Protein Alignment Nep4 and KEL

DIOPT Version :9

• Sequence 1: NP_650904.3
• Gene: Nep4 / 42449
• FlyBaseID: FBgn0038818
• Length: 1040
• Species: Drosophila melanogaster
• Sequence 2: XP_005250050.1
• Gene: KEL / 3792
• HGNCID: 6308
• Length: 744
• Species: Homo sapiens
• Alignment Length: 883
• Identity: 196/883 - (22%)
• Similarity: 341/883 - (38%)
• Gaps: 218/883 - (24%)

  Fly   225 REAERHAEEASAEISEATAALQSFWNEEGTRE--------------------------------- 256
            :|....:||...|.|:| ..:.:.|::|.|.|
Human    13 QEGGDQSEEEPRERSQA-GGMGTLWSQESTPEERLPVEGSRPWAVARRVLTAILILGLLLCFSVL 76

  Fly   257 --------GIRMTQAKTMKRYMDN-------KVDPCVDFYKYACGNWERLHPIPKDKAGFDTFEM 306
                    |.|..:........|:       .|.||.||:.:|||..:
Human    77 LFYNFQNCGPRPCETSVCLDLRDHYLASGNTSVAPCTDFFSFACGRAK----------------- 124

  Fly   307 LRESLDLVLRNLLEKNTPVHSAAELRKSPVRNTLFKLNEQGEGEGEADQAAELTAERLRRHIVSK 371
                         |.|......|...|:.:|..|...|....|.||.
Human   125 -------------ETNNSFQELATKNKNRLRRILEVQNSWHPGSGEE------------------ 158

  Fly   372 RQLLNRVLVRYKRYTNGTKRKRLIETPRERTKEEEAAPPVVLPKDKTKDKSDNEEQLHVPTDFLK 436
                                                                             
Human   159 ----------------------------------------------------------------- 158

  Fly   437 PHQDAQLKAKNLYRSCVNSAVLAKRGLEPLHTLIRELGGWPVLESQWSESNFNWQVLAATLRRYN 501
                   ||...|.||:::..:...|..||..:|.|||||.: ..:|:..||| :.|...:.:|.
Human   159 -------KAFQFYNSCMDTLAIEAAGTGPLRQVIEELGGWRI-SGKWTSLNFN-RTLRLLMSQYG 214

  Fly   502 NDILIVQWVGADIKNSEENIVQFDQTGLGLPTREYFLQPSNAKYLQAYQRYMAEVMHKMGASKAD 566
            :......::|....:....::|.||....:|.::...|...|:..:.|..|:.::...:|...:.
Human   215 HFPFFRAYLGPHPASPHTPVIQIDQPEFDVPLKQDQEQKIYAQIFREYLTYLNQLGTLLGGDPSK 279

  Fly   567 AQRVASELVAFETQLAGITAPAEQRLNVTKLYKRMTLDQLQAVVPEIKWRAYLQ-SLQDREVLGT 630
            .|..:|..::..::|.....|.|||....||::.:|:|||:.:.|.|.|.:.|| :.....:..:
Human   280 VQEHSSLSISITSRLFQFLRPLEQRRAQGKLFQMVTIDQLKEMAPAIDWLSCLQATFTPMSLSPS 344

  Fly   631 EEVVIYAVEY---MSKLV--TLLDETDPRTVSNYMMWRFVRHRINNVDDRFDDIKQSFYHALFGR 690
            :.:|::.|||   ||:||  .||.:.|  .:.::|:...|......:|.:|.:.::.....|...
Human   345 QSLVVHDVEYLKNMSQLVEEMLLKQRD--FLQSHMILGLVVTLSPALDSQFQEARRKLSQKLREL 407

  Fly   691 EESP-----QRWKVCIAQVNTNMGMAVGSMFVSRYFDNNSKRDTLRMTHDLQQAFRDILKTTDWL 750
            .|.|     .||..|:.:..|.....:.::||...|..:::...:::...::.|....|:...|:
Human   408 TEQPPMPARPRWMKCVEETGTFFEPTLAALFVREAFGPSTRSAAMKLFTAIRDALITRLRNLPWM 472

  Fly   751 DDTTKQLAEEKVNAMSLKIGYPDFILNPSELNSKYAGIEIYPEKYFENTLNVLLHTAKTEQAKLH 815
            ::.|:.:|::||..:.:::|..::.|.|.....:|..|::     ..:.|..:|...::.:|::.
Human   473 NEETQNMAQDKVAQLQVEMGASEWALKPELARQEYNDIQL-----GSSFLQSVLSCVRSLRARIV 532

  Fly   816 ERVNKTN----WQTAPAIVNAYYSRNKNQIMFPAGILQPPFYHRHFPKSLNFGGIGVVIGHELTH 876
            :...:.:    |:.:|..||||||.:.:.::||||:|||||:|..:|:::|||..|.::.|||.|
Human   533 QSFLQPHPQHRWKVSPWDVNAYYSVSDHVVVFPAGLLQPPFFHPGYPRAVNFGAAGSIMAHELLH 597

  Fly   877 GFDD----KGRLFDRNGNIHKWWTDSSIRGFDERARCIIAQYSNYTVEEVGIVLNGESTQGENIA 937
            .|..    .|.|...|            ....|...|:...|:.:.:.. ....|...|..||.|
Human   598 IFYQLLLPGGCLACDN------------HALQEAHLCLKRHYAAFPLPS-RTSFNDSLTFLENAA 649

  Fly   938 DNGGLRQAFHAYQRWLKEHPSEVSDEILPGLNMTGPQLFFLNFGQVWCGAMRPEAIRNKLNTAIH 1002
            |.|||..|..||.:.|..|..|.   :||.|:::..|:||.::.||.|....|:...:     .|
Human   650 DVGGLAIALQAYSKRLLRHHGET---VLPSLDLSPQQIFFRSYAQVMCRKPSPQDSHD-----TH 706

  Fly  1003 SPGRFRVIGTLSNSVDFAREFNCPLGSPMNPQKKCSVW 1040
            ||...||.|.||::..|||.|.|..|:.:||..:|.:|
Human   707 SPPHLRVHGPLSSTPAFARYFRCARGALLNPSSRCQLW 744

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nep4	NP_650904.3	M13	274..1038	CDD:189000	181/782 (23%)
KEL	XP_005250050.1	PepO	106..744	CDD:226118	182/787 (23%)
		M13	109..742	CDD:189000	181/782 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150993
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S6404
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.800