DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nep4 and Nepl9

DIOPT Version :9

Sequence 1:	NP_650904.3	Gene:	Nep4 / 42449	FlyBaseID:	FBgn0038818	Length:	1040	Species:	Drosophila melanogaster
Sequence 2:	NP_609815.1	Gene:	Nepl9 / 35020	FlyBaseID:	FBgn0032613	Length:	652	Species:	Drosophila melanogaster

Alignment Length:	870	Identity:	159/870 - (18%)
Similarity:	286/870 - (32%)	Gaps:	287/870 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   219 IRIRERREAERHAEEASAEISEATAALQSFWNEEGTREGIRMTQAKTMKRYMDNKVDPCVDFYKY 283
            |:|...:..|....:...|:.....:.|.|       ..:..:..:.:.:..::.:|||.|||.:
  Fly    13 IQIVRSQNGEDSDSDTEVEMDSEVESGQFF-------SHLYKSNLQQLVKIKNDSMDPCDDFYAH 70

  Fly   284 ACGNWERLHPIPKDKAGFDTFEMLRESLDLVLRNLLEKNTPVHSAAELRKSPVRNTLFKLNEQGE 348
            ||||::               :...|:.|..|...|                       .|:|
  Fly    71 ACGNFD---------------QTKEENSDDFLPPYL-----------------------YNKQ-- 95

  Fly   349 GEGEADQAAELTAERLRRHIVSKRQLLNRVLVRYKRYTNGTKR-KRLIETPRERTKEEEAAPPVV 412
                 |:....|||......:..| |::::      ||...|| :|.:.||...|...|
  Fly    96 -----DRMNFFTAEVGNFETIPGR-LISQL------YTECRKREERNVFTPTRLTSHWE------ 142

  Fly   413 LPKDKTKDKSDNEEQLHVPTDFLKPHQDAQLKAKNLYRSCVNSAVLAKRGLEPLHTLIRELGGWP 477
                :..|:        :|  ||..|::.                               |..||
  Fly   143 ----RMLDE--------IP--FLARHKEV-------------------------------LSSWP 162

  Fly   478 VLESQWSE----SNFNWQVLAATLRRYNNDILIVQWVGAD---IKNSEENIVQFDQTGLGLPTRE 535
            .|:.||..    ...||.||:|.|..:....|:..:...|   :...||           ||.
  Fly   163 FLKHQWERRRLYGQLNWIVLSAQLAAHGLPTLLHIYFALDTIYVSPMEE-----------LPC-- 214

  Fly   536 YFLQPSNAKYLQAYQRYMAEVM----HKMGASKADAQRVASELVAFETQL---------AGITAP 587
                ||.|.    :|..:::|:    |::....:...||....:..|..|         ...:.|
  Fly   215 ----PSIAD----FQSSLSDVLEGRHHQVSRIISHEMRVLCREMRGELPLVRSLSQNTRTNTSRP 271

  Fly   588 AEQRLNVTKLYKRMTLDQLQAVVPEIKWRAYLQSLQDREVLGTEEVVIYAVEYMSKLVTLLDETD 652
            .|::|    |....|:|..|      ::.|.|...::| ::|..:..: .||.:::...:|..|:
  Fly   272 GEEQL----LLDENTMDYFQ------QYFAALNFSEER-LVGARKFPL-DVEKITQAWEVLRHTE 324

  Fly   653 PRTVSNYMMWRFVRHRIN-----NVDDRFDDIKQSFYHALFGREESPQRWKVCIAQVNTNMGMAV 712
            .|.|.||:||: .|.::.     .|.:.|:.:..:.|          .:|.|....::..:.:|.
  Fly   325 TRIVYNYVMWQ-AREQLRYPDCYRVSEEFERLLHAEY----------WQWHVLRRHLSREVALAS 378

  Fly   713 GSMFVSRYFDNNSKRDTLRMTHDLQQAFRDILKTTDWLDDTTKQLAEEK-VNAMSLKIGYPDFIL 776
            ..:..:|:                |:..|..|...||.........|:| :....:...:.:..|
  Fly   379 YQLHTTRF----------------QKLRRSKLSRRDWYGHLWPASVEKKELQVARILQNHAENYL 427

  Fly   777 NPSELNSKYAGIEIYPEKYFENTLNVLLHTAKTEQAKLHERVNKTNWQTAPAIVNAYYSRNKNQI 841
            |.:|||..|.|:::....::.|.|  :|..|                |...:.|:.|....
  Fly   428 NITELNENYEGLKLEKNSFYANLL--ILRRA----------------QLRHSFVSPYVDEE---- 470

  Fly   842 MFPAGILQPPFYHRHFPKSLNFGGIGVVIG-------HELTHGFD---DKGRLFDRNGNIHKWWT 896
                .:.||.::.|||   |:|    |::.       :..|||.:   :...|.|.:|  |....
  Fly   471 ----DVNQPAYFLRHF---LHF----VLLSLHRPTYHYYATHGLELWRESRLLLDTDG--HYTAM 522

  Fly   897 D----SSIRGFDERARCIIAQYSNYTVEEVGIVLNGESTQGENIADNGGLRQAFHAYQRWLKEHP 957
            |    .|.:.:|.:...|.....::.:.|:                    .|.:.::|..|.::.
  Fly   523 DCLERQSFQHYDAKLAPIYRPLGSHEIAEI--------------------FQFYRSFQYSLTDYH 567

  Fly   958 SEVSDE--------ILPGLNMTGPQLFFLNFGQVWCGAMRPEAIRNKLNTAIHSPGRFRVIGTLS 1014
            ..:..|        :|....:...::.|....|..|. .:.|....:||..            ..
  Fly   568 FWLQGERFAFAETFVLDYFGLNPHRVLFYAVAQQLCN-RQTEIFAAQLNRG------------YM 619

  Fly  1015 NSVDFAREFNCPLGSPMNPQKKCSV 1039
            |..:|...|.|.....|||..:|.:
  Fly   620 NLPEFQEAFKCGAEKAMNPPSRCMI 644

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nep4	NP_650904.3	M13	274..1038	CDD:189000	152/812 (19%)
Nepl9	NP_609815.1	GluZincin	62..>84	CDD:301352	11/36 (31%)
Nepl9	NP_609815.1	GluZincin	<579..642	CDD:301352	14/75 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45454969
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840