DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nep4 and nep-17

DIOPT Version :9

Sequence 1:	NP_650904.3	Gene:	Nep4 / 42449	FlyBaseID:	FBgn0038818	Length:	1040	Species:	Drosophila melanogaster
Sequence 2:	NP_001254395.1	Gene:	nep-17 / 174996	WormBaseID:	WBGene00010070	Length:	1589	Species:	Caenorhabditis elegans

Alignment Length:	877	Identity:	211/877 - (24%)
Similarity:	349/877 - (39%)	Gaps:	245/877 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   258 IRMTQAKTMKRY----------MDNKVDPCVDFYKYACGNWERLHPIPKDKAGFDTFEMLRESLD 312
            |..|....|..|          ::..:|||.|||.|||||:.:       ...|.|..  .::|.
Worm   858 ITSTNVDKMNAYQMAVDYYAKSVNTAIDPCDDFYSYACGNFNQ-------SVSFYTAR--AQNLV 913

  Fly   313 LVLRNLLEK--NTPVHSAAELRKSPVRNTLFKLNEQGEGEGEADQAAELTAERLRRHIVSKRQLL 375
            .:.:.|.:.  .|.::|:..|:|                                     ::||.
Worm   914 YMAQKLEDPTYQTTINSSPALKK-------------------------------------EKQLY 941

  Fly   376 NRVLVRYKRYTNGTKRKRLIETPRERTKEEEAAPPVVLPKDKTKDKSDNEEQLHVPTDFLKPHQD 440
            |..|.                    .|...::...:::.|:..:.|.|:.:.| :..||...:..
Worm   942 NACLT--------------------ATASSQSEDQILISKNYIQTKVDDLKTL-IGQDFTLVNGG 985

  Fly   441 AQL--KAKNL-----YRSCVNSAVLAKRGLEPLHTLIRELGGWPVLESQWSESNFNWQVLAATLR 498
            |..  .||.:     |.|       .::|::   |||.     |::::.|.:::..:|:..
Worm   986 APKLPSAKQIGDALGYLS-------FEQGID---TLIS-----PLVDTYWIDNSKGYQMFI---- 1031

  Fly   499 RYNNDILIVQWVGADIKNSEENIVQFDQTGLGLPTREYFLQPS-----NAKYLQ----AYQRYMA 554
                               ::|.....:|         :.||:     ..|||:    ...||..
Worm  1032 -------------------DQNTAYLSKT---------YYQPAAWKIEKPKYLKMALDVVTRYAR 1068

  Fly   555 EVMHKMGASKADAQRVASELVAFETQLA-------GITAPAEQRLNVTKLYKRMTLDQLQAVVPE 612
            |....:.|..:|   :.|.::.:|..:|       ......::..|:||....:|....
Worm  1069 EQNITLPAGASD---LLSNVLDYEQNIAVKYSTDDNTRRQFQRSWNLTKTSDLVTKYNF------ 1124

  Fly   613 IKWRAYLQSLQDR------------EVLGTEEVVIYAVEYMSKLVTLLDETDPRTVSNYMMWRFV 665
            :.|..||....:.            .|:..:.:..::.:|:        :..|..:.|.:   ||
Worm  1125 MDWMTYLSHAPNAVKAKITDANYQVSVMEVDRLTHFSADYL--------QQSPELLVNLL---FV 1178

  Fly   666 RHRINNVD------DRFDDI-KQSFYHALFGREESPQ-----------RWKVCIAQVNTNMGMAV 712
            |..:.|..      ..|..: .:|.:..|..|:..|.           ....|.:..|..|..|.
Worm  1179 RLLLGNAQYIPSYASAFRGMTDESIFLGLSRRKTIPNHIPPPNFDLEANGPACASVANNLMQFAN 1243

  Fly   713 GSMFVSRYFD-----NNSKRDTLRMTHDLQQAFRDILKTTDWLDDTTKQLAEEKVNAMSLKIGYP 772
            |.:||...:.     .|.::....:..::..:|:.::...||:...|||.|..|...:...|.:|
Worm  1244 GRVFVDYMYPTAQDVTNIRKSAGGIIKNVISSFQGMIDQLDWMAPDTKQKAYAKTVQIQQNIAFP 1308

  Fly   773 DFILNPSELNSKYAGIEIYPEKYFENTLNVL-----------LHTAKTEQAKLHERVNKTNWQTA 826
            |:|.|.:.|.:.|:.:.|.....|.:..:.|           |:.|:|:         :|::...
Worm  1309 DWIKNDTLLGNYYSTLVIADSDNFYDIYDKLIKFNIFVQYNQLNAAQTD---------RTDFLGQ 1364

  Fly   827 PAIVNAYYSRNKNQIMFPAGILQPPFYHRHFPKSLNFGGIGVVIGHELTHGFDDKGRLFDRNGNI 891
            |..|||:|....|.|.||||||.||:::.::|.|:|:||:|:|.||||||||||:|..:...||:
Worm  1365 PGTVNAWYQPELNSITFPAGILVPPYFNPNWPPSINYGGMGLVAGHELTHGFDDQGVQWGPTGNL 1429

  Fly   892 HKWWTDSSIRGFDERARCIIAQYS--------NYTVEEVGIVLNGESTQGENIADNGGLRQAFHA 948
            .:|..|:|:.||...::|:|.:||        ||:..    .:.|..|||||||||||:..||:|
Worm  1430 ARWMDDNSMAGFKNMSQCVINEYSGFCPLNATNYSPN----CVKGPQTQGENIADNGGVHAAFNA 1490

  Fly   949 YQRWLKEHPS-EVSDEILPGL---NMTGPQLFFLNFGQVWCGAMR-PEAIRNKLNTAIHSPGRFR 1008
            |    |.|.| :..|..||..   ..|..||||::|.||||...| .:|:..::....|||..:|
Worm  1491 Y----KTHQSLDGPDPRLPDRLFGQFTHDQLFFMSFAQVWCEVRRTDDALYTQIMVDPHSPSMYR 1551

  Fly  1009 VIGTLSNSVDFAREFNCPLGSPMNPQKKCSVW 1040
            |.||:.|...|...|||||||...|::.|.||
Worm  1552 VYGTIQNFPAFQTAFNCPLGSKSAPEQHCEVW 1583

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nep4	NP_650904.3	M13	274..1038	CDD:189000	204/847 (24%)
nep-17	NP_001254395.1	PepO	108..833	CDD:226118
		M13	112..830	CDD:189000
		PepO	880..1583	CDD:226118	205/853 (24%)
		M13	884..1581	CDD:189000	204/847 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	4.020