DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nep4 and nep-26

DIOPT Version :9

Sequence 1:	NP_650904.3	Gene:	Nep4 / 42449	FlyBaseID:	FBgn0038818	Length:	1040	Species:	Drosophila melanogaster
Sequence 2:	NP_001022540.1	Gene:	nep-26 / 174593	WormBaseID:	WBGene00014171	Length:	807	Species:	Caenorhabditis elegans

Alignment Length:	949	Identity:	211/949 - (22%)
Similarity:	374/949 - (39%)	Gaps:	238/949 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   171 SRTSFLPL----GIPRECLGSGIELDIKPIDEEAYQRQKKRYQDIAPYWLEKIRIRERREAERHA 231
            |.:|..||    ..|.:...:|:.|      ||..|......:|..           :..:.|..
Worm    18 SYSSLNPLLPSEDTPIQSFSNGVSL------EEGKQASSSLLRDTG-----------QPSSSRSK 65

  Fly   232 EEASAE-----------------ISEATAALQSFWNEEGTREGIRMTQAKTMKRYMDNKVDPCVD 279
            |..|:.                 :|.|.|....:.....|.|...||.::.:|| :|..|:||.:
Worm    66 EAISSSSKGCLLLTVLVIFLFVTLSFAIACFLYYQTLPCTSEECVMTASRLLKR-VDQSVEPCDN 129

  Fly   280 FYKYACGNWERLHPIPKDKAGFDTFEMLRESLDLVLRNLLEKNTPVHSAAELRKSPVRNTLFKLN 344
            ||::|||.|                  :.:|::|                   |....|||:
Worm   130 FYQFACGGW------------------INQSVNL-------------------KYDSWNTLY--- 154

  Fly   345 EQGEGEGEADQAAELTAERLRRHIVSKRQLLNRVLVRYKRYTNGTKRKRLIETPRERTKEEEAAP 409
                                                               ||  :||..::
Worm   155 ---------------------------------------------------ET--QRTAHDQ--- 163

  Fly   410 PVVLPKDKTKDKSDNEEQLHVPTDFLKPHQDAQLKAKNLYRSCVNSAVLAKRGLEPLHTLIRELG 474
             :|....|..|.|           :..|....:..|..:|..|:::..|.:.||......:.|||
Worm   164 -IVQAMHKINDGS-----------YPLPTNAGERAAAKMYEQCMDTDTLEQTGLHLWERFVDELG 216

  Fly   475 GW-PVLE--SQWSESNF------------NWQVLAATLRRYNNDILIVQWVGADIK--NSEENIV 522
            || |.|:  :...|.:|            .:::....|..:|..:..:.|.|.::.  ||:|:::
Worm   217 GWMPELKNGALEQEESFEIELDEDEKKRRRFEIEDIILSAFNYSVFPLFWAGVEVNYLNSKEHLI 281

  Fly   523 Q-FDQTGLGLPTREYF----LQP-------SNAKYLQAYQRYMAEVMHKMGASKAD--AQRVASE 573
            . ::|..:.|...:|.    |.|       ......:|.|:...|:...:|....|  .:.:.:.
Worm   282 TIYEQLPILLAPEKYHYNKELTPEMIYGKMEGPPVTRALQQVGEELSAVLGFDSTDEKVRMMIAN 346

  Fly   574 LVAFETQ--LAGITAPAEQRLNVTKLYKRMTLDQLQAVVPEIKWRAYLQSLQDREVLGTEEVVIY 636
            ::..|.|  :||.|...|::    :.|..:.|.:||.:.|.|.|..:|..|....:..:|.:.:.
Worm   347 MIYLEYQITMAGSTFYKEKK----ERYTVVMLRELQEIAPAINWHYFLSRLVGENLSHSEPIALK 407

  Fly   637 A----VEYMSKLVTLLDE--TDPRTVSNYMMWRFVRHRINNVDDRFDD----IKQSFYHALFGRE 691
            .    :..:|.:|..|.:  :....:.||:.|:.:...:.....:..|    :..|.|..
Worm   408 TGTQWIPILSAIVEKLKQSRSGVAVLKNYVKWKTIMFHLAYASPKCRDGLLWMAVSLYSG----- 467

  Fly   692 ESPQRWKVCIAQVNTNMGMAVGSMFVSRYFD-----NNSKRDTLRMTHDLQQAFRDILKTTDWLD 751
            .:.||.:.|:.:::....:::.|  :.|..|     ..:.:....:...:|:.:.:::::::...
Worm   468 AASQRKEFCVLRLSGIFPLSLPS--ILRKIDGIDHTEKNVKAVQNIADRIQEKYEEMVRSSNLFS 530

  Fly   752 D-TTKQLAEEKVNAMSLKIGYPDFILNPSELNSKYAGIEIYPEKYFENTLNVLLHTAKTEQAKLH 815
            | .|::...:|||.|:..||:||.:.:..|:..:  .:.::...::...|. .....|....:|.
Worm   531 DRETRENVIDKVNNMTKFIGFPDAMRSDYEMEKE--AVRLHDTLFWSMVLG-SSSVYKERLQRLR 592

  Fly   816 ERVNKTNW-QTAPAIVNAYYSRNKNQIMFPAGILQPPFYHRHFPKSLNFGGIGVVIGHELTHGFD 879
            ..|:..:| .|.|||....::..:|.:..|...|:.|:...|.....|:.|||.:|||||||.||
Worm   593 LPVDPRSWVDTRPAISVPAHNYERNLVQIPFDSLRLPYADEHQLDFANYAGIGTIIGHELTHAFD 657

  Fly   880 DKGRLFDRNGNIHKWWTDSSIRGFDERARCIIAQYSNYTVEEVGIV----LNGESTQG--ENIAD 938
            .:|:|....||:..||:..|||.|..|.:|.:.||:       |::    :|. :.:|  |||||
Worm   658 GQGKLHGPTGNLGVWWSTDSIREFKAREQCFVKQYA-------GLMDSHDMNA-AKEGLYENIAD 714

  Fly   939 NGGLRQAFHAYQRWLKEHPSEVSDEILPGL-NMTGPQLFFLNFGQVWCGAMRPEAIRNK-LNTAI 1001
            ..||:.   ||:.| |.:.::.|.. :||| ..:..|||||.:.|.||      |:|:| .....
Worm   715 QVGLKV---AYEAW-KSNGNQNSGR-MPGLEKYSQDQLFFLAYTQGWC------ALRSKSYKLQP 768

  Fly  1002 HSPGRFRVIGTLSNSVDFAREFNCPLGSPMNPQKKCSVW 1040
            |...|.|::|:|.||.:||..:.|...|.|||..|||:|
Worm   769 HMEERIRMLGSLQNSPEFASAWKCSSESFMNPPDKCSIW 807

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nep4	NP_650904.3	M13	274..1038	CDD:189000	184/821 (22%)
nep-26	NP_001022540.1	PepO	111..807	CDD:226118	191/837 (23%)
nep-26	NP_001022540.1	M13	124..805	CDD:189000	184/821 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	4.020