEEGT---------REGIRMTQAKTMKRYMDNKVDPCVDFYKYACGNWE 289
            |||.:...|.|:.|...:.|.         ::.:|:.::..|..:||..|.||.|||.|||||:
  Fly     6 ASACLIFVTLAVGSLAIQGGVFKELTTPLGQQIMRIAKSAEMCSFMDTSVSPCDDFYGYACGNY- 69

  Fly   290 RLHPIPKDKAGFDTFEMLRESLDLVLRNLLEKNTPVHSAAELRKSPVRNTLFKLNEQGEGEGEAD 354
                                             ..:::|...:.:.:|..:|
  Fly    70 ---------------------------------ATINAATSQKDTNIRQLMF------------- 88

  Fly   355 QAAELTAERLRRHIVSKRQLLNRVLVRYKRYTNGTKRKRLIETPRERTKEEEAAPPVVLPKDKTK 419
                  |..|||    .||:||.                    ||
  Fly    89 ------ANYLRR----VRQVLNE--------------------PR-------------------- 103

  Fly   420 DKSDNEEQLHVPTDFLKPHQDAQLKAKNLYRSCVNSAVLAKRGLEPLHTLIRELGGWPVLESQ-W 483
                      :.||     :..:::.|..|.||:::|.|..:....|.:::||.||.|.:|.: |
  Fly   104 ----------ISTD-----RPMEVRVKYFYESCLDTAALRTKQRSHLLSVLREFGGMPAVEGKSW 153

  Fly   484 SESNFN-WQVLAATLRRYNNDILIVQWVGADIKNSEENIVQFDQTGLGLPTREYFLQPSNAKYLQ 547
            ....|: .:::|..||||....|:..:|..|..||:...:|..|. |.|...:.|     |...:
  Fly   154 DYVGFDAIEMMAQLLRRYGKLTLLGVYVVPDHFNSQIKRLQLGQR-LDLAESDEF-----ASLWK 212

  Fly   548 AYQRYMAEVMHKMGASKADAQRVASELVAFETQLAGITAPAEQRLN-VTKLYKRMTL--DQLQAV 609
            .|...| .:.:.:|.|:..|::.|.|::..|.:|:  .:..:.|:| ..:|.:.:|:  :...|.
  Fly   213 KYALKM-RLRNLLGLSEELARKTAEEIIELELELS--RSAFDHRMNRDPRLMRHLTMLSNMSDAY 274

  Fly   610 VPEIKWRAYLQSLQDREVLGTE---EVVIYAVEYMSKLVTLLDETDPRTVSNYMM---------- 661
            .|.:....::.|.     ||:|   .|......|:.::..:|..|....|:|||:
  Fly   275 GPILNVTRFVTSW-----LGSEYNLPVFESVPSYLFQVKKILLSTPNHVVANYMLSSLLTDFEIT 334

  Fly   662 -----WRFVRHRINNVDDRFDD-IKQSFYHALFGREESPQRWKVCIAQVNTNMGMAVGSMFVSRY 720
                 .:.:.|  ..:.:.|.| :....||:|              .|.|..:...:.|::|
  Fly   335 ANEEQQKVICH--ERITELFPDVVDHMVYHSL--------------EQQNPYIANEMRSLWV--- 380

  Fly   721 FDNNSKRDTLRMTHDLQQAFRDILKTTD--WLDDTTKQLAEEKVNAMSLKIGYPDFILNPSELNS 783
                          :|:.:||::|.:.|  ||:..|::...||:|.||.:|.....:    ....
  Fly   381 --------------ELKSSFREMLSSPDIEWLEKQTREELLEKLNGMSFEIAGGQAV----NFEE 427

  Fly   784 KYAGIEIYPEKYFEN---TLNVLLHTAKTEQAKLHERVNKTNWQTAPAIVNAYYSRNKNQIMFPA 845
            ::..:.:....|:.|   .|.|.....:|:..:....|...:..||..|    |....|.::.|.
  Fly   428 QFGDLVVSSADYYGNIQRLLEVKARILRTDLLRESSSVYYYHGVTATPI----YETETNLVVLPV 488

  Fly   846 GILQPPFYHRH-----FPKSLNFGGIGVVIGHELTHGFDDKGRLFDRNGNIHKWWTDSSIRGFDE 905
            ..:|    ||:     :|.:|.:|.:|..:.||:.|||||..||:|..||::..|:..:..||:.
  Fly   489 SYMQ----HRYLWDDIYPAALKYGTLGFTMAHEMAHGFDDLNRLYDSRGNLNDNWSTQTKVGFEL 549

  Fly   906 RARCIIAQYSNYTVEEVGIVLNGE------STQGENIADNGGLRQAFHAYQRWLKEHPSEVSDEI 964
            ...|:..|:|.        :|.|.      .:|.|:||||.|:|.|..||.:||.:...| ..|.
  Fly   550 VKNCLADQFSG--------MLYGNLRLRRLKSQAESIADNVGIRIAQSAYWKWLDQVEME-ETES 605

  Fly   965 LPGLNMTGPQLFFLNFGQVWCGAMRPEAIRNKLNTAIHSPGRFRVIGTLSNSVDFAREFNCPLGS 1029
            ||.:..:..|||||:..|..|..:.||...|.:....|.|...||...:.||..||..|.|...|
  Fly   606 LPHMTQSPEQLFFLSAAQFMCSDIYPERRANFVRNNFHPPYEARVFAMMINSPAFAEAFQCSNSS 670

  Fly  1030 PMNPQKKCSVW 1040
            .|||..||.::
  Fly   671 KMNPPNKCLMY 681

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nep4	NP_650904.3	M13	274..1038	CDD:189000	189/803 (24%)
Nepl17	NP_651641.1	PepO	49..672	CDD:226118	187/802 (23%)
Nepl17	NP_651641.1	M13	55..678	CDD:189000	188/802 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45454869
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.850