Protein Alignment Nep4 and Nepl12

DIOPT Version :10

• Sequence 1: NP_650904.3
• Gene: Nep4 / 42449
• FlyBaseID: FBgn0038818
• Length: 1040
• Species: Drosophila melanogaster
• Sequence 2: NP_649924.1
• Gene: Nepl12 / 41172
• FlyBaseID: FBgn0037727
• Length: 702
• Species: Drosophila melanogaster
• Alignment Length: 864
• Identity: 217/864 - (25%)
• Similarity: 344/864 - (39%)
• Gaps: 242/864 - (28%)

  Fly   225 REAERHAEEASAEISEATAALQSFWNEEGTREGIRMTQAKTMKRYMDNKVDPCVDFYKYACGNWE 289
            |.....:..:|...|.|...||.:              |:.||.||:..|:||.:||:|||||:.
  Fly    33 RSENSDSNGSSTNRSAAEYQLQEY--------------AEFMKSYMNQSVEPCENFYEYACGNYR 83

  Fly   290 RLHPIPKDKAGFDTFEMLRESLDLVLRNLLEKNTPVHSAAELRKSPVRNTLFKLNEQGEGEGEAD 354
            .:.|                          ::.:|   .:......|..||..:.|
  Fly    84 NVKP--------------------------DRYSP---GSRSNLGDVTYTLIDITE--------- 110

  Fly   355 QAAELTAERLRRHIVSKRQLLNRVLVRYKRYTNGTKRKRLIETPRERTKEEEAAPPVVLPKDKTK 419
                              |||.|:
  Fly   111 ------------------QLLGRM----------------------------------------- 116

  Fly   420 DKSDNEEQLHVPTDFLKPHQDAQLKAKNLYRSCVNSAVLAKRGLEPLH-TLIRELGGWPVLESQ- 482
               |..|.|:|.::.        ..|:..|.:|:.:.:......:|.: :|||.:||:|.::..
  Fly   117 ---DLAEALNVSSEL--------AVAQRFYNACLGANLHPFNAADPAYLSLIRSIGGFPAVDGDA 170

  Fly   483 WSESNFNWQVLAATLRRYNNDILI---------------VQWVGAD-IKNSEENIVQFDQTGLGL 531
            |..|||||..::|.|..|..:.||               :..:|.| |...||||.:       .
  Fly   171 WKASNFNWINMSAHLANYGANGLIRETLQLRYPFEPYTKLPELGFDHIIVHEENISR-------N 228

  Fly   532 PTREYFLQPSNAK-YLQAY---QRYMAEVMHKMGASKADAQRVASELVAFETQLAGITAPAEQRL 592
            .||.:.|...... ||:|:   :..:.|.:..:.|...||..:..:...|:..
  Fly   229 TTRAFRLNEERMHGYLRAFGLPEDRIREAIAGVFAFWRDALEIPPQCEVFDPY------------ 281

  Fly   593 NVTKLYKRMTLDQLQAVVPE------IKWRAYLQSLQDREVLGTEEVVIYAVEYMSKLVTLLDET 651
                        :::.|.|:      |.|    ..|.....|..:   .|.||        ||:.
  Fly   282 ------------RIKRVFPQSEYYYNISW----SGLHSTNKLFCD---FYYVE--------LDKV 319

  Fly   652 DPR---TVSNYMMWRFVRHRINNVDDRFD-DIKQSFYHALFGREESPQRWKVCIAQVNTNMGMAV 712
            ..|   .|:||:..:.:.        ||| .:|...|          || ..|...:..:|....
  Fly   320 CARHRKAVANYLAMKLLY--------RFDPKLKAPRY----------QR-NYCSVTLYQSMRFLF 365

  Fly   713 GSMFVSRYFDNNSKRDTLRMTHDLQQAFRDILKTTDWLDDTTKQLAEEKVNAMSLKIG-YPDFIL 776
            ..::::..|....:.:...|..:|:::.|..|:..||||..::..|..|.:.:..:|| :.|..|
  Fly   366 NKLYMANNFSEAKRLEMSEMVRELRKSLRKALEDADWLDAESRARALLKESRIQPRIGSFQDDAL 430

  Fly   777 NP---SELNSKYAGIEIYPEKYFENTLN---VLLHTAKTEQAKLHERVNKTNWQ---TAPAIVNA 832
            :.   .|:||    :::..::|.|..:|   :::...:.......|..|.|..|   |...:...
  Fly   431 SDRIIREINS----LKVIEDRYAETNINLQHLVVQINRFSSRHFQELTNDTKPQKILTGLQVGAG 491

  Fly   833 YYSRNKNQIMFPAGILQPPFYHRHFPKSLNFGGIGVVIGHELTHGFDDKGRLFDRNGNIHKWWTD 897
            ||:.: |.|...||:::||.|.||.|.||.||.:|.::||||.||||.....||.||::....::
  Fly   492 YYTPD-NSINVMAGVVEPPIYQRHLPISLKFGTLGFIVGHELIHGFDTTSSYFDGNGHMESLLSE 555

  Fly   898 SSIRGFDERARCIIAQYSNYTVEEVGIVLNGESTQGENIADNGGLRQAFHAY---QRWLKEHPSE 959
            .|.:..::||.|.:..|..|.|.|:...:||::|..||||||.|||||..||   ::.|.|||.:
  Fly   556 ISQQALEDRAECYMDYYGKYQVPEISRRVNGKTTLDENIADNSGLRQALTAYRSHRQQLLEHPGQ 620

  Fly   960 --VSDEILPGLNMTGPQLFFLNFGQVWCGAMRPEAIRNKLNTAIHSPGRFRVIGTLSNSVDFARE 1022
              :|| .:|||::|..|||||.|.|::|.....|.....|:. :|:..:|||:|.||||.||...
  Fly   621 ERISD-AMPGLDLTPEQLFFLGFAQLFCSHYEEEHYWKGLSD-VHTFDQFRVLGVLSNSEDFFHA 683

  Fly  1023 FNCPLGSPMNP-QKKCSVW 1040
            :||.:||.|.| .|.|.:|
  Fly   684 YNCSVGSGMRPGAKTCRLW 702

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nep4	NP_650904.3	M13	274..1038	CDD:341056	204/811 (25%)
Nepl12	NP_649924.1	M13	68..700	CDD:341056	204/811 (25%)