Protein Alignment Nep4 and nep-11

DIOPT Version :10

• Sequence 1: NP_650904.3
• Gene: Nep4 / 42449
• FlyBaseID: FBgn0038818
• Length: 1040
• Species: Drosophila melanogaster
• Sequence 2: NP_494538.1
• Gene: nep-11 / 173685
• WormBaseID: WBGene00017557
• Length: 848
• Species: Caenorhabditis elegans
• Alignment Length: 1063
• Identity: 312/1063 - (29%)
• Similarity: 482/1063 - (45%)
• Gaps: 253/1063 - (23%)

  Fly     2 SRHSQLKLAMPSVHGAPATAPGSP-MNAKAR----SVKLGLGVNQRTGRVQWCPGLTCCKMLLLL 61
            |..||::|...|.:....|..||| .||.||    || :.:...:..|..:|....|..:. |||
 Worm    15 SNESQMQLITISENSDIPTPSGSPCFNAPARDEAPSV-IFIPGKKFQGTFRWWKSRTTMEK-LLL 77

  Fly    62 PVVMLPLTLVLILIMRLDGMLAALQLNEQRMRDLRNSHSEVPVYMEDYEALLPEGSTYNDLINEE 126
            ||::|...|..:|       ||.:...::|:..::..|           |...|.:.:.|
 Worm    78 PVLLLFCLLTAVL-------LAVIINTDKRIEAMKTDH-----------ATQTEHAGFGD----- 119

  Fly   127 FILPASKRTQLQILAAERARRCQPYRYGNGESMELEERNTLMKDSRTSFLPLGIPRECLGSGIEL 191
               |....|:    .||..|                             :|..:|        |.
 Worm   120 ---PTENPTK----TAEDPR-----------------------------VPPIVP--------EA 140

  Fly   192 DIKPIDEEAYQRQKKRYQDIAPYWLEKIRIRERREAERHAEEASAEISEATAALQSFWNEEGTRE 256
            ...|..|.....:|.:..::.                    .....:..||..|.:
 Worm   141 PTSPEPEVTTSTEKPKEPEVC--------------------STPGCVRAATHFLNA--------- 176

  Fly   257 GIRMTQAKTMKRYMDNKVDPCVDFYKYACGNWERLHPIPKDKAGFDTFEMLRESLDLVLRNLLEK 321
                         |:..||||.||:::|||.|...||||.|..||.||...||.:...||.|||
 Worm   177 -------------MNTSVDPCDDFFEFACGQWNDQHPIPDDMYGFGTFAYAREQVRQQLRVLLE- 227

  Fly   322 NTPVHSAAELRKSPVRNTLFKLNEQGEGEGEADQAAELTAERLRRHIVSKRQLLNRVLVRYKRYT 386
                                                        :.:|::.:.:|
 Worm   228 --------------------------------------------QEVVTESESIN---------- 238

  Fly   387 NGTKRKRLIETPRERTKEEEAAPPVVLPKDKTKDKSDNEEQLHVPTDFLKPHQDAQLKAKNLYRS 451
                                                                     .|:..|||
 Worm   239 ---------------------------------------------------------MARATYRS 246

  Fly   452 CVNSAVLAKRGLEPLHTLIRELGGWPVLESQWSESNFNWQVLAATLRR-YNNDILIVQWVGADIK 515
            |:|...|.:....||...:.|||.||:|:..|.::.||:..|....|| |..|:....::.||.|
 Worm   247 CMNKTQLDELMTGPLFETLTELGEWPLLQENWDKTKFNFTSLLVNSRRDYGVDVFFQLYIYADSK 311

  Fly   516 NSEENIVQFDQT--GLGLPTREYFLQPS-NAKYLQAYQRYMAEVMHKMGASKADAQRVASE---- 573
            |:..|.:..||:  .||..||:|:|..: .:.::.||::|:.::.|.:   |.|.....||
 Worm   312 NTSRNTLFIDQSTLALGRGTRDYYLNTTLFSSHMTAYRKYLRQIAHLL---KTDGNLTRSESEMN 373

