DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nep4 and Nepl14

DIOPT Version :9

Sequence 1:	NP_650904.3	Gene:	Nep4 / 42449	FlyBaseID:	FBgn0038818	Length:	1040	Species:	Drosophila melanogaster
Sequence 2:	NP_651097.1	Gene:	Nepl14 / 42700	FlyBaseID:	FBgn0039023	Length:	696	Species:	Drosophila melanogaster

Alignment Length:	844	Identity:	198/844 - (23%)
Similarity:	336/844 - (39%)	Gaps:	231/844 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   246 QSFWNEEGTREGIRMTQAKTMKRYMDNKVDPCVDFYKYACGNWERLHPIPKDKAGFDTFEMLRES 310
            |..:..|.|   :|.::|:.|..:::..:|||||||.||||||         |:.....:.|::.
  Fly    35 QRIYQSEQT---VRRSKAQDMGSHVNKSIDPCVDFYAYACGNW---------KSTLTPQQQLQQQ 87

  Fly   311 LDLVLRNLLEKNTPVHSAAELRKSPVRNTLFKLNEQGEGEGEADQAAELTAERLRRHIVSKRQLL 375
            .|..|..|:|                                         |.:||.
  Fly    88 TDRELLLLVE-----------------------------------------EAVRRE-------- 103

  Fly   376 NRVLVRYKRYTNGTKRKRLIETPRERTKEEEAAPPVVLPKDKTKDKSDNEEQLHVPTDFLKPHQD 440
            :.|:||
  Fly   104 DSVIVR----------------------------------------------------------- 109

  Fly   441 AQLKAKNLYRSCVNSAVLAKRGLEPLHTL---IRELGGWPVLE-SQWS--ESNFNW-QVLAATLR 498
               :||.|::|||::.  |.:..:..|.|   |.:.||:|.:. |||:  ..::|| .||.....
  Fly   110 ---QAKELFKSCVSAQ--AHQSQQQQHFLSEFINQNGGFPAVPGSQWAVHHHDYNWLSVLGGLRL 169

  Fly   499 RYNNDILIVQWVGADIKNSEENIVQFDQTGLGLPTREYFLQPSNAK---YLQAYQRYMAEVMHKM 560
            ||..||||...||.:..|..||.:...:....:||.......|:.:   |.....|..:|:...:
  Fly   170 RYGMDILIGLRVGYNYGNVNENSLYLSEPSTLIPTELCTRNRSDIRDSIYEPLEHRVASELKSWL 234

  Fly   561 GASKADAQRVASELVAFETQLAG-------ITAPAEQRLNVTKLYKRMTLDQLQAVVPEIKWRAY 618
            .....::.|:|:::::||.:|.|       .:..||::|.:.. |.|.||.:....: |:...:|
  Fly   235 ALGHDESARLAADILSFEHELCGGMKGGSFESWDAEEQLYLAN-YTRKTLREFSNSI-ELDLDSY 297

  Fly   619 LQSLQDREVLGTEEVVIYAVEYMSKLVTLLDETDPRTVSNYMMWRFVRHRINNVDDRFDDIKQSF 683
            :::...:::.  :.|.:.|.||..:|...:...:...|:||:|:|.|......:|||
  Fly   298 VRASFGQDIY--KPVYMAAPEYFRQLKRTVSAHNISLVANYIMYRAVSALNFPLDDR-------- 352

  Fly   684 YHALFGREESPQ-RWKVCIAQVNTNMGMAVGSMFVSRYFDNNSKRDTLRMTHDLQQAFRDILKTT 747
                      || |.:.|:.:....:..|:|.::..::...:.:.|...:...|:.|.|..| ..
  Fly   353 ----------PQLRKRECLERTKELLPTALGELYARQFGTEDGRIDLDNLYDTLKTALRQSL-GA 406

  Fly   748 DWLDDTTKQLAEEKVNAMSLKIGYPDF----ILNPSELNSKYAGIEIYPEKYFENTLNVLLHTAK 808
            :||.:.|:::.:||:.  :||:..|.:    ||.          :::....|::| |..||...:
  Fly   407 EWLVEGTQRVGQEKLR--NLKLQMPTYERPVILK----------LQLERGNYWQN-LRQLLGVVQ 458

  Fly   809 TEQAKLHERVNKTNWQTAPA---IVNAYYSRNK-----NQIMFPAGILQPPFYHRHFPKSLNFGG 865
            :      :|.|:...:..||   .|.||.:|.:     .::.....:||||.|...:..::.:..
  Fly   459 S------QRNNRLFEEFLPAPTDPVEAYEARVRLRPVQRRLDMGLALLQPPAYDPRYGHAIRYAT 517

  Fly   866 IGVVIGHELTHGFDD---KGRLFDRNGNIHKWWTDSSIRGFDERARCIIAQYSNYTVEEVGIVLN 927
            :||.:..:|...|||   ...|.:|:.     |...:...:..|:.|...|..||....|
  Fly   518 LGVQLAQQLVMAFDDPHWSVGLLERDN-----WDGQTAWQYHIRSNCFARQVDNYLRPNV----- 572

  Fly   928 GESTQGENIADNGGLRQAFHAYQRWLK-EHP----SEVSDEILPGLNMTGPQLFFLNFGQVWCG- 986
              |...:.|.|:..:..||.||..||. :.|    ::::.|.||.||.:...||||.:.|..|.
  Fly   573 --SATTQLITDSAAINVAFRAYLTWLGFQEPNNDFTKLTKETLPDLNYSNTALFFLAYAQEHCSL 635

  Fly   987 -AMRPEAIRNKLNT---------AIHSPGRFRVIGTLSNSVDFAREFNCPLGSPMNPQKKCSVW 1040
             ..||   |::..|         ..|:..|..|.|.|.|||:||.||.||:||||||..||.::
  Fly   636 EEARP---RDEQGTPEGYLYSARQNHTWTRLLVNGPLRNSVEFASEFRCPIGSPMNPASKCIIY 696

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nep4	NP_650904.3	M13	274..1038	CDD:189000	191/812 (24%)
Nepl14	NP_651097.1	M13	60..693	CDD:189000	190/811 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45454875
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.850