Protein Alignment Nep4 and nep-22

DIOPT Version :10

• Sequence 1: NP_650904.3
• Gene: Nep4 / 42449
• FlyBaseID: FBgn0038818
• Length: 1040
• Species: Drosophila melanogaster
• Sequence 2: NP_509528.1
• Gene: nep-22 / 181144
• WormBaseID: WBGene00020788
• Length: 798
• Species: Caenorhabditis elegans
• Alignment Length: 844
• Identity: 195/844 - (23%)
• Similarity: 337/844 - (39%)
• Gaps: 200/844 - (23%)

  Fly   270 MDNKVDPCVDFYKYACGNWERLHPIPKDKAGFDTFEMLRESLDLVLRNLLEKNTPVHSAAELRKS 334
            :|:.||||.|||.:.|..:
 Worm    79 LDDTVDPCQDFYAFTCNKF---------------------------------------------- 97

  Fly   335 PVRNT-LFKLNEQGEG---EGEADQAAELTAERLRRHIVSKRQLLNRVLVRYKRYTNGTKRKRLI 395
             ::|| |.||.....|   :.:.|..:|:.|...:..:.|               |..:|.:|:.
 Worm    98 -LQNTDLQKLGRSRLGTYDQAQVDVYSEIVAALSKIDVTS---------------TTTSKTERIT 146

  Fly   396 ETPRERTKEEEAAPPVVLPKDKTKDKSDNEEQLHVPTDFLKPHQDAQLKAKNLYRSCVNSAVLAK 460
            :...|..|...|:     |.|||                                    :.|.|:
 Worm   147 KAAFETCKNNLAS-----PADKT------------------------------------AVVYAE 170

  Fly   461 RGLEPLHTLIRELGGWPVLESQWSESNFNWQVLAATLRRYNNDILIVQWVGADIKNSEENIVQFD 525
                    :....||.|........:...|.|.....:::....|......:|.|:..:|.:...
 Worm   171 --------ITSLFGGVPFFGEPLKTNVDYWMVAGQIEQKHAVGTLTYTIASSDYKDHTKNALYTG 227

  Fly   526 QTGLGLPTREYFLQPSNAKYLQAYQRYMAEVMHKM-----------GASK----ADA-QRVASEL 574
            ..||.| .|:::::|          :|:|||..::           .|:|    ||| ...|.|:
 Worm   228 PPGLSL-ARDFYVKP----------QYIAEVNQRVSDVNDLLTAFANAAKKNVGADALLAAAQEV 281

  Fly   575 VAFETQLAGITAPAEQRLNVTKLYKRMTLDQLQAVVPEIKWRAYLQSLQDREVLGTEE----VVI 635
            |.||.|:|..:.|.:...|..:.|....:.........|.|::||..|........::    :|:
 Worm   282 VNFEVQIAMASWPDDLLRNYQQQYNPYNIASATTAYRAINWKSYLGQLFHGVASDADQANYNIVV 346

  Fly   636 YAVEYMSKLVTLLD--ETDPRTVSNYMMWRFVRHR---INNVDDRFDDIKQSFYHAL-------- 687
            ....|.:.|.::.|  .::...|:|||:.:.:...   ||....:........::||
 Worm   347 TEPSYFAWLNSVFDGKTSNSTVVANYMIAQLLADESDFINPATAKVSSDTNYIHYALRNGRGIKK 411

  Fly   688 FGREESPQRWKV---------CIAQVNTNMGMAVGSMFV-SRYFDNNSKRDTLRMTHDLQQAFRD 742
            .|:.|    :::         |:..:...|....|.::| |:...|..:.|....|..:...|:.
 Worm   412 IGKRE----YRMADLDGISEGCMDLLTAYMPYGTGYVYVKSKSERNKVQADVKDQTTLIINNFQG 472

  Fly   743 ILKTTDWLDDTTKQLAEEKVNAMSLKIGYPDFILNP-------SELNSKYAG-IEIYPEKYFENT 799
            ::.:.:|:|..:|..|..|.:::....|:|:.:...       ...|..||. |::| .|...:.
 Worm   473 MIDSLNWMDTFSKNRAHNKSDSLVKNFGWPEAMFGDFNDFTTVDAYNQDYASIIDLY-TKDKNDI 536

  Fly   800 LNVLLHTAKTEQAK-----LHERVNKTNWQTAPAIVNAYYSRNKNQIMFPAGILQPPFYHRHFPK 859
            ..:.....|..:.:     :.|..::||:..:||:|||:|...:|.|.||.....||:|:.::|:
 Worm   537 YGIFAVLKKGMEVREFFRIMGEPADRTNFLQSPAMVNAWYQPERNSITFPYAAWNPPYYNLNYPQ 601

  Fly   860 SLNFGGIGVVIGHELTHGFDDKGRLFDRNGNIH--KW----WTD-SSIRGFDERARCIIAQYSNY 917
            :.||.|.|...|||||||:||:|..|..||.:.  .|    |.| :|..||.:.|:|::.|:|..
 Worm   602 AYNFAGQGGTGGHELTHGYDDEGVQFGFNGELTDCSWNKCGWMDTNSSSGFIDMAQCVVTQFSTQ 666

  Fly   918 TV-EEVGIV--LNGESTQGENIADNGGLRQAFHAYQRWLKEHPSEVSDEILPGL-NMTGPQLFFL 978
            .. |:.|.:  .||.:||||||||.||.:.|:.:|::::......|.::.|||| |.|..|:|::
 Worm   667 CCPEKTGNIHCANGATTQGENIADLGGQQAAYRSYRQYVATTRKGVEEDRLPGLENYTPNQIFWI 731

  Fly   979 NFGQVWCGAMRPEAIRNKLNTAIHSPGRFRVIGTLSNSVDFAREFNCPLGSPMNPQK--KCSVW 1040
            .:|..||.......:.::|.|..|||.:.|....:.:..:|.::|.|..||||.|:.  :|.||
 Worm   732 TYGYSWCMKQSDANLVHQLLTNPHSPAQCRTNQVMQDIPEFGKDFGCVRGSPMYPEPSGRCKVW 795

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nep4	NP_650904.3	M13	274..1038	CDD:341056	191/836 (23%)
nep-22	NP_509528.1	M13	83..793	CDD:341056	191/836 (23%)