  Fly   574 -----LVAFETQLAGITAPAEQRLNVTKLYKRMTLDQLQAVVPEIKWRAYLQSLQDREVL----G 629
                 ::.||.:||.|....::|.|.|:||.:..:..|..::|::.|..:.||:...::.    .
 Worm   374 ADIEKIIDFEIELAKIIVAEDERRNNTRLYNKRQIQDLYNLLPQVDWVPFFQSIAPSDLTHLFHN 438

  Fly   630 TEEVVIYAVEYMSKLVTLLDETDPRTVSNYMMWRFVRHRINNVDDRFDDIKQSFYHALFGREESP 694
            ..|::|..:||:..:..|:::||...::||::||.|:..:..:|:||:||||.|...:.|:::||
 Worm   439 ETEIIICEIEYLQHVSELIEKTDVGLLTNYVLWRVVQSNVRYLDERFEDIKQDFLKVMTGQQQSP 503

  Fly   695 QRWKVCIAQVNTNMGMAVGSMFVSRYFDNNSKRDTLRMTHDLQQAFRDILKTTDWLDDTTKQLAE 759
            .|||.|....:|.:.:|.|:::|..:|..:.|.:.|||...|:.:|.|:::..||:|:.||.:|.
 Worm   504 PRWKDCAQVPSTVLPLAAGAIYVQAHFQESDKHEALRMIMHLRNSFADLVRQNDWMDEETKAVAI 568

  Fly   760 EKVNAMSLKIGYPDFILNPSELNSKYAGIEIY-PEKYFENTLNVLLHTAKTEQAKLHERVNKTNW 823
            ||.|:|...|||||...:..:|:.:|.|:.|. .:.|:......::.....|..||.:..:|..:
 Worm   569 EKANSMINNIGYPDVTNDLPKLDKQYLGLSISDSDTYYYIMKKSVVWMQSREFQKLTKPFDKHEF 633

  Fly   824 QTAPAIVNAYYSRNKNQIMFPAGILQPPFYHRHFPKSLNFGGIGVVIGHELTHGFDDKGRLFDRN 888
            ..:||:|||:||..||.|.||||||||||:...|||::|:|.||.|||||:||||||:|..:|::
 Worm   634 DISPAVVNAFYSPEKNAITFPAGILQPPFFSGTFPKAVNYGAIGAVIGHEITHGFDDQGSQYDKD 698

  Fly   889 GNIHKWWTDSSIRGFDERARCIIAQYSNYTVEEVGIVLNGESTQGENIADNGGLRQAFHAYQRWL 953
            ||:|.||::||:..||.|.|||:.||.||||.:....:||:.|||||||||||:::||.|||:::
 Worm   699 GNLHNWWSESSLNSFDTRRRCIVEQYGNYTVPKTNFRVNGKLTQGENIADNGGVKEAFQAYQKYV 763

  Fly   954 KEHPSEVSDEILPGLNM-TGPQLFFLNFGQVWCGAMRPEAIRNKLNTAIHSPGRFRVIGTLSNSV 1017
            .|:..|..   ||||.. |..|:||:::...|||..:..|...::.|..|||..|||||.|||..
 Worm   764 TENGEEPR---LPGLQQYTNEQIFFVSYAHFWCGKKKEAAAMQQVLTDEHSPEVFRVIGVLSNMQ 825

  Fly  1018 DFAREFNCPLGSPMNPQKKCSVW 1040
            .||..:.||..:|:||..||.||
 Worm   826 AFADVYKCPRNAPVNPDHKCIVW 848

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nep4	NP_650904.3	M13	274..1038	CDD:341056	261/782 (33%)
nep-11	NP_494538.1	M13	181..845	CDD:341056	260/781 (33%)