DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nep4 and nep-8

DIOPT Version :9

Sequence 1:	NP_650904.3	Gene:	Nep4 / 42449	FlyBaseID:	FBgn0038818	Length:	1040	Species:	Drosophila melanogaster
Sequence 2:	NP_001309548.1	Gene:	nep-8 / 184631	WormBaseID:	WBGene00017553	Length:	686	Species:	Caenorhabditis elegans

Alignment Length:	787	Identity:	152/787 - (19%)
Similarity:	290/787 - (36%)	Gaps:	220/787 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   260 MTQAKTMKRYMDNKVDPCVDFYKYACGNWERLHPIPKDKAGFDTFEMLRESLDLVLRNLLEKNTP 324
            :|.:..:..|.|..|||||||::::||   |.|
Worm    62 ITLSHELLNYQDPSVDPCVDFFQHSCG---RFH-------------------------------- 91

  Fly   325 VHSAAELRKSPVRNTLFKLNEQGEGEGEADQAAELTAERLRRHIVSK--RQLLNRVLVRYKRYTN 387
                                ||...|....:         ::||:.|  |:.|:::
Worm    92 --------------------EQSVSESRLQK---------KKHILRKQIREFLHKI--------- 118

  Fly   388 GTKRKRLIETPRERTKEEEAAPPVVLPKDKTKDKSDNEEQLHVPTDFLKPHQDAQLKAKNLYRSC 452
                       :..|.:.|....:|..|.:...|:.|        |..|..:||
Worm   119 -----------QNSTSKSENLMKLVFDKCEASKKTSN--------DNYKISRDA----------- 153

  Fly   453 VNSAVLAKRGLEPLHTL---IRELGGWPVLESQWSESNFNWQVLAATLRRYNNDILIVQWVGADI 514
                         :|.:   |:::|.||:|:..|..|.|                        |:
Worm   154 -------------IHDVFNDIKKIGAWPLLDKNWDGSKF------------------------DL 181

  Fly   515 KNSEENIVQFDQTGLGLPTREYFLQPSNAKYLQ------------AYQRYMAEVMHKMGASKADA 567
            .....|:|:...|.|||...::.:. :..|:::            .....::|::...|. :.|:
Worm   182 NEMLSNLVKLGATNLGLFQLDFRIL-TEGKFVRIAPTLGSIVHNSTMISMISEILEANGV-QPDS 244

  Fly   568 QRVASELVAFET--------QLAG---ITAPAEQRLNVTKLYKRMT-LDQLQAVVPEIKWRAYLQ 620
            :.::.|...:.:        |.:|   |:.|..:.:|.:.|...|. ..::..:..:|:
Worm   245 EEISKEFEEYSSLQMKLAKYQSSGKLSISLPGVRSINFSSLITEMIHPSRVSKIFGKIR------ 303

  Fly   621 SLQDREVLGTEEVVIYAVEYMSKLVTLLDETDPRTVSNYMMWRFVRHRINNVDDRFDDIKQSFYH 685
                  |:.:|..:.:.......|.|:::.|..:|::|::::.::               ||.|:
Worm   304 ------VVTSEHPLFFKSNETESLDTIIESTSNKTLANFLIFNYI---------------QSSYN 347

  Fly   686 ALFGREESPQRWKVCIAQVNTNMGMAVGSMFVSRYFDNNSKRDTLRMTHDLQQAFRDILKTTDWL 750
            .:.|.....     |...|......|...:|:..:.|..::....::|.:|::...::::.|:.|
Worm   348 IMKGARRGN-----CEDDVRREFPRASLRVFMRNFVDKGNRDGVKKLTEELKKNTLEMIQDTENL 407

  Fly   751 DDTTKQLAEEKVNAMSLKIGYPDFILNPSELNSKYAGIEI-YPEKYFE--NTLNVLLHTAKTEQA 812
            ....|:...:||.|:.:.|||||....|..|:.::...:: ..:.|:.  ..||.|    ::||
Worm   408 APPVKESMLKKVEAIKVTIGYPDHFDPPGTLDKEFENFDLDSTDSYYRIFQKLNRL----RSEQ- 467

  Fly   813 KLHERVNKTNWQTAPAI--VNAYYSRNKNQIMFPAGILQPPFYHRHFPKSLNFGGIGVVIGHELT 875
            ::.....:|.......:  |||.|.|:||.:...|..|..||:...:|..:|....|.:|.||:.
Worm   468 QMEFIAGETPISPIKEVLKVNANYKRSKNALTVFAPFLDDPFFDITYPDYVNLFFSGFLIAHEIG 532

  Fly   876 HGFDDKGRLFDRNGNIHKWWTDSSIRGFDERARCIIAQYSNYTVEEVGIVLNGESTQGENIADNG 940
            |..|..|..:|.||..........:..:.::.:|::.||.||.....|..:||..:..|.|||..
Worm   533 HSVDANGLGYDENGKPMDGIRLEHVTEYGKQGQCLVDQYDNYDDPVYGKKMNGTHSINEIIADWV 597

  Fly   941 GLRQAFHAYQRWLKEHPSEVSDEI-LPGLNMTGPQLFFLNFGQVWCGAMRPEAIRNKLNTAIHSP 1004
            |....:.||:   |...|::...| |..:||  .||:|.....::|......::...|.. ::..
Worm   598 GHEVTWRAYK---KMDTSKMLSLIGLKDINM--DQLYFRVQSLLFCRERDTISLEETLKD-VYPT 656

  Fly  1005 GRFRVIG 1011
            ..|||.|
Worm   657 DNFRVNG 663

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nep4	NP_650904.3	M13	274..1038	CDD:189000	149/773 (19%)
nep-8	NP_001309548.1	M13	76..664	CDD:341056	149/773 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160161766
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.850