Protein Alignment Nep4 and nep-16

DIOPT Version :10

• Sequence 1: NP_650904.3
• Gene: Nep4 / 42449
• FlyBaseID: FBgn0038818
• Length: 1040
• Species: Drosophila melanogaster
• Sequence 2: NP_001023203.2
• Gene: nep-16 / 177541
• WormBaseID: WBGene00018472
• Length: 868
• Species: Caenorhabditis elegans
• Alignment Length: 1030
• Identity: 185/1030 - (17%)
• Similarity: 351/1030 - (34%)
• Gaps: 324/1030 - (31%)

  Fly   109 YEALLPEGSTYNDLINEEFILPASKRTQLQILAAERA--RRCQPYRYGNGESMELEERNTLMKDS 171
            :|:::.|...|:  :.....:|.|....:||..|..|  .....:|....|:.:.||.|....|.
 Worm    61 HESIVREVREYH--LQTTSRIPFSPPPTIQIHPAPIAGPESTSSFRTNPEENRDDEEDNVEETDQ 123

  Fly   172 RTSFLPLGIPRECLGSGIELDIKPIDEEAYQRQKKRYQDIAPYWLEKIRIRERREAERHAEEASA 236
            ...|                   |:.||.....:...|...|   |::...:::..:.:.:....
 Worm   124 EIEF-------------------PVTEERSIDPEITEQPEEP---ERVEDEQQKSGDDNLDNRLT 166

  Fly   237 EISEATA------ALQSFWNEEG-----------------------------TREGIRMTQAKT- 265
            :..||.:      .:..|:..:|                             |.:|.|...||:
 Worm   167 QQLEAPSDRRIIFPITPFYRRKGTCSKCSIWLGALCALFFLLSIALFLVWVITTDGFRTIGAKST 231

  Fly   266 --------------MKRYMDNKVDPCVDFYKYACGNWERLHPIPKDKAGFDTFEMLRESLDLVLR 316
                          :...:|::::||.:||:|:|   :|.|....||
 Worm   232 NVCNTRQCIDIAFRLSSCIDDEIEPCENFYRYSC---QRYHSQTADK------------------ 275

  Fly   317 NLLEKNTPVHSAAELRKSPVRNTLFKLNEQGEGEGEADQAAELTAERLRRHIVSKRQLLNRVLVR 381
                                               :....::|..|.|||        ::.:|
 Worm   276 -----------------------------------QMSFLSQLKDESLRR--------MHSLL-- 295

  Fly   382 YKRYTNGTKRKRLIETPRERTKEEEAAPPVVLPKDKTKDKSDNEEQLHVPTDFLKPHQDAQLKAK 446
                                :.||::.   :|||                        .|:| ::
 Worm   296 --------------------SSEEDSR---LLPK------------------------SARL-SR 312

  Fly   447 NLYRSCVNSAVLAKRGLEPLHTLIRELGGWPVLE--SQWSESNFNWQVLAATL----RRYNNDIL 505
            :||.:|:|:.:.:......|.|.||.....|:|.  ..:...:::|:..|..|    .|||   |
 Worm   313 SLYSACMNAVLRSSNAPTDLLTFIRNFPCGPLLRDCQNFHADSYSWERHAGMLDWYAGRYN---L 374

  Fly   506 IVQWVGADIKNSEENIVQFDQTGL----GLPTREY--FLQPSNAKYLQAYQRYMAEVMHKMGASK 564
            ||.......::..:.|:|.....|    ||..|:.  ..:||..::....|..:.:.:....|..
 Worm   375 IVYDRDVHPQDRSKIILQIKPPDLTPIVGLIERDLIDLARPSPTEFEPLLQLSLRQNLLSAFARD 439

  Fly   565 A---DAQRVASELVAFETQLAGITAPAEQRLNVTKLYKRMTLDQLQAVVPEIKWRAYLQSLQDRE 626
            :   |.:.|.|:|......:..:...|.|..::|.....||:.::...:|::    ||:...|.:
 Worm   440 SLLRDPRDVQSQLDEVARLMVDLYISARQSASLTPNTTYMTIGEMFQALPQL----YLREFLDAQ 500

  Fly   627 VLG------TEEVVIYAVEYMSKLVTLLDETDPRTVSNYMM----WRFVRHRINNVDDRFDDIKQ 681
            :..      |:.:.|...:|.::|..::.:|..:.|:||::    |               ::||
 Worm   501 LSNTYRWTETDMLSIQDYDYFARLSDIMAQTSRQAVANYLLTVTVW---------------NLKQ 550

  Fly   682 SFYHALFGREESPQ---RWKVCIAQVNTNMGMAVG-SMFVSRYFDNNSKRDTLRMTHDLQ--QAF 740
            ..|        ||:   .|:.|:.|:::   ..:| .|:|          |....|.||.  |.|
 Worm   551 YSY--------SPRDQYGWRECVDQISS---FEIGRKMYV----------DKASQTIDLPKIQEF 594

  Fly   741 RDILKTTDWLD---DTTKQLAEEKVNAMSLKIGYPDFILNPSELNSKYAGIEIYPEKYFENTLNV 802
            ...|| .|:|.   .|..|.. ..:|.:...:|:|..:.|...:....:.:.:....||::.:.|
 Worm   595 LQNLK-IDFLSVHRSTPLQYL-SNINRLGFYVGFPRRLQNEELIWKPVSQVSLNETDYFDSMIRV 657

  Fly   803 LLHTAKTEQ----AKLHERVNKTNWQTAP-AIVNAYYSRNKNQIMFPAGILQPPFY--HRHFPKS 860
                .|.|:    :::...::..:..|.| :.....|:.|...|:.|...::||.|  ....|..
 Worm   658 ----GKAERDYTMSQIGTYLDNDDTTTFPISDPTMLYNSNVGAIVIPLAFIEPPIYLPGDEVPMY 718

  Fly   861 LNFGGIGV----VIGHELTHGFDDKGRLFDRNGNIHKWWTDSSIRGFDERARCIIAQYSNYTVEE 921
            ..:..:|:    :|......|.|...:|         ...|:..|||.:..|   .:..|...|.
 Worm   719 GIYSSLGITTLQMISKVFWQGLDKTSQL---------ECLDNVFRGFLDANR---QRSPNIEPEL 771

  Fly   922 VGIVLNGESTQGENIADNGGLRQAFHAYQRWLKEHPSEVSDEILPGLNMT-GPQLFFLNFGQVWC 985
            :..:         .:||  ..:.|.::|.:|..:|... .::.||..:.| ..:...|.|..::|
 Worm   772 LATI---------ELAD--AFKSALYSYAKWQNDHHIH-HEKTLPAFDSTDSMRSLMLTFSTMFC 824

  Fly   986 GAMRPEAIRNKLNTAIHSPGR--FRVIGTLS-NSVDFAREFNCPLGSPMNPQKKC 1037
            .....|            ||.  ..:|.|:: ||..|:..|||...|.:..::.|
 Worm   825 SGEGSE------------PGSDYEAMINTVAENSRMFSIHFNCNNSSRLYNRRTC 867

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nep4	NP_650904.3	M13	274..1038	CDD:341056	153/813 (19%)
nep-16	NP_001023203.2	GluZincin	254..>725	CDD:472708	116/633 (18%)