DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nep4 and nep-2

DIOPT Version :9

Sequence 1:	NP_650904.3	Gene:	Nep4 / 42449	FlyBaseID:	FBgn0038818	Length:	1040	Species:	Drosophila melanogaster
Sequence 2:	NP_494343.2	Gene:	nep-2 / 188090	WormBaseID:	WBGene00020230	Length:	736	Species:	Caenorhabditis elegans

Alignment Length:	784	Identity:	266/784 - (33%)
Similarity:	404/784 - (51%)	Gaps:	129/784 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   270 MDNKVDPCVDFYKYACGNWERLHPIPKDKAGFDTFEMLRESLDLVLRNLLEKNTPVHSAAELRKS 334
            |::.||||.|||::|||.|.:.||||.|......||.|.:.|:..|:.||:
Worm    69 MNSSVDPCDDFYEFACGQWIKGHPIPDDAPSVSNFENLGQDLEFALKELLD-------------- 119

  Fly   335 PVRNTLFKLNEQGEGEGEADQAAELTAERLRRHIVSKRQLLNRVLVRYKRYTNGTKRKRLIETPR 399

Worm   120 ----------------------------------------------------------------- 119

  Fly   400 ERTKEEEAAPPVVLPKDKTKDKSDNEEQLHVPTDFLKPHQDAQLKAKNLYRSCVNSAVLAKRGLE 464
                                   :|:|    |.|:   ...|..|||..|..|:|.:.:......
Worm   120 -----------------------ENDE----PYDY---ETSAVGKAKYFYNLCLNESEILDNWRT 154

  Fly   465 PLHTLIRELGGWPVLESQWSESNFNWQVLAATLRRYNNDILIVQWVGADIKNSEENIVQFDQTGL 529
            ....:::..||||.|..|.........:.|..:.::..|.|....|..|.|||:.:::..||..|
Worm   155 TFDEVVKSFGGWPSLGHQMKPDASIEMLYADMVAKFKADSLFKATVQPDDKNSQRHVLLIDQPQL 219

  Fly   530 GLPTREYFLQPSNAKYLQAYQRYMAEVMHKMGASKADAQRVASELVAFETQLAGITAPAEQRLNV 594
            .|..|::::...|.:.: ||.:.:.:|:..:.|.:..|...|.|::.|||.||.||...|.|.::
Worm   220 NLFARDFYVAAENEERM-AYLQLIRDVLILLDADRTRATLDAKEIIDFETALANITMADEHRHDI 283

  Fly   595 TKLYKRMTLDQLQAVVPEIKWRAYLQSL-QD-REVLG-------TEEVVIYAVEYMSKLVTLLDE 650
            .:||.::||.:::..:|...|..:...: :| .|..|       ..|||:|..|::.:|..|:.:
Worm   284 AELYTKITLGEMRRSLPHFNWPLFFNRMFKDLHEKNGKRITFDDNTEVVVYGYEFLRRLDVLIPQ 348

  Fly   651 TDPRTVSNYMMW-RFVRHRINNVDDRFDDIKQSFYHALFGREESPQRWKVCIAQVNTNMGMAVGS 714
            .|.|.:.||:.| .|.:..:.::.|.|......||..|........||..|:.::|:.|.||..:
Worm   349 YDNRLIVNYLEWCWFFKTMLRDLPDPFALTIFKFYKTLNIMNVQKVRWHGCVTRINSLMPMATSA 413

  Fly   715 MFVSRYFDNNSKRDTLRMTHDLQQAFRDILKTTDWLDDTTKQLAEEKVNAMSLKIGYPDFILNPS 779
            ::|..:||:.:|:....|...:.::|.|:|.:.|||...|||.|::|||.|..||||||::.:|:
Worm   414 IYVKNHFDHEAKQQVEEMISLIMESFVDLLLSEDWLTKETKQTAKQKVNEMKRKIGYPDYLNDPA 478

  Fly   780 ELNSKYAGIEIYPEKYFENTLNVLLHTAKTEQAKLHERVNKTNWQTAPAIVNAYYSRNKNQIMFP 844
            .:|::|...::||..|::...:......:....::.|.|::..|....|:|||:||.|.|:|:||
Worm   479 AVNNEYKTFKVYPGHYYQTKFSFYEQYQRDVLERITEAVDRERWVAGAALVNAFYSPNTNEIIFP 543

  Fly   845 AGILQPPFYHRHFPKSLNFGGIGVVIGHELTHGFDDKGRLFDRNGNIHKWWTDSSIRGFDERARC 909
            ||||||.||.:.||.|:||||||||||||:||||||:|||:|..|||.:||.:::|..|:.:|:|
Worm   544 AGILQPVFYSKDFPSSMNFGGIGVVIGHEITHGFDDRGRLYDNLGNIRQWWDNATISKFEHKAQC 608

  Fly   910 IIAQYSNYTVEEVGIVLNGESTQGENIADNGGLRQAFHAYQRWLKEH--PSEVSDEILPGLNMTG 972
            |..|||:|.::::.:.:||:||:||||||||||:||:.||:::.|.|  |..     |||:|:|.
Worm   609 IEKQYSSYVLDQINMQINGKSTKGENIADNGGLKQAYRAYKKYEKRHSRPPR-----LPGVNLTH 668

  Fly   973 PQLFFLNFGQVWCGAMR-PEAIRNKLNTAIHSPGRFRVIGTLSNSVDFAREFNCPLGSPMNPQKK 1036
            .||||||:.|:|||.|. .|||| ||.|:.||||..||.|.||||.|||:.:||..||.|||::|
Worm   669 DQLFFLNYAQIWCGTMNDKEAIR-KLRTSEHSPGPIRVKGPLSNSYDFAKAYNCEPGSQMNPREK 732

  Fly  1037 CSVW 1040
            |.||
Worm   733 CRVW 736

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nep4	NP_650904.3	M13	274..1038	CDD:189000	262/776 (34%)
nep-2	NP_494343.2	PepO	61..736	CDD:226118	264/782 (34%)
nep-2	NP_494343.2	M13	73..734	CDD:189000	262/776 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H22778
Inparanoid	1	1.050	575	1.000	Inparanoid score	I563
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG61902
OrthoDB	1	1.010	-	-		D157132at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100162
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.880