DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nep4 and Nep6

DIOPT Version :9

Sequence 1:	NP_650904.3	Gene:	Nep4 / 42449	FlyBaseID:	FBgn0038818	Length:	1040	Species:	Drosophila melanogaster
Sequence 2:	NP_001245645.1	Gene:	Nep6 / 32234	FlyBaseID:	FBgn0030425	Length:	655	Species:	Drosophila melanogaster

Alignment Length:	819	Identity:	191/819 - (23%)
Similarity:	312/819 - (38%)	Gaps:	219/819 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   258 IRMTQAKTMKRYMDNKVD----PCVDFYKYACGNWERLHPIPKDKAGFDTFEMLRESLDLVLRNL 318
            :::..|:..::.:||..|    ||.:|::||||||
  Fly    20 LKLAAAQDCQQQLDNDTDAEVKPCENFHQYACGNW------------------------------ 54

  Fly   319 LEKNTP--VHSAAELRKSPVRNTLFKLNEQGEGEGEADQAAELTAERLRRHIVSKRQLLNRVLVR 381
             ..||.  :..|.::|...|.|                                    |...|:|
  Fly    55 -YSNTSQRILGAHDMRSKWVAN------------------------------------LKLQLIR 82

  Fly   382 YKRYTNGTKRKRLIETPRERTKEEEAAPPVVLPKDKTKDKSDNEEQLHVPTDFLKPHQDAQLKAK 446
            |                              |.:..:.|.......:...|        |||  .
  Fly    83 Y------------------------------LEESSSTDSFSANTSVTTST--------AQL--G 107

  Fly   447 NLYRSCVNSAVLAKRGLEPLHT----LIRELGGWPVLESQWSESNFNWQVLAATLRRYNND---I 504
            .|||.|:.|.       :.:.|    |.|....:|:|.:. :..:|:|.:..|.||.|...   .
  Fly   108 TLYRCCLLSG-------QSIRTYTDALSRSGANFPLLANH-TGGSFDWVLANAALRTYGAQGLWR 164

  Fly   505 LIVQ--WVGADIKNSEENIVQFDQTGLGLPTREYFLQPSNAKYLQAYQRYMAEVMHKMGASKADA 567
            |:|:  |..||.:.......:||..|......|:.           ||||:..::.::|.....|
  Fly   165 LLVKDNWQSADQRIFYMLPPKFDLLGRDDELNEFL-----------YQRYLKILLLELGLRVRRA 218

  Fly   568 QRVASELVAFETQLAGITA-PAEQRLNVTKLYKRMTLDQLQAVVPEIKWRAYLQSLQDREVLGTE 631
            ..:|.:|||||..|..:.. .|||.|   .|.|..:|..|::.:|.::.:.|.:::.:.....::
  Fly   219 ALLAEKLVAFEKSLQKLLPNDAEQTL---VLRKPQSLKDLESQLPRLELKRYFETILEGIDWDSK 280

  Fly   632 EVVIYA-VEYMSKLVTLLDE--TDPRTVSNYMMWR---FVRHRINNVDDRFDDIKQSFYHALFGR 690
            .:::.| ::|:..|..||.|  :||..:|.:::.:   :...|::: ||:..:.:.   |.|
  Fly   281 TLLLVADLDYLQGLQRLLAEHTSDPMVLSTWLLLQLPAYFELRLHD-DDKLGNQRN---HCL--- 338

  Fly   691 EESPQRWKVCIAQV-NTNMGMAVGSMFVSRYFDNNSKRDTLRMTHDLQQAFRDILKTTDWLDD-- 752
               .|..|:...|: ...|.:.:|..:...|  :.:.:....:..||:|.|..:|..|:..::
  Fly   339 ---EQLRKLMPGQLGRLQMQLVLGESYQDVY--DTAIQQIAVLFRDLKQQFELVLNETEVFNEDL 398

  Fly   753 TTKQLAEEKVNAMSLKIGYPDFILNPSELNSKYAGIEIYPE---KYFENTLNVLLHTAKTEQAKL 814
            .|:.||.:|:.||.|        |.| .|.....|....|:   ....|.|.:.|..||.|..::
  Fly   399 VTRNLARDKLRAMRL--------LTP-RLQDPINGGPGTPQLGGNCDANLLQLSLSQAKLEYRQV 454

  Fly   815 H-ERVNKTNWQTAPAIVNAYYSRNKNQIMFPAGILQPPFYHRHFPKSLN-----FGGIGVVIGHE 873
            . |.|  |:....|..|||||....|:|..|.|::..|...:...|..:     ..|:|.::.||
  Fly   455 FGEPV--TSVPADPLSVNAYYRLKLNRIELPLGLMATPLIQQQCSKEADTRAKLSAGLGYILAHE 517

  Fly   874 LTHGFDDKGRLFDRNGNI-HKWWTDSSIRGFDERARCII-AQYSNYTVEEVGIVLNGESTQGENI 936
            :.|.||..|..:|..|.: :..|:..:|..|..||.|.: .:|||.|:           |..|||
  Fly   518 MVHAFDLDGLNYDATGQLANGQWSARAIIRFGLRAGCYLGVRYSNATL-----------TVNENI 571

  Fly   937 ADNGGLRQAFHAYQRWLKEHPSEVSDEILPGLNMTGPQLFFLNFGQVWCGAMRPEAIRNKLNTAI 1001
            ||..|||.|...|:     |.|          ..|..:.||:.|.|.|||     .:.:....:.
  Fly   572 ADTEGLRLALDTYR-----HRS----------GATNLRTFFVAFAQNWCG-----TVASTSGLSQ 616

  Fly  1002 HSPGRFRVIGTLSNSVDFAREFNCPLGSPMNPQKKCSVW 1040
            |:....||...:.|..:|...|.|...|.|||..||.:|
  Fly   617 HAGHAERVNNVVGNMPEFGDTFECKATSQMNPVNKCHIW 655

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nep4	NP_650904.3	M13	274..1038	CDD:189000	186/799 (23%)
Nep6	NP_001245645.1	PepO	35..655	CDD:226118	187/802 (23%)
Nep6	NP_001245645.1	M13	40..653	CDD:189000	185/795 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45454871
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.850