DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nep4 and nep-12

DIOPT Version :9

Sequence 1:	NP_650904.3	Gene:	Nep4 / 42449	FlyBaseID:	FBgn0038818	Length:	1040	Species:	Drosophila melanogaster
Sequence 2:	NP_001364537.1	Gene:	nep-12 / 173824	WormBaseID:	WBGene00017842	Length:	832	Species:	Caenorhabditis elegans

Alignment Length:	799	Identity:	221/799 - (27%)
Similarity:	371/799 - (46%)	Gaps:	131/799 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   254 TREGIRMTQAKTMKRYMDNKVDPCVDFYKYACGNWERLHPIPKDKAGFDTFEMLRESLDLVLRNL 318
            |.|.||:  |.:....|:...:||.|||::|||.:.....|.:.:........:::.:|..|:::
Worm   153 TPECIRL--AASYLNNMNRDANPCEDFYEFACGKYATRKVIAEHEKKVTVLSEMKKEMDRHLKDI 215

  Fly   319 LEKNTPVHSAAELRKSPVRNTLFKLNEQGEGEGEADQAAELTAERLRRHIVSKRQLLNRVLVRYK 383
            |||
Worm   216 LEK-------------------------------------------------------------- 218

  Fly   384 RYTNGTKRKRLIETPRERTKEEEAAPPVVLPKDKTKDKSDNEEQLHVPTDFLKPHQDAQLKAKNL 448
                         |.||.|..                                     .:|...:
Worm   219 -------------TSRENTTR-------------------------------------SMKLAQI 233

  Fly   449 Y-RSCVNSAVLAKRGLEPLHTLIRELGGWPVL-ESQWSESNFNWQVLAATLRRYNNDILIVQWVG 511
            | .||::.......|::||.::|..|||||:| .:::...:|.|:|||..|..|..|.:...:|.
Worm   234 YFDSCMDEFSQDDLGVQPLMSMISNLGGWPLLTNARFDSIDFQWEVLAGHLALYGVDGIFRVFVH 298

  Fly   512 ADIKNSEENIVQFDQTGLGLPTREYFLQ-PSNAKYLQAYQRYMAEVMHKMGASKADAQRV----A 571
            :...:|::|::.|....|.|..::::.: ||:..|||.|::|:..::..:|....|...|    .
Worm   299 SSFDDSDKNVLMFSPPKLFLEKKKFYREVPSSNVYLQYYRQYILSLLSLLGVDMEDETGVIEYQV 363

  Fly   572 SELVAFETQLAGITAPAEQRLNVTKLYKRMTLDQLQAVVPEIKWRAYLQSLQDREVLG--TEEVV 634
            .:::.||.::|.:|. .|...|.:.:...:|..:.:....:|.|.|:... :.|..||  .:.:|
Worm   364 DDIIDFERRIANLTR-IELSRNHSSINNMITFGEFKRKYDKINWDAFFNE-EMRGNLGRMPDSLV 426

  Fly   635 IYAVE--YMSKLVTLLDETDPRTVSNYMMWRFVRHRINNVDDRFDDIKQSFYHALFGREESPQRW 697
            |..|:  |...|.:|:......:::|::||..|.:....:..::......|...::|.......|
Worm   427 INVVDVNYFDNLYSLIKSKPLSSINNFLMWCLVSNYDMYLPAKYRKPMLDFRQKMYGVSSDDPLW 491

  Fly   698 KVCIAQVNTNMGMAVGSMFVSRYFDNNSKRDTLRMTHDLQQAFRDILKTTDWLDDTTKQLAEEKV 762
            :||:.:|..|:.|.:.:.:..::|....|.....|..||::|....|...||:|::|::.|..|:
Worm   492 EVCVGEVRENLAMPLSTEYAQKFFTKKDKLVAEDMIRDLKKAMEQTLLNADWIDESTREAALMKL 556

  Fly   763 NAMSLKIGYPDFILNPSELNSKYAGIEIYPEKYFENTLNVLLHTAKTEQAKLHERVNKTNWQTAP 827
            :||..|||:||.:||.:.:...|||:.:...:||:|.:::.....:...:|||...:..:|.:..
Worm   557 DAMGHKIGFPDSLLNETAVLLPYAGVRLTANQYFDNAISLKKAAYRDALSKLHRTPSLIDWASPI 621

  Fly   828 AIVNAYYSRNKNQIMFPAGILQPPFYHRHFPKSLNFGGIGVVIGHELTHGFDDKGRLFDRNGNIH 892
            ..|:|::....|:|:|||||||.|.:....|...|:|.||:.||||:|||:||.|..:|..||:.
Worm   622 IAVDAFHYFTGNEIIFPAGILQFPMFVPDAPAFSNYGAIGMGIGHEITHGYDDLGAQYDDKGNLR 686

  Fly   893 KWWTDSSIRGFDERARCIIAQYSNYTVEEVGIVLNGESTQGENIADNGGLRQAFHAYQRWLKEHP 957
            .||...::..|.::.:|.:|||.:....:.|..::|:.|.|||||||||||.||.|||   ....
Worm   687 GWWHTETMTTFQKKKQCFVAQYGSKIEPQTGRKVDGKMTIGENIADNGGLRVAFQAYQ---LRSD 748

  Fly   958 SEVSDEILPGLNMTGP-QLFFLNFGQVWCGAMRPEAIRNKLNTAIHSPGRFRVIGTLSNSVDFAR 1021
            .|.....||||....| |||||.:...||.|::|.||.:.::|.:||.|.|||...|.|...|::
Worm   749 REKETRRLPGLTDFSPNQLFFLAYANTWCEALKPSAIDHIMDTDVHSLGMFRVNVPLQNLPAFSK 813

  Fly  1022 EFNCPLGSPMNPQKKCSVW 1040
            ||:||:||||||.:||.:|
Worm   814 EFDCPIGSPMNPFEKCRIW 832

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nep4	NP_650904.3	M13	274..1038	CDD:189000	213/775 (27%)
nep-12	NP_001364537.1	M13	171..830	CDD:341056	213/775 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG61902
OrthoDB	1	1.010	-	-		D157132at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.930