Protein Alignment Nep4 and Ecel1

DIOPT Version :10

• Sequence 1: NP_650904.3
• Gene: Nep4 / 42449
• FlyBaseID: FBgn0038818
• Length: 1040
• Species: Drosophila melanogaster
• Sequence 2: NP_067281.2
• Gene: Ecel1 / 13599
• MGIID: 1343461
• Length: 775
• Species: Mus musculus
• Alignment Length: 785
• Identity: 250/785 - (31%)
• Similarity: 384/785 - (48%)
• Gaps: 126/785 - (16%)

  Fly   263 AKTMKRYMDNKVDPCVDFYKYACGNWERLHPIPKDKAGFDTFEMLRESLDLVLRNLLEKNTPVHS 327
            |:.:...:|..:|||.|||.:|||.|.|.|.||.||..:
Mouse   110 ARFLSANLDASIDPCQDFYSFACGGWLRRHAIPDDKLTY-------------------------- 148

  Fly   328 AAELRKSPVRNTLFKLNEQGEGEGEADQAAELTAERLRRHIVSKRQLLNRVLVRYKRYTNGTKRK 392
                      .|:..:.||.|             |||||.:.              |.|.|
Mouse   149 ----------GTIAAIGEQNE-------------ERLRRLLA--------------RPTGG---- 172

  Fly   393 RLIETPRERTKEEEAAPPVVLPKDKTKDKSDNEEQLHVPTDFLKPHQDAQLKAKNLYRSCVNSAV 457
                                                        |...||.|.:..:|||::...
Mouse   173 --------------------------------------------PGGAAQRKVRAFFRSCLDMRE 193

  Fly   458 LAKRGLEPLHTLIRELGGWPVLESQWSESNFNW---QVLAATLRRYNNDILIVQWVGADIKNSEE 519
            :.:.|..|:..:|.:.|||.:..:........|   ::|......|:...|....|..|.:||..
Mouse   194 IERLGPRPMLEVIEDCGGWDLGGAADRPGAARWDLNRLLYKAQGVYSAAALFSLTVSLDDRNSSR 258

  Fly   520 NIVQFDQTGLGLPTREYFL--QPSNAKYLQAYQRYMAEVMHKMGASKADAQRVASELVAFETQLA 582
            .:::.||.||.||.|..:|  ...:.|.|.||:.:|..::..:||...:.:  |.|::..|.:||
Mouse   259 YVIRIDQDGLTLPERTLYLAQDEESEKILAAYRVFMQRLLRLLGADAVEQK--AQEILQLEQRLA 321

  Fly   583 GITAPA--EQRLNVTKLYKRMTLDQLQAVVPEIKWRAYLQSLQDREVLGTEEVVIYAVEYMSKLV 645
            .|:...  :.|.:|:..|.::||.|||.::|.::|:..|..:...:....||||:.|.:||.::.
Mouse   322 NISVSEYDDLRRDVSSAYNKVTLGQLQKIIPHLQWKWLLDQIFQEDFSEEEEVVLLATDYMQQVS 386

  Fly   646 TLLDETDPRTVSNYMMWRFVRHRINNVDDRFDDIKQSFYHALFGREESPQRWKVCIAQVNTNMGM 710
            .|:..|..|.:.||::||.|.....::...|.:........:.|.::..:..:||:.|.|.:.||
Mouse   387 QLIRSTPRRILHNYLVWRVVVVLSEHLSSPFREALHELAKEMEGNDKPQELARVCLGQANRHFGM 451

  Fly   711 AVGSMFVSRYFDNNSKRDTLRMTHDLQQAFRDILKTTDWLDDTTKQLAEEKVNAMSLKIGYPDFI 775
            |:|::||..:|...||....::..|::......|:..||:|..||..|..|:..|.:.:|||||:
Mouse   452 ALGALFVHEHFSAASKAKVQQLVEDIKYILGQRLEELDWMDAQTKAAARAKLQYMMVMVGYPDFL 516

  Fly   776 LNPSELNSKYAGIEIYPEKYFENTLNVLLHTAKTEQAKLHERVNKTNWQTAPAIVNAYYSRNKNQ 840
            |.|..::.:|. .|::.:.||:|.||.:..:.:....|:.:.|:|::|...|..:||||..||||
Mouse   517 LKPEAVDKEYE-FEVHEKTYFKNILNSIRFSIQLSVKKIRQEVDKSSWLLPPQALNAYYLPNKNQ 580

  Fly   841 IMFPAGILQPPFYHRHFPKSLNFGGIGVVIGHELTHGFDDKGRLFDRNGNIHKWWTDSSIRGFDE 905
            ::||||||||..|...||:|||:||||.:||||||||:||.|..:||:||:..|||::|...|..
Mouse   581 MVFPAGILQPTLYDPDFPQSLNYGGIGTIIGHELTHGYDDWGGQYDRSGNLLHWWTETSYSHFLR 645

  Fly   906 RARCIIAQYSNYTVEEVGIVLNGESTQGENIADNGGLRQAFHAYQRWLKEHPSEVSDEILPGLNM 970
            :|.||:..|.|:||....:  ||:.|.||||||.|||:.|::|||:|::||..|   ..|..|..
Mouse   646 KAECIVRLYDNFTVYNQRV--NGKHTLGENIADMGGLKLAYYAYQKWVREHGPE---HPLHRLKY 705

  Fly   971 TGPQLFFLNFGQVWCGAMRPEAIRNKLNTAIHSPGRFRVIGTLSNSVDFAREFNCPLGSPMNPQK 1035
            |..||||:.|.|.||...|.::|..::.|..|:|..:||:|::|...:|.|.|:||..|||||..
Mouse   706 THNQLFFIAFAQNWCIKRRSQSIYLQVLTDKHAPEHYRVLGSVSQFEEFGRAFHCPKDSPMNPVH 770

  Fly  1036 KCSVW 1040
            |||||
Mouse   771 KCSVW 775

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nep4	NP_650904.3	M13	274..1038	CDD:341056	244/770 (32%)
Ecel1	NP_067281.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	30..52
		M13	121..773	CDD:341056	244/770 (32%)