DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nep4 and Ece2

DIOPT Version :9

Sequence 1:	NP_650904.3	Gene:	Nep4 / 42449	FlyBaseID:	FBgn0038818	Length:	1040	Species:	Drosophila melanogaster
Sequence 2:	XP_006248635.1	Gene:	Ece2 / 408243	RGDID:	1303039	Length:	912	Species:	Rattus norvegicus

Alignment Length:	774	Identity:	278/774 - (35%)
Similarity:	406/774 - (52%)	Gaps:	121/774 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   270 MDNKVDPCVDFYKYACGNWERLHPIPKDKAGFDTFEMLRESLDLVLRNLLEKNTPVHSAAELRKS 334
            :|..|.||.|||:::||.|.|.:|:|..::.::||..|.:....:|::|||.:|
  Rat   257 LDRGVSPCQDFYQFSCGGWIRRNPLPSGRSRWNTFNSLWDQNQAILKHLLENST----------- 310

  Fly   335 PVRNTLFKLNEQGEGEGEADQAAELTAERLRRHIVSKRQLLNRVLVRYKRYTNGTKRKRLIETPR 399
                    .|...|            |||
  Rat   311 --------FNSSSE------------AER------------------------------------ 319

  Fly   400 ERTKEEEAAPPVVLPKDKTKDKSDNEEQLHVPTDFLKPHQDAQLKAKNLYRSCVNSAVLAKRGLE 464
                                                        |.::.|.||::...:.|.|.:
  Rat   320 --------------------------------------------KTRSFYLSCLHLERIEKLGAK 340

  Fly   465 PLHTLIRELGGWPVLESQWSESNFNWQVLAATLRRYNNDILIVQWVGADIKNSEENIVQFDQTGL 529
            ||..||.::|||.: ...|.|.|| .:||.|....|........:||||.|:|..||:|.||:||
  Rat   341 PLQDLIDKIGGWNI-TGPWDEDNF-MEVLKAVAGTYRAAPFFTVYVGADSKSSNSNIIQVDQSGL 403

  Fly   530 GLPTREYFL-QPSNAKYLQAYQRYMAEVMHKMGASKADAQRVASELVAFETQLAGITAPAEQRLN 593
            .||:|:|:| :.:|.|.|.||..||.|:...:|......:....:::..|.|||.||.|.:||.:
  Rat   404 FLPSRDYYLNRTANEKVLAAYLDYMVELGMLLGGQPTSTRAQMQQVLELEIQLATITVPQDQRRD 468

  Fly   594 VTKLYKRMTLDQLQAVVPEIKWRAYLQSLQDREVLG-TEEVVIYAVEYMSKLVTLLDETDPRTVS 657
            ..|:|.:|::.:||.:.|.:.|..:|..|.....|| :|.||:|..||:.::..|::.|:|..::
  Rat   469 EEKIYHKMSISELQTLAPSMDWLEFLSFLLSPLELGDSEPVVVYGTEYLQQVSELINRTEPSILN 533

  Fly   658 NYMMWRFVRHRINNVDDRFDDIKQSFYHALFGREES-PQRWKVCIAQVNTNMGMAVGSMFVSRYF 721
            ||::|..|:...:::|.||:..::.....|:|.::| ..||:.||:..:..:|.|:||:||...|
  Rat   534 NYLIWNLVQKTTSSLDQRFETAQEKLLETLYGTKKSCTPRWQTCISNTDDALGFALGSLFVKATF 598

  Fly   722 DNNSKRDTLRMTHDLQQAFRDILKTTDWLDDTTKQLAEEKVNAMSLKIGYPDFILNPSELNSKYA 786
            |..||.....|..:::.||.:.|:...|:|:.|:..|:||.:|:...||:|||||.|.||:..|.
  Rat   599 DRQSKEIAEGMISEIRAAFEETLENLVWMDEKTRLAAKEKADAIYDMIGFPDFILEPRELDDVYD 663

  Fly   787 GIEIYPEKYFENTLNVLLHTAKTEQAKLHERVNKTNWQTAPAIVNAYYSRNKNQIMFPAGILQPP 851
            |.|:..:.:|:|.||:...:||....:|.:..::..|...|..|||||...||:|:|||||||.|
  Rat   664 GYEVSEDSFFQNMLNLYNFSAKVMADQLRKPPSRDQWSMTPQTVNAYYLPTKNEIVFPAGILQAP 728

  Fly   852 FYHRHFPKSLNFGGIGVVIGHELTHGFDDKGRLFDRNGNIHKWWTDSSIRGFDERARCIIAQYSN 916
            ||..:.||:|||||||||:||||||.|||:||.:|:.||:..||.:.|:..|.....|:..||:.
  Rat   729 FYAHNHPKALNFGGIGVVMGHELTHAFDDQGREYDQEGNLRPWWQNESLTAFQNHTACMEEQYNQ 793

  Fly   917 YTVEEVGIVLNGESTQGENIADNGGLRQAFHAYQRWLKEHPSEVSDEILPGLNMTGPQLFFLNFG 981
            |.|.  |..|||..|.||||||||||:.|::||:.||::|..|   :.||.:.:|..||||:.|.
  Rat   794 YQVN--GERLNGLQTLGENIADNGGLKAAYNAYKAWLRKHGEE---QPLPAVGLTNHQLFFVGFA 853

  Fly   982 QVWCGAMRPEAIRNKLNTAIHSPGRFRVIGTLSNSVDFAREFNCPLGSPMNPQKKCSVW 1040
            ||||....||:....|.|..|||.||||:||||||.||.|.|.||:||||||.:.|.||
  Rat   854 QVWCSVRTPESSHEGLVTDPHSPARFRVLGTLSNSRDFLRHFGCPVGSPMNPGQLCEVW 912

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nep4	NP_650904.3	M13	274..1038	CDD:189000	274/766 (36%)
Ece2	XP_006248635.1	AdoMet_MTases	63..>128	CDD:302624
		PepO	250..903	CDD:226118	271/763 (36%)
		M13	261..910	CDD:189000	274/766 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166344495
Domainoid	1	1.000	47	1.000	Domainoid score	I11668
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG61902
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100162
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.760