DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nep4 and MME

DIOPT Version :9

Sequence 1:	NP_650904.3	Gene:	Nep4 / 42449	FlyBaseID:	FBgn0038818	Length:	1040	Species:	Drosophila melanogaster
Sequence 2:	NP_000893.2	Gene:	MME / 4311	HGNCID:	7154	Length:	750	Species:	Homo sapiens

Alignment Length:	827	Identity:	275/827 - (33%)
Similarity:	418/827 - (50%)	Gaps:	141/827 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   238 ISEATAALQSFWNEEGTREGIRMTQAKTMKRYMDNKVDPCVDFYKYACGNWERLHPIPKDKAGFD 302
            |:....||.:.:::...:....:..|..:.:.||...:||.||:|||||.|.:.:.||:..:.:.
Human    41 IAVTMIALYATYDDGICKSSDCIKSAARLIQNMDATTEPCTDFFKYACGGWLKRNVIPETSSRYG 105

  Fly   303 TFEMLRESLDLVLRNLLEKNTPVHSAAELRKSPVRNTLFKLNEQGEGEGEADQAAELTAERLRRH 367
            .|::||:.|::||::
Human   106 NFDILRDELEVVLKD-------------------------------------------------- 120

  Fly   368 IVSKRQLLNRVLVRYKRYTNGTKRKRLIETPRERTKEEEAAPPVVLPKDKTKDKSDNEEQLHVPT 432
                                                        ||.:.||:|..
Human   121 --------------------------------------------VLQEPKTEDIV---------- 131

  Fly   433 DFLKPHQDAQLKAKNLYRSCVNSAVLAKRGLEPLHTLIRELGGWPVLESQWSES-NFNW---QVL 493
                    |..|||.|||||:|.:.:..||.|||..|:.::.||||....|.:. ..:|   :.:
Human   132 --------AVQKAKALYRSCINESAIDSRGGEPLLKLLPDIYGWPVATENWEQKYGASWTAEKAI 188

  Fly   494 AATLRRYNNDILIVQWVGADIKNSEENIVQFDQTGLGLPTREYFLQPSNAKYLQAYQRY------ 552
            |....:|...:||..:||.|.|||..:::..||..||||:|:|:  .....|.:|...|
Human   189 AQLNSKYGKKVLINLFVGTDDKNSVNHVIHIDQPRLGLPSRDYY--ECTGIYKEACTAYVDFMIS 251

  Fly   553 MAEVMHKMGASKADAQRVASEL---VAFETQLAGITAPAEQRLNVTKLYKRMTLDQLQAVVP-EI 613
            :|.::.:......|..::|.|:   :..|.::|..||..|.|.:...||.:|||.|:|.... ||
Human   252 VARLIRQEERLPIDENQLALEMNKVMELEKEIANATAKPEDRNDPMLLYNKMTLAQIQNNFSLEI 316

  Fly   614 KWRAY--------LQSLQDREVLGTEEVVIYAVEYMSKLVTLLDETDPRTVSNYMMWRFVRHRIN 670
            ..:.:        :.|..:..:...|:||:||.||::||..:|.:...|.:.|.|.|||:...::
Human   317 NGKPFSWLNFTNEIMSTVNISITNEEDVVVYAPEYLTKLKPILTKYSARDLQNLMSWRFIMDLVS 381

  Fly   671 NVDDRFDDIKQSFYHALFGREESPQRWKVCIAQVNTNMGMAVGSMFVSRYFDNNSKRDTLRMTHD 735
            ::...:.:.:.:|..||:|.......|:.|...||.||..|||.::|...|...||.....:...
Human   382 SLSRTYKESRNAFRKALYGTTSETATWRRCANYVNGNMENAVGRLYVEAAFAGESKHVVEDLIAQ 446

  Fly   736 LQQAFRDILKTTDWLDDTTKQLAEEKVNAMSLKIGYPDFIL-NPSELNSKYAGIEIYPEKYFENT 799
            :::.|...|....|:|..||:.||||..|:..:|||||.|: |.::||::|..:....::||||.
Human   447 IREVFIQTLDDLTWMDAETKKRAEEKALAIKERIGYPDDIVSNDNKLNNEYLELNYKEDEYFENI 511

  Fly   800 LNVLLHTAKTEQAKLHERVNKTNWQTAPAIVNAYYSRNKNQIMFPAGILQPPFYHRHFPKSLNFG 864
            :..|..:...:..||.|:|:|..|.:..|:|||:||..:|||:||||||||||:......|||:|
Human   512 IQNLKFSQSKQLKKLREKVDKDEWISGAAVVNAFYSSGRNQIVFPAGILQPPFFSAQQSNSLNYG 576

  Fly   865 GIGVVIGHELTHGFDDKGRLFDRNGNIHKWWTDSSIRGFDERARCIIAQYSNYTVEEV-GIVLNG 928
            |||:|||||:||||||.||.|:::|::..|||..|...|.|:::|::.||.|::.:.. |..|||
Human   577 GIGMVIGHEITHGFDDNGRNFNKDGDLVDWWTQQSASNFKEQSQCMVYQYGNFSWDLAGGQHLNG 641

  Fly   929 ESTQGENIADNGGLRQAFHAYQRWLKEHPSEVSDEILPGLNMTGPQLFFLNFGQVWCGAMRPEAI 993
            .:|.||||||||||.||:.|||.::|::..|   ::||||::...|||||||.|||||..|||..
Human   642 INTLGENIADNGGLGQAYRAYQNYIKKNGEE---KLLPGLDLNHKQLFFLNFAQVWCGTYRPEYA 703

  Fly   994 RNKLNTAIHSPGRFRVIGTLSNSVDFAREFNCPLGSPMNPQKKCSVW 1040
            .|.:.|.:||||.||:||||.||.:|:..|:|...|.|||:|||.||
Human   704 VNSIKTDVHSPGNFRIIGTLQNSAEFSEAFHCRKNSYMNPEKKCRVW 750

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nep4	NP_650904.3	M13	274..1038	CDD:189000	266/787 (34%)
MME	NP_000893.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20
		Stop-transfer sequence. /evidence=ECO:0000255	16..23
		M13	79..748	CDD:189000	266/785 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150930
Domainoid	1	1.000	264	1.000	Domainoid score	I1924
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG61902
OrthoDB	1	1.010	-	-		D157132at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100162
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	10	9.720