DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nep4 and nep-3

DIOPT Version :9

Sequence 1:	NP_650904.3	Gene:	Nep4 / 42449	FlyBaseID:	FBgn0038818	Length:	1040	Species:	Drosophila melanogaster
Sequence 2:	NP_494679.2	Gene:	nep-3 / 173730	WormBaseID:	WBGene00016778	Length:	634	Species:	Caenorhabditis elegans

Alignment Length:	810	Identity:	175/810 - (21%)
Similarity:	286/810 - (35%)	Gaps:	272/810 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   260 MTQAKTMKRYMDNKVDPCVDFYKYACGNWERLHPIPKDKAGFDTFEMLRESLDLVLRNLLEKNTP 324
            :|....:..:.|..||||.:||:.|||
Worm    68 ITLVHQLLNFQDPSVDPCENFYQAACG-------------------------------------- 94

  Fly   325 VHSAAELRKSPVRNTLFKLNEQGEGEGEADQAAELTAERLRRHIVSKRQLLNRVLVRYKRYTNGT 389
                             |.||....:|..      ||:        |:|::
Worm    95 -----------------KYNEHNVIDGSR------TAQ--------KQQIV-------------- 114

  Fly   390 KRKRLIETPRERTKEEEAAPPVVLPKDKTKDKSDNEEQLHVPTDFLKPHQDAQLKAKN----LYR 450
              ||||.                                    |||..:|.:..|::|    ||.
Worm   115 --KRLIR------------------------------------DFLHKNQSSTSKSENSMKLLYE 141

  Fly   451 SCVNSAVLAKRG----LEPLHTLIRELGGWPVLESQWSESNFNWQVLAATLRR--YNN----DIL 505
            .|..:..:...|    |:.:...|:::|.||||:..|....||...:..:|.|  .:|    :|:
Worm   142 KCKEAKTIKVLGNQNLLQEIFMNIQKIGSWPVLDENWDGKKFNLNEMLLSLIRLGVSNFGFFEII 206

  Fly   506 IVQWVGADIKNSEENIVQFDQTGLGLPTREYFLQPSNAKYLQAYQRYMAEVMHKMGASKADAQRV 570
            |......:||.:.           ..||||                .:::::.|:....
Worm   207 ISSDAFVEIKPAR-----------NFPTRE----------------NLSDIISKVFLGN------ 238

  Fly   571 ASELVAFETQLAGITAPAEQRLNVTKLYKRMTLDQLQAVVPEIKWRAYLQSLQDREVLGTEEVVI 635
                 .|:..:..|                           |...|.| ::|| ||
Worm   239 -----GFQPNITAI---------------------------ENDLREY-ENLQ-RE--------- 260

  Fly   636 YAVEYMSKLVTLLDETDPRTVSNYMMWRFVRHRINNVDDRFDDIKQSFYHALFGREESPQRWKVC 700
                 :..|..|:..|..|::.||:::.:::                  ..:...:..|:  :.|
Worm   261 -----LKSLERLIQTTPNRSLVNYLIFNYLK------------------SVMLEYKRLPE--EQC 300

  Fly   701 IAQVNTNMGMAVGSMFVSRYFDNNSKRDTLRMTHDLQQAFRDILKTTDWLDDTTKQLAEEKVNAM 765
            ...|...:..|...:||..:.|..:::....|..|::..|.|:::.:.||::.:|::|.:||..:
Worm   301 EGVVIDFLPRASTRVFVQNFLDKENRKYVAGMIEDVKMGFIDMIQESTWLNEESKKVAVQKVKNI 365

  Fly   766 SLKIGYPDFILNPSELNSKYAGIEIYPEKYFENTLNVLLHTAKTEQAKLHERVNK-TNWQTAPAI 829
            ...||||||...|..|:..:..:.|      |.|.:  .||       :..::.| ||.|....:
Worm   366 KSMIGYPDFFEPPGTLDRSFKDLNI------EQTDS--YHT-------IVRKIQKFTNEQCMEFV 415

  Fly   830 --------------VNAYYSRNKNQIMFPAGILQPPFYHRHFPKSLNFGGIGVVIGHELTHGFDD 880
                          .||:| :|.|.:...|.:|..|.:...||:.:|...||.|:.||:.|.||.
Worm   416 ASEIPLDPRQPILHANAFY-QNTNFLAILAPVLDDPIFDTTFPRYVNLAVIGNVLAHEIGHAFDH 479

  Fly   881 KGRLFDRNGNIHKWWTDSSIRGFDERARCIIAQYSNYTVEEVGIVLNGESTQGENIADNGGLRQA 945
            .|..:|..|....|.|......:.:|.||::.|:..|...:.|..|||..|..|..||..|:..|
Worm   480 TGINYDDAGQQRIWLTPEDSEEYGKRLRCLLRQHDEYDDPDFGRNLNGSKTLHEISADRFGVEAA 544

  Fly   946 FHAYQRWLKEHPSEVSDEILPGLNMTGPQLFFLNFGQVWCGAMRPEAIRNKLNTAIHSPGRFRVI 1010
            :..:::....:.|    ||:...|....||:|.....:||.......::..|... |....|||.
Worm   545 WRTFKKLDLSNES----EIVGFQNFNIDQLYFRTAALIWCRQRDTTDLQYALQRE-HPTNNFRVN 604

  Fly  1011 GTLSNSVDFAREFNCPLGSPMNPQKKCSVW 1040
            |..:|...||..|||||||||||:|||.::
Worm   605 GIYANMPQFAETFNCPLGSPMNPKKKCDLF 634

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nep4	NP_650904.3	M13	274..1038	CDD:189000	172/792 (22%)
nep-3	NP_494679.2	M13	82..631	CDD:189000	171/791 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160161776
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.850