DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nep4 and ECE1

DIOPT Version :9

Sequence 1:	NP_650904.3	Gene:	Nep4 / 42449	FlyBaseID:	FBgn0038818	Length:	1040	Species:	Drosophila melanogaster
Sequence 2:	XP_011539174.1	Gene:	ECE1 / 1889	HGNCID:	3146	Length:	778	Species:	Homo sapiens

Alignment Length:	972	Identity:	313/972 - (32%)
Similarity:	460/972 - (47%)	Gaps:	204/972 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    75 IMRLDGMLAALQLNEQRMRDLRNSHSEVPVYMEDYEALLPEGSTYNDLINEEFILPASKRTQLQI 139
            |:|..|..........|..:..:::....:..||....|.||..|.:.:...|..|.|
Human     5 IIRNAGYKCKFHCPHPRGSNSMSTYKRATLDEEDLVDSLSEGDAYPNGLQVNFHSPRS------- 62

  Fly   140 LAAERARRCQPYRYGNGESMELEERNTLMKDSRTSFLPLGIPRECLGS-GIELDIKPIDEEAYQR 203
                 .:||...|      .::|:|..::    ...|..|:. .||.: ||:
Human    63 -----GQRCWAAR------TQVEKRLVVL----VVLLAAGLV-ACLAALGIQ------------- 98

  Fly   204 QKKRYQDIAPYWLEKIRIRERREAERHAEEASAEISEATAALQSFWNEEGTREGIRMTQAKTMKR 268
                ||..:|                     |..:|||..::.|                 ::..
Human    99 ----YQTRSP---------------------SVCLSEACVSVTS-----------------SILS 121

  Fly   269 YMDNKVDPCVDFYKYACGNWERLHPIPKDKAGFDTFEMLRESLDLVLRNLLEKNTPVHSAAELRK 333
            .||..||||.||:.||||.|.:.:|:|...:.:.||..|.|....::::|||.:|
Human   122 SMDPTVDPCHDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLENST---------- 176

  Fly   334 SPVRNTLFKLNEQGEGEGEADQAAELTAERLRRHIVSKRQLLNRVLVRYKRYTNGTKRKRLIETP 398
                                  |:...|||
Human   177 ----------------------ASVSEAER----------------------------------- 184

  Fly   399 RERTKEEEAAPPVVLPKDKTKDKSDNEEQLHVPTDFLKPHQDAQLKAKNLYRSCVNSAVLAKRGL 463
                                                         ||:..||:|:|...:.:...
Human   185 ---------------------------------------------KAQVYYRACMNETRIEELRA 204

  Fly   464 EPLHTLIRELGGWPVLESQWSESNFNWQVLAATLRRYNNDILIVQWVGADIKNSEENIVQFDQTG 528
            :||..||..||||.: ...|::.||. ..|......|........:|.||.|||..|::|.||:|
Human   205 KPLMELIERLGGWNI-TGPWAKDNFQ-DTLQVVTAHYRTSPFFSVYVSADSKNSNSNVIQVDQSG 267

  Fly   529 LGLPTREYFL-QPSNAKYLQAYQRYMAEVMHKMGASKADAQR-VASELVAFETQLAGITAPAEQR 591
            ||||:|:|:| :..|.|.|..|..||.::...:|....:|.| ...:::.|||.||.||.|.|:|
Human   268 LGLPSRDYYLNKTENEKVLTGYLNYMVQLGKLLGGGDEEAIRPQMQQILDFETALANITIPQEKR 332

  Fly   592 LNVTKLYKRMTLDQLQAVVPEIKWRAYLQSL-QDREVLGTEEVVIYAVEYMSKLVTLLDETDPRT 655
            .:...:|.::|..:||.:.|.|.|..:|.:: ...|:..:|.:|:|..||:.::.||::.||...
Human   333 RDEELIYHKVTAAELQTLAPAINWLPFLNTIFYPVEINESEPIVVYDKEYLEQISTLINTTDRCL 397

  Fly   656 VSNYMMWRFVRHRINNVDDRFDDIKQSFYHALFGREES--PQRWKVCIAQVNTNMGMAVGSMFVS 718
            ::|||:|..||...:.:|.||.|..:.|...::|.:::  | |||.|::....|:|.|:|.|||.
Human   398 LNNYMIWNLVRKTSSFLDQRFQDADEKFMEVMYGTKKTCLP-RWKFCVSDTENNLGFALGPMFVK 461

  Fly   719 RYFDNNSKRDTLRMTHDLQQAFRDILKTTDWLDDTTKQLAEEKVNAMSLKIGYPDFILNPSELNS 783
            ..|..:||.....:..::::||.:.|.|..|:|:.|::.|:||.:|:...||||:||::|.||:.
Human   462 ATFAEDSKSIATEIILEIKKAFEESLSTLKWMDEETRKSAKEKADAIYNMIGYPNFIMDPKELDK 526

  Fly   784 KYAGIEIYPEKYFENTLNVLLHTAKTEQAKLHERVNKTNWQTAPAIVNAYYSRNKNQIMFPAGIL 848
            .:......|:.||||.:.....:.:....:|.:..|:..|...|.:||||||..||:|:||||||
Human   527 VFNDYTAVPDLYFENAMRFFNFSWRVTADQLRKAPNRDQWSMTPPMVNAYYSPTKNEIVFPAGIL 591

  Fly   849 QPPFYHRHFPKSLNFGGIGVVIGHELTHGFDDKGRLFDRNGNIHKWWTDSSIRGFDERARCIIAQ 913
            |.|||.|..||:|||||||||:||||||.|||:||.:|::||:..||.:||:..|..:..|::.|
Human   592 QAPFYTRSSPKALNFGGIGVVVGHELTHAFDDQGREYDKDGNLRPWWKNSSVEAFKRQTECMVEQ 656

  Fly   914 YSNYTVEEVGIVLNGESTQGENIADNGGLRQAFHAYQRWLKEHPSEVSDEILPGLNMTGPQLFFL 978
            ||||:|.  |..:||..|.||||||||||:.|:.|||.|:|::.:|.|   ||.|.:|..|||||
Human   657 YSNYSVN--GEPVNGRHTLGENIADNGGLKAAYRAYQNWVKKNGAEHS---LPTLGLTNNQLFFL 716

  Fly   979 NFGQVWCGAMRPEAIRNKLNTAIHSPGRFRVIGTLSNSVDFAREFNCPLGSPMNPQKKCSVW 1040
            .|.||||....||:....|.|..|||.||||||:||||.:|:..|.||.||||||..||.||
Human   717 GFAQVWCSVRTPESSHEGLITDPHSPSRFRVIGSLSNSKEFSEHFRCPPGSPMNPPHKCEVW 778

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nep4	NP_650904.3	M13	274..1038	CDD:189000	276/768 (36%)
ECE1	XP_011539174.1	PepO	114..769	CDD:226118	274/791 (35%)
ECE1	XP_011539174.1	M13	127..776	CDD:189000	276/768 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150951
Domainoid	1	1.000	48	1.000	Domainoid score	I11915
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG61902
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100162
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2675
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.790