Protein Alignment Nep4 and Nep4

DIOPT Version :10

• Sequence 1: NP_650904.3
• Gene: Nep4 / 42449
• FlyBaseID: FBgn0038818
• Length: 1040
• Species: Drosophila melanogaster
• Sequence 2: XP_061501026.1
• Gene: Nep4 / 1273777
• VectorBaseID: AGAMI1_013990
• Length: 1007
• Species: Anopheles gambiae
• Alignment Length: 1078
• Identity: 524/1078 - (48%)
• Similarity: 681/1078 - (63%)
• Gaps: 132/1078 - (12%)

  Fly     2 SRHSQLKLAMPSVHGAPATAPGSPMNAKARSVKLG---LGVNQRTGRVQWCPGLTCCKMLLLLPV 63
            ::|.:..|   ||..|.:.||....:....|...|   ||:::||||:|||||....|.|.::|.
Mosquito    23 NKHDKGSL---SVTAASSPAPNCGEDGGGGSGGGGGCTLGIDERTGRLQWCPGYRFVKFLFVIPA 84

  Fly    64 VMLPLTLVLILIMRL----------DGMLAALQLNEQRMR--DLRNSHSEVPVYMEDYEALLPEG 116
            .|||:.|:.:|:.|.          ||.    ||.|....  ||.........|.|::.
Mosquito    85 AMLPIGLLFLLLSRFQVVGSVSLAGDGH----QLTEPSTTTDDLEGCGEFGYYYTEEHL------ 139

  Fly   117 STYNDLINEEFILPASKRTQLQILAAERARRCQPY-RYGNGESMELEERNTLMKDSRTSFLPLG- 179
            :|.|:.:.||  :..:::|     |.:..|||:|. ..|..||::.::|..|....||||:|..
Mosquito   140 TTNNNHLTEE--IDWAEQT-----ADDVERRCEPIPEKGPSESLDTDDRGLLRGIVRTSFIPSER 197

  Fly   180 --IPRECLGSGIELDIKPIDEEAYQRQKKRYQDIAPYWLEKIRIRERREAERHAEEASAEISEAT 242
              :|.:|||           |:|                      :...|...|.|.|.::....
Mosquito   198 RVLPADCLG-----------EQA----------------------QPSTATEKAVERSEQLPRVR 229

  Fly   243 AALQSFWNEEGTREGIRMTQAKTMKRYMDNKVDPCVDFYKYACGNWERLHPIPKDKAGFDTFEML 307
            .::....::..:.|.:|..|...||:|||...|||.|||:||||||:|::|||||||..||||:|
Mosquito   230 RSVGWMNDDRSSPESVRAAQVAIMKQYMDPDADPCDDFYQYACGNWDRVNPIPKDKAALDTFELL 294

  Fly   308 RESLDLVLRNLLEKNTPVHSAAELRKSPVRNTLFKLNEQGEGEGEADQAAELTAE---------- 362
            ||||||||:.||.:..|   |..|   .|.|.|..:..|.:|..::.......|.
Mosquito   295 RESLDLVLKQLLLEGEP---AGLL---DVENALSTVRSQPDGTKKSTSTTTTAASAGWPTTTVTG 353

  Fly   363 ---RLRRHIVSKR-QLLNRVLVRYKRYTNGTKRKRLI---ETPRERTKEEEAAPPVVLPKDKTKD 420
               :.:.|.|.|| :..||     .|.....:.|.:|   :..|.|.|.|
Mosquito   354 GPAQQQLHRVRKRGRAENR-----NRSGRAVQNKLIIRSAQVKRVRRKRE--------------- 398

  Fly   421 KSDNEEQLHVPTDFLKPHQDAQLKAKNLYRSCVNSAVLAKRGLEPLHTLIRELGGWPVLESQ-WS 484
                          |..:.||::||::|:.||:|..::.:||||||.||:..||||||||.. |.
Mosquito   399 --------------LLINDDAEMKARHLFVSCMNYELIERRGLEPLRTLLHSLGGWPVLEPHTWD 449

  Fly   485 ESNFNWQVLAATLRRYNNDILIVQWVGADIKNSEENIVQFDQTGLGLPTREYFLQPSNAKYLQAY 549
            ||:|:|..|.|.|||||||:|||:|||.|||||:|||||||||.||||||:|:|||.|.|||:||
Mosquito   450 ESSFDWLNLTAALRRYNNDVLIVEWVGPDIKNSDENIVQFDQTSLGLPTRDYYLQPGNRKYLEAY 514

  Fly   550 QRYMAEVMHKMGASKADAQRVASELVAFETQLAGITAPAEQRLNVTKLYKRMTLDQLQAVVPEIK 614
            :::|.||:..