DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nep4 and Nepl7

DIOPT Version :9

Sequence 1:	NP_650904.3	Gene:	Nep4 / 42449	FlyBaseID:	FBgn0038818	Length:	1040	Species:	Drosophila melanogaster
Sequence 2:	NP_001285879.1	Gene:	Nepl7 / 34671	FlyBaseID:	FBgn0032442	Length:	669	Species:	Drosophila melanogaster

Alignment Length:	819	Identity:	206/819 - (25%)
Similarity:	323/819 - (39%)	Gaps:	245/819 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   270 MDNKVDPCVDFYKYACGNWERLHPIPKDKAGFDTFEMLRESLDLVLRNLLEKNTPVHSAAELRKS 334
            |:..:|||.:||:::||.|::...:|:.
  Fly    48 MNRTIDPCENFYEFSCGGWKKADLVPEQ------------------------------------- 75

  Fly   335 PVRNTLF------KLNEQGEGEGEADQAAELTAERLRRHIVSKRQLLNRVLVRYKRYTNGTKRKR 393
             .|||.|      |::||.:|                                  ...|.|||:.
  Fly    76 -ARNTSFLNAIQHKIDEQIQG----------------------------------FLQNATKREL 105

  Fly   394 LIETPRERTKEEEAAPPVVLPKDKTKDKSDNEEQLHVPTDFLKPHQDAQLKAKNLYRSCVNSAVL 458
                                            |.|.|     .....|::|||..|.|||.
  Fly   106 --------------------------------EDLGV-----NGTTSAEIKAKQFYASCVE---- 129

  Fly   459 AKRGLEPLHTLIRELGGWPVLES----QWSESNFN-----WQVLA------ATLRRYNNDILIVQ 508
            .|..|...:....|..|..:.|.    .|...||.     :.:||      .:.|::  |||:..
  Fly   130 MKANLSLGYQYFMEHDGDRLKERNATYDWMYINFMSKYDIYPLLALKVHYSTSSRKF--DILLTL 192

  Fly   509 WVGADIKNSEENIVQFDQTGLGLPTREYFLQPSNAKYLQAYQRYMAEVMHKMGASKADAQRVASE 573
                    ..:.:..|.:..|...|||:.|..|..|..|..:.:                   :.
  Fly   193 --------PSKVLAGFSEEQLKNMTREFGLDSSAEKVKQFVENF-------------------NN 230

  Fly   574 LVAFETQLAGITAPAE--QRLNVTKLYKRMTLDQLQAVVPEIKWRAYLQSLQDREVLGTEE---V 633
            |..||..|..:.....  ::||..:...:...|:|       .|..:.:...:    |::|   .
  Fly   231 LTQFERNLVSLAKSRNETEQLNFKEFLVKHKHDRL-------NWTRFFELAFN----GSQESHWP 284

  Fly   634 VIYAVEYMSKLVTLLDETDPRTVSNYMMWRFVRHRINNVDDRFDDIKQSFYHALFGREESPQRWK 698
            |:..::.::.||..|::|:..|:..|:..|             :.:|  ||..          ||
  Fly   285 VLNQLDNINDLVFFLEQTNLETLKGYIKMR-------------ELVK--FYGL----------WK 324

  Fly   699 V----------CIAQVNTNMGMAVGSMFVSRYFDNNSKRDTLRMTHDLQQAFRDILKTTDWLDDT 753
            .          |.:...|....|:...|:.:.||...:.|.|.:..|::..|.|:|....|||:.
  Fly   325 TQTKTGGVQSECRSLSETYFNYALLPWFIGKVFDKERRADILSVAKDIKDTFYDLLDHHTWLDED 389

  Fly   754 TKQLAEEKVNAMSLKIGYPDFILNPSELNSKYAGIEIYPEKYFENTLNVLLHTAKTEQAKLHERV 818
            |:..|:.|:.:|.:.:||.|.:.:...::..|:.|.: ...:||| |.:|      |.::...|:
  Fly   390 TRSQAKTKLASMDILVGYTDDLQHREVIDGVYSDINM-TGNWFEN-LCIL------EGSRARIRL 446

  Fly   819 NKTNWQTAPAI-----VNAYYSRNKNQIMFPAGILQPPFYHRHFPKSLNFGGIGVVIGHELTHGF 878
            ...:....|.:     |||||:...|......|:.|.||||..||..|.:.|:|.:||||:.|||
  Fly   447 RSVDKALIPLLMPTRTVNAYYADFLNLAFITIGMAQWPFYHIDFPDVLKYAGVGNIIGHEMAHGF 511

  Fly   879 DDKGRLFDRNGNIHKWWTDSSIRGFDERARCIIAQYSNYTVEEVGIVLNGESTQGENIADNGGLR 943
            |.....::.:|....||:.:|:|.|.||.||:.:||:.:.:  :|:..||..|.|:|||||.|.|
  Fly   512 DSYCYQYNYDGKKTNWWSSASLRNFKERYRCLESQYNKFIL--MGVQTNGSLTSGDNIADNVGTR 574

  Fly   944 QAFHAYQR------WLKEHPSEVSDEILPGLNMTGPQLFFLNFGQVWC-GAMRPEAIRNKLNTAI 1001
            .|::|::|      || |.|       |.|:|....||||:.|.|.|| |....:.:| :|.|.:
  Fly   575 MAYYAFKRKTGDKAWL-EKP-------LRGVNFNNKQLFFVKFAQTWCNGKDNGDKLR-RLKTDV 630

  Fly  1002 HSPGRFRVIGTLSNSVDFAREFNCPLGSPMNPQKKCSVW 1040
            |:...|||.|||||..:|:..|||.||:.|||.|||.||
  Fly   631 HAYDEFRVQGTLSNMPEFSEAFNCKLGTEMNPLKKCVVW 669

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nep4	NP_650904.3	M13	274..1038	CDD:189000	202/811 (25%)
Nepl7	NP_001285879.1	PepO	43..669	CDD:226118	204/817 (25%)
Nepl7	NP_001285879.1	M13	52..666	CDD:189000	201/810 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45454877
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S6404
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.800