Protein Alignment Nep4 and Nep1

DIOPT Version :10

• Sequence 1: NP_650904.3
• Gene: Nep4 / 42449
• FlyBaseID: FBgn0038818
• Length: 1040
• Species: Drosophila melanogaster
• Sequence 2: NP_511056.2
• Gene: Nep1 / 31547
• FlyBaseID: FBgn0029843
• Length: 849
• Species: Drosophila melanogaster
• Alignment Length: 812
• Identity: 312/812 - (38%)
• Similarity: 454/812 - (55%)
• Gaps: 140/812 - (17%)

  Fly   249 WNE------EGTREGIRMTQ-----AKTMKRYMDNKVDPCVDFYKYACGNWERLHPIPKDKAGFD 302
            ||:      || ::.|.|||     |.::...||...|||.||::||||.|.::||||:|::...
  Fly   158 WNQDSGSAHEG-QDNICMTQECVRTAASLLSAMDLNSDPCEDFFQYACGTWNKMHPIPEDRSSIS 221

  Fly   303 TFEMLRESLDLVLRNLLEKNTPVHSAAELRKSPVRNTLFKLNEQGEGEGEADQAAELTAERLRRH 367
            |||:|.:...::||.:||:
  Fly   222 TFEVLSDQQQVILRAVLEE---------------------------------------------- 240

  Fly   368 IVSKRQLLNRVLVRYKRYTNGTKRKRLIETPRERTKEEEAAPPVVLPKDKTKDKSDNEEQLHVPT 432
                                                      |:        |:.||:
  Fly   241 ------------------------------------------PI--------DERDNK------- 248

  Fly   433 DFLKPHQDAQLKAKNLYRSCVNSAVLAKRGLEPLHTLIRELGGWPVLESQWS-ESNFNWQVLAAT 496
                    |.:|||..::||::...:.|.|...|..:::.||||||:|..|| .::.:.:.|...
  Fly   249 --------ATIKAKTFFKSCMDIPQIRKIGTGRLKQVLQSLGGWPVIERNWSPPADLSVERLMGQ 305

  Fly   497 LR-RYNNDILIVQWVGADIKNSEENIVQFDQTGLGLPTREYFLQPSNAKYLQAYQRYMAEVMHKM 560
            || .|:..::|..:||||.|||..||:|.||....||:|:|:|:.|:|...:||.|||.:|...:
  Fly   306 LRLNYSEPVMIELYVGADDKNSSVNILQMDQLQYALPSRDYYLKESSANDRRAYHRYMTQVALLL 370

  Fly   561 GASKADAQRVASELVAFETQLAGITAPAEQRLNVTKLYKRMTLDQLQAVVPEIKWRAYLQS---- 621
            ||..|.|.....::|.|||||..::.|...|.:.:.:|::|.|.:||.:|||::|:.|||:
  Fly   371 GADPATAAAELEKVVLFETQLVNVSLPEADRHDTSLVYRKMLLPELQELVPEVQWQEYLQAALGP 435

  Fly   622 ---LQDREVLGTEEVVIYAVEYMSKLVTLLDETDPRTVSNYMMWRFVRHRINNVDDRFDDIKQSF 683
               ||:.|.|     |.|.:.|::::..:|..||.|.|.|||:||.|...::::.|.:...:..|
  Fly   436 GIPLQEDEPL-----VTYGLHYLTEMGKILAHTDRRVVHNYMLWRLVMSLMSHMIDEYQRERVEF 495

  Fly   684 YHALFGREESPQRWKVCIAQVNTNMGMAVGSMFVSRYFDNNSKRDTLRMTHDLQQAFRDILKTTD 748
            ...|.|.:....||..|:...|..:|:|||::|:...|:..||...|.|.|.::.||.::|...|
  Fly   496 RKILMGIQSERTRWSQCVEWTNKKLGVAVGALFIRDNFNQESKEVALEMIHTIRAAFNELLAEND 560

  Fly   749 WLDDTTKQLAEEKVNAMSLKIGYPDFILNPSELNSKYAGIEIYPEKYFENTLNVLLHTAKTEQAK 813
            |:||.|:.:|:||.::|:.:||||:.:.|.:||..:|..:.|.|:.:..|.|::|...::.....
  Fly   561 WMDDETRAVAKEKADSMNERIGYPELLTNATELEQEYVNLTIVPDNFINNVLSILQWESEKMLRL 625

  Fly   814 LHERVNKTNWQTAPAIVNAYYSRNKNQIMFPAGILQPPFYHRHFPKSLNFGGIGVVIGHELTHGF 878
            |.:.|:|..|.|.||:|||:|:.|||.|:||||||||.||.:|||||||:||||||||||:||||
  Fly   626 LRQPVDKEKWTTEPAVVNAFYNPNKNDIVFPAGILQPLFYSQHFPKSLNYGGIGVVIGHEITHGF 690

  Fly   879 DDKGRLFDRNGNIHKWWTDSSIRGFDERARCIIAQYSNYTVEEVGIVLNGESTQGENIADNGGLR 943
            |||||.||:.||:.:||.:::|..|.||.:|:|.|||.|.:.||.:.::|..||||||||||||:
  Fly   691 DDKGRQFDKEGNMMQWWNNATIEAFRERTQCVIDQYSRYKINEVDMFMDGRMTQGENIADNGGLK 755

  Fly   944 QAFHAYQRWLKEHPSEVSDEILPGLNMTGPQLFFLNFGQVWCGAMRPEAIRNKLNTAIHSPGRFR 1008
            |||.||::|...|..|   :.|||||||..||||||:.|:|||:||||....|:.:|:||||..|
  Fly   756 QAFRAYKKWETLHGRE---QQLPGLNMTHDQLFFLNYAQIWCGSMRPEDALTKIRSAVHSPGFVR 817

  Fly  1009 VIGTLSNSVDFAREFNCPLGSPMNPQKKCSVW 1040
            |:|.||||.|||..:.|||||.|||.:|||||
  Fly   818 VLGPLSNSRDFASAYKCPLGSTMNPAEKCSVW 849

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nep4	NP_650904.3	M13	274..1038	CDD:341056	297/772 (38%)
Nep1	NP_511056.2	M13	194..847	CDD:341056	297/771 (39%)