Protein Alignment Nep4 and nep-5

DIOPT Version :9

• Sequence 1: NP_650904.3
• Gene: Nep4 / 42449
• FlyBaseID: FBgn0038818
• Length: 1040
• Species: Drosophila melanogaster
• Sequence 2: NP_001364754.1
• Gene: nep-5 / 173933
• WormBaseID: WBGene00017393
• Length: 694
• Species: Caenorhabditis elegans
• Alignment Length: 831
• Identity: 178/831 - (21%)
• Similarity: 282/831 - (33%)
• Gaps: 300/831 - (36%)

  Fly   262 QAKTMKRY-------MDNKVDPCVDFYKYACGNWERLHPIPKDKAGFDTFEMLRESLDLVLRNLL 319
            |.|...:|       ||:.|:||.:|:.:.|..:   :|..||      ||.|     :.|.|:.
 Worm   109 QTKECVKYSAELLELMDSSVNPCENFHHHVCNGF---NPRKKD------FERL-----MKLINIQ 159

  Fly   320 EKNTPVHSAAELRKSPVRNTLFKLNEQGEGEGEADQAAELTAERLRRHIVSKR---QLLNRVLVR 381
            ||  |.|..|   .:.||..|.|. ..|:.| |..|...|::      |:...   .|||
 Worm   160 EK--PDHRKA---VNVVRRMLSKC-AMGKTE-EIHQVGRLSS------IILPGLPFPLLN----- 206

  Fly   382 YKRYTNGTKRKRLIETPRERTKEE-----EAAPPVVL--PKDK----TKDKSDNEEQLHVPTDFL 435
                .:.||....|.|....|...     :....::|  |.|.    .|..||:|..|.|    :
 Worm   207 ----NSWTKPSDPISTSNSSTTYSYPFLTKILAHIILHNPDDAGFVGIKPSSDSEFSLFV----V 263

  Fly   436 KPHQDAQLKAKNLYRSCVNSAVLAKRGLEPLHTLIRELGGWPVLESQWSESNFNWQVLAATLRRY 500
            ||..                                     |||      :||.::.:...|:|
 Worm   264 KPFS-------------------------------------PVL------TNFKFRNMYDILKR- 284

  Fly   501 NNDILIVQWVGADIKNSEENIVQFDQTGLGLPTREYFLQPSNAKYLQAYQRYMAEVMHKMGASKA 565
                           |:.|:...      |:...|:
 Worm   285 ---------------NAPESSTN------GMIDLEF----------------------------- 299

  Fly   566 DAQRVASELVAFETQLAGITAPAE-QRLNVTKLYKRMTLDQLQAVVPEIKWRAYLQS-LQDREVL 628
            |.||..::::..:|:|..|...|: :.:|:|::.::|         |.|.|:..:.| :.:....
 Worm   300 DRQRQLNDVIKLQTKLEKIEFKADPEVVNLTEIQRQM---------PIIDWKRLIDSWIPNGYAH 355

  Fly   629 GTEEVVIYAVEYMSKLVTLLDETDPRTVSNYMM----WRFVRHRINNVDDRFDDIKQSFYH---- 685
            ..|:|..:...|..::..::..|...|:.|::.    ::|:|..:.:      |::.:..|
 Worm   356 LKEKVYGFNTSYYEEINAIISSTPSETIYNFLFLRFSFKFLRTEVAS------DLEDTCLHQLST 414

  Fly   686 ------ALFGREESPQRWKVCIAQVNTNMGMAVGSMFVSRYFDNNSKRDTLRMTHDLQQAFRDIL 744
                  .|:|.|| |:       .:|...|                      |.|.::...:..|
 Worm   415 TIPGKIVLYGSEE-PE-------ALNLLNG----------------------MLHTIKDQLKRSL 449

  Fly   745 KTTDWLDDTTKQLAEEKVNAMSLKIGY--PDFILNPSELNSKYAGIEIYPEKYFENTL-NVLLHT 806
            .|..|:|....:.|::|.|......|:  .|.|   .||..|     |.||..:.:|| ||||
 Worm   450 ATLKWMDSRGIEEAQKKFNKTKTVFGFTGEDLI---DELVGK-----ITPESNYISTLQNVLL-- 504

  Fly   807 AKTEQAKLHERVNKTNWQT-----------APAIVNA--YYSRNKNQIMFPAGILQPPFYHRHFP 858
                            |||           ....:|:  :||..||:|.....:|..||...:.|
 Worm   505 ----------------WQTRNMFKSVAENNVTVFLNSEVFYSVEKNEITISRALLHYPFMSANLP 553

  Fly   859 KSLNFGGIGVVIGHELTHGFDDKGRLFDRNGNIHKWWTDSSIRGFDERARCIIAQYSNYTVEEVG 923
            ...||..|...|..::.|.||::||.:|.:||...||...:.|.|....:|......|.....|.
 Worm   554 NYTNFATIASKILPQMIHIFDERGRFYDSDGNHRNWWNTETERYFQIIVQCFDGMMQNVFGVSVS 618

  Fly   924 IVLNGESTQGENIADNGGLRQAFHAYQRWLKEHPSEVSDEILPGLNMTGPQLFFLNFGQVWCGAM 988
            |..|...:..|..|...|::|:               |||          .|||.:..:..| ..
 Worm   619 IGWNAYDSTKEPYATLPGIQQS---------------SDE----------ALFFYSMVKTMC-TS 657

  Fly   989 RPEAIRNKLNTAIHSPGRFRVIGTLSNSVDFAREFNCPLGSPMNPQKKCSV 1039
            .|:    .:|.|:.|..:|       ||.     |.|..|:.|||..||.:
 Worm   658 DPD----NVNEALASVPQF-------NSA-----FKCNNGTKMNPPTKCKL 692

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nep4	NP_650904.3	M13	274..1038	CDD:189000	172/809 (21%)
nep-5	NP_001364754.1	GluZincin	128..691	CDD:417498	172/809 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.920