DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nep4 and Nep3

DIOPT Version :9

Sequence 1:	NP_650904.3	Gene:	Nep4 / 42449	FlyBaseID:	FBgn0038818	Length:	1040	Species:	Drosophila melanogaster
Sequence 2:	NP_001245775.1	Gene:	Nep3 / 33005	FlyBaseID:	FBgn0031081	Length:	786	Species:	Drosophila melanogaster

Alignment Length:	786	Identity:	280/786 - (35%)
Similarity:	414/786 - (52%)	Gaps:	133/786 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   270 MDNKVDPCVDFYKYACGNWERLHPIPKDKAGFDTFEMLRESLDLVLRNLLEKNTPVHSAAELRKS 334
            :|..||||.|||.|:|..|.:.:|||:.|:.:.||..|.:...|::||:|||
  Fly   119 IDVTVDPCDDFYGYSCNQWIKNNPIPEGKSTWGTFGKLEQMNQLIIRNVLEK------------- 170

  Fly   335 PVRNTLFKLNEQGEGEGEADQAAELTAERLRRHIVSKRQLLNRVLVRYKRYTNGTKRKRLIETPR 399
            |.::  ||
  Fly   171 PAKS--FK--------------------------------------------------------- 176

  Fly   400 ERTKEEEAAPPVVLPKDKTKDKSDNEEQLHVPTDFLKPHQDAQLKAKNLYRSCVNS-AVLAKRGL 463
                                                   .||:.|||..|.||::: ..:.|.|.
  Fly   177 ---------------------------------------SDAERKAKVYYESCLDADEHMEKLGA 202

  Fly   464 EPLHTLIRELGGWPVLESQWSESNFNWQVLAATLR----RYNNDILIVQWVGADIKNSEENIVQF 524
            :|::.|:.::|||.|.:|.::.:  || .:..||:    :||.:.|....:|.|.|||..:::|.
  Fly   203 KPMNDLLLQIGGWNVTKSGYNVA--NW-TMGHTLKILHNKYNFNCLFGWAIGEDDKNSSRHVIQI 264

  Fly   525 DQTGLGLPTREYF--LQPSNAKYLQAYQRYMAEVMHKMGASKADAQRVASELVAFETQLAGITAP 587
            ||.||.|||.:|:  ...::.|.|..|..||.:|...:||:::||:.....::.||.:||.||.|
  Fly   265 DQGGLTLPTADYYNNKTDNHRKVLNEYIEYMTKVCVLLGANESDARAQMIGVINFEKKLANITIP 329

  Fly   588 AEQRLNVTKLYKRMTLDQLQAVVPEIKWRAYLQS---LQDREVLGTEEVVIYAVEY---MSKLVT 646
            .|.|.|...:|..|.|.||..:.|.:.|..:..:   :..|.|...|.||:||.::   :|.::.
  Fly   330 LEDRRNEEAMYHPMQLRQLSKLAPFLNWTDHFDNAMQMVGRRVTDDEVVVVYAPDFLKNLSDIIL 394

  Fly   647 LLDETDPR--TVSNYMMWRFVRHRINNVDDRFDDIKQSFYHALFGREESPQRWKVCIAQVNTNMG 709
            .:::|:..  |::||::|:.||...:.:...|.|..:....||.|.:...:.|:.|::..|..:|
  Fly   395 KMEQTEEGKITLNNYLVWQAVRTLTSCLSKPFRDAYKGVRKALMGSDGGEEIWRYCVSDTNNVVG 459

  Fly   710 MAVGSMFVSRYFDNNSKRDTLRMTHDLQQAFRDILKTTDWLDDTTKQLAEEKVNAMSLKIGYPDF 774
            .|||::||.:.|...||....:|..::::||:..|:...|:|..|::.|.||.|.:|..||:||:
  Fly   460 FAVGAIFVRQAFHGESKPAAEQMIAEIREAFKMNLQNLTWVDKQTREKAIEKANQISDMIGFPDY 524

  Fly   775 ILNPSELNSKYAGIEIYPEKYFENTLNVLLHTAKTEQAKLHERVNKTNWQTAPAIVNAYYSRNKN 839
            ||:|.||:.|||.:.|.|..||||.:.|.::..|:...:|.:.||||||...|..|||||:..||
  Fly   525 ILDPVELDKKYAELNITPNAYFENNIQVAIYNLKSNLKRLDQPVNKTNWGMTPQTVNAYYTPTKN 589

  Fly   840 QIMFPAGILQPPFYHRHFPKSLNFGGIGVVIGHELTHGFDDKGRLFDRNGNIHKWWTDSSIRGFD 904
            ||:|||||||.||:..:.|||||||.:|||:||||||.|||:||.:|:.|||::||...||..|:
  Fly   590 QIVFPAGILQTPFFDINNPKSLNFGAMGVVMGHELTHAFDDQGREYDKFGNINRWWDSKSIERFN 654

  Fly   905 ERARCIIAQYSNYTVEEVGIVLNGESTQGENIADNGGLRQAFHAYQRWLKEHPSEVSDEILPGLN 969
            |::.||..|||.|.:.  |..|||:.|.||||||||||:.|:|||||...:...::..  |||||
  Fly   655 EKSECIARQYSGYKMN--GRTLNGKQTLGENIADNGGLKAAYHAYQRTKSDRDVDILK--LPGLN 715

  Fly   970 MTGPQLFFLNFGQVWCGAMRPEAIRNKLNTAIHSPGRFRVIGTLSNSVDFAREFNCPLGSPMNPQ 1034
            :|..||||::|.||||.:...|....::....|||.:|||||||||..:||..|.|..|..|||.
  Fly   716 LTHSQLFFVSFAQVWCSSTTDETNLLQMEKDPHSPSQFRVIGTLSNMKEFAEVFQCKPGKRMNPT 780

  Fly  1035 KKCSVW 1040
            :||.||
  Fly   781 EKCEVW 786

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nep4	NP_650904.3	M13	274..1038	CDD:189000	276/778 (35%)
Nep3	NP_001245775.1	M13	123..784	CDD:189000	276/778 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45454993
Domainoid	1	1.000	45	1.000	Domainoid score	I12171
eggNOG	1	0.900	-	-		E1_COG3590
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG61902
OrthoDB	1	1.010	-	-		D17125at7147
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100162
Panther	1	1.100	-	-	P	PTHR11733
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2675
SonicParanoid	0	0.000	Not matched by this tool.
	9	8.790