DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nep4 and nep-9

DIOPT Version :9

Sequence 1:	NP_650904.3	Gene:	Nep4 / 42449	FlyBaseID:	FBgn0038818	Length:	1040	Species:	Drosophila melanogaster
Sequence 2:	NP_494531.2	Gene:	nep-9 / 173683	WormBaseID:	WBGene00017554	Length:	700	Species:	Caenorhabditis elegans

Alignment Length:	844	Identity:	158/844 - (18%)
Similarity:	283/844 - (33%)	Gaps:	282/844 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   263 AKTMKRYMDNKVDPCVDFYKYACGNWERLHPIPKDKAGFDTFEMLRESLDLVLRNLLEKNTPVHS 327
            |:.:|.|.|.....|.||||..|.|:       ||....|
Worm    73 AQELKAYSDTATKSCEDFYKATCENY-------KDHQALD------------------------- 105

  Fly   328 AAELRKSPVRNTLFKLNEQGEGEGEADQAAELTAERLRRHIVSKRQLLNRVLVRYKRYTNGTKRK 392
                                                 |.....||:.:|:::..:.:....|
Worm   106 -------------------------------------RHRDCKKRKAVNKLVRGFLQRDEST--- 130

  Fly   393 RLIETPRERTKEEEAAPPVVLPKDKTKDKSDNEEQLHVPTDFLKPHQDAQLKAKNLYRSCVNSAV 457
                    .|.|.|:|..::..|.         ::|...|.:|...:|
Worm   131 --------FTSESESAIKLIFGKC---------DELSRNTSYLDIFKD----------------- 161

  Fly   458 LAKRGLEPLHTLIRELGGWPVLESQWSESNFNW-QVLAATLRRYNNDILIVQ------------- 508
                        |:::|.|||||..|.:|.||. .|:|..::..:.|..:.:
Worm   162 ------------IKKIGSWPVLEHNWKDSMFNLDDVIAKLVKLGSTDFGLFKLELRKLAFGHFAV 214

  Fly   509 WVGADIKNSEENIVQFDQTGLGL-------------------------PTREYFLQPSNAKYLQA 548
            :|.:   ..|:||.|.::|.||:                         ..:|::.:.:   |::
Worm   215 FVSS---KQEQNIHQLEKTILGILKANGIQQDRKELSDDLKDYSDFKNHLKEFYQEET---YIE- 272

  Fly   549 YQRYMAEVMHKMGASKADAQRVASELVAFETQLAGITAPAEQRLNVTKLYKRMTLDQLQAVVPEI 613
            |:.|...::..:|.|            :..||:|               .|...||....|
Worm   273 YRLYAGSIVENLGIS------------SLTTQMA---------------LKSTGLDVFNHV---- 306

  Fly   614 KWRAYLQSLQDREVLGTEEVVIYAVEYMSKLVTLLDETDPRTVSNYMMWRFVRHRINNVDDRFDD 678
                      ::..|.|...:.:..|  :.|..::.:|..||::|::::.|:.....::.:....
Worm   307 ----------NQRTLITNSSLFFGEE--NNLGMIIQKTPKRTLANFLIFHFIDVMTTDLANATKA 359

  Fly   679 IKQSFYHALFGREESPQRWKVCIAQVNTNMGMAVGSMFVSRYFDN-NSKRDTLRMTHDLQQAFRD 742
            .|::....|      |:      |.:..          :||.|.| :::.|.::|..||:
Worm   360 CKETLIDLL------PR------ASIQV----------LSRNFVNEDAQDDMVKMAQDLK----- 397

  Fly   743 ILKTTDWLDDT--------------TKQLAEEKVNAMSLKIGYPDFILNPSELNSKYAGIEIYPE 793
             .|.|:.:|::              .|:|. :||.|:.:...||..:     |:..:..:.:.|.
Worm   398 -TKITEMIDNSPFFTKFHLVFDAEEQKKLI-QKVKAIGIVTEYPQEV-----LDRDFERLNLTPS 455

  Fly   794 KYFENTLNVLLHTAKTEQAKLH-----ERVNKTNWQTAPAIVNAYYSRNKNQIMFPAGILQPPFY 853
            .....|:. .|...::||...|     :..:...|.      :|:|.:..|.:...|.|:..|::
Worm   456 DSIYRTIQ-KLRRLRSEQLIEHLGGDLDPTDTRVWG------SAHYDQTTNNLTIFAPIIDGPYF 513

  Fly   854 HRHFPKSLNFGGIGVVIGHELTHGFDDKGRLFDRNGNIHKWWTDSSIRGFDERARCIIAQYSN-- 916
            ...:|..:|...:|.::|.||....|......|..|....|....|::.|||..:|...:|..
Worm   514 DTSYPNYVNQFLMGFILGRELGRSLDSVRIRKDEKGQTENWLKPESLKRFDEHLKCWAEKYDKSA 578

  Fly   917 --YTVEEVGI-VLNGESTQGENIADNGGLRQAFHAYQRWLKEHPSEVSDEILPGLNMTGPQLFFL 978
              ...|..|| .:.|...|.|..||..|...::.|:.:.     ...::|:|....:...:..|.
Worm   579 DPLKSESKGIRQIEGRYIQNEMFADFIGHEASWRAFMKL-----DVKNEEVLETFKVIKLRRMFF 638

  Fly   979 NFGQVW-CGAMRPEAIRNKLN-TAIHSPGRFRVIGTLSNSVDFAREFNCPLGSPMNPQKKCSVW 1040
            |...:: |  ..|....:.|: ...|....|||.|...|...||..|.|.....||||.|||::
Worm   639 NVQALYFC--RPPSGSTDWLSYQEHHQHYSFRVNGAFKNMPQFALAFECASDDDMNPQNKCSMF 700

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nep4	NP_650904.3	M13	274..1038	CDD:189000	152/829 (18%)
nep-9	NP_494531.2	M13	87..698	CDD:189000	152/826 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160161780
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.840