DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nep4 and Nepl5

DIOPT Version :9

Sequence 1:	NP_650904.3	Gene:	Nep4 / 42449	FlyBaseID:	FBgn0038818	Length:	1040	Species:	Drosophila melanogaster
Sequence 2:	NP_609022.1	Gene:	Nepl5 / 33892	FlyBaseID:	FBgn0031808	Length:	684	Species:	Drosophila melanogaster

Alignment Length:	828	Identity:	172/828 - (20%)
Similarity:	315/828 - (38%)	Gaps:	216/828 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   256 EGIRMTQAKTMKRYMDNKVDPCVDFYKYACGNW----ERLHPI-----PKDKAGF-------DTF 304
            :.::...|:.::.|||.|..||.:||:||||||    :..|.:     .:|:..:       ||.
  Fly    30 QSVQEMLAEQLQSYMDTKARPCENFYQYACGNWQIQQQEQHSLRDRDWTRDRQRYQGQMLPTDTL 94

  Fly   305 EMLRESLDLVLRNLLEKNTPVHSAAELRKSPVRNTLFKLNEQGEGEGEADQAAELTAERLRRHIV 369
            .::..|::..|..||.:               ||         |...|:|.:
  Fly    95 GLIDHSVNRKLELLLRR---------------RN---------ESSFESDSS------------- 122

  Fly   370 SKRQLLNRVLVRYKRYTNGTKRKRLIETPRERTKEEEAAPPVVLPKDKTKDKSDNEEQLHVPTDF 434
                    :|.:.:.|....||.:    |....|..:..||            .|..|
  Fly   123 --------ILEQMRLYYRSCKRLK----PYNLKKYLQLLPP------------SNSTQ------- 156

  Fly   435 LKPHQDAQLKAKNLYRSCVNSAVLAKRGLEPLHTLIRELGGWPVLESQWSESNFNWQVLAATLRR 499
                                                     ||.:...|....|:|......||.
  Fly   157 -----------------------------------------WPSVGRGWRPERFDWITTLGRLRL 180

  Fly   500 YN-NDILIVQWVGADIKNSEENIVQFDQTGLGLPTREYFL---QPSNAKYLQAYQRYMAEVMHKM 560
            :. |.:|:          .||.:.::|.      :|.|.:   :||..:.....:..|.|::..:
  Fly   181 HGLNGVLL----------REEVLPRWDD------SRNYSIYVNKPSRQETQPMGEGAMIELLLDI 229

  Fly   561 GASKADAQRVASELVAFETQLAGITAPAEQRLNVTKLYKRMTLDQLQAVVPEIKWRAYLQSLQ-D 624
            |.:|..|..:|.::..||.:|..:     |.|...:..:.|.|..|.:.:|:::|.::::.:: |
  Fly   230 GQTKRTANALARQVDDFERKLHRL-----QELEDDEGPREMQLGYLDSYLPQLRWLSFMRQVRID 289

  Fly   625 REVLGTEEVVIYAVEYMSKLVTLLDETDPRTVSNYMMWRFVRHRINNVDDRFDDIKQSFYHALFG 689
            .|:.....::|..:.|:..|..|::...|.||.:|:|.:::                     .|.
  Fly   290 SELDLRSTLIIENIPYLRALSDLMESESPDTVCSYIMLKWL---------------------AFL 333

  Fly   690 REESP---QRWKVCIAQVNTNMGMAVGSMFVSRYFDNNSKRDTLRMTHDLQQAFRDILKTTDW-L 750
            :::.|   .|.: |:|.:...|.:|...:...::.|..|:.....:...|:..|..||..... |
  Fly   334 KQQGPADISRGE-CVAALRRAMPLASSWLVGQQFSDPESESYVSSLFQRLKVRFGQILAENRMRL 397

  Fly   751 DDTTKQLAEEKVNAMSLKIGYPDFILNPSE-LNSKYAGIEIYPEKYFENTLNVLLHTAKTEQAKL 814
            ......:.::|:.|:.|::|:  |.....| :...:..|::....::.|.|.:|....:.....|
  Fly   398 SPPLVHILQQKLRAVRLQMGF--FQTEEIEDVEQYHVRIDLSGHSFYGNQLVLLRQRVEANHDLL 460

  Fly   815 HERVNKTN---------------WQTAPAIVNAYYSRNKNQIMFPAGILQPPFYHRHFPKSLNFG 864
            :  :|.||               |:.:.:  :..|.|.:|.::.|.|:||.|.:||:........
  Fly   461 Y--INVTNFANSTGSNLSYLSESWEASNS--SPLYVRPRNLVLVPHGLLQLPIWHRNISALQQHA 521

  Fly   865 GIGVVIGHELTHGFDDKGRLFDRNGNIHKWWTD-SSIRGFDERARCIIAQYSNYTVEEVGIVLNG 928
            .:|.|:.|||.||||..|..:|..|||.....: .:.|.|.:..:|:..|           :..|
  Fly   522 VMGFVLAHELAHGFDMLGMDYDAMGNIMGPVEEIGASRQFRQGLQCLQQQ-----------MATG 575

  Fly   929 ESTQGENIADNGGLRQAFHAYQRWLKEHPSEVSDEILPGLNMTGPQLFFLNFGQVWCGAMRPEAI 993
            .....|.:||...||.|:..:  :......|..|.:||..:..  ||||:.|.|.:||.....:.
  Fly   576 SKWIDEKLADFVALRLAYETF--FGVRDKREPRDPLLPQFSQR--QLFFITFAQFFCGRTPVLSP 636

  Fly   994 RNKLNTAI-HSPGRFRVIGTLSNSVDFAREFNCPLGSPMNPQKKCSVW 1040
            |::....: |:....||:.||:|..:|:|||.|...:.|...::|.:|
  Fly   637 RSQSEAHLKHAADELRVMQTLANFEEFSREFGCDKKAKMQASQRCRIW 684

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nep4	NP_650904.3	M13	274..1038	CDD:189000	165/806 (20%)
Nepl5	NP_609022.1	PepO	42..684	CDD:226118	170/814 (21%)
Nepl5	NP_609022.1	GluZincin	48..682	CDD:301352	165/806 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45454863
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.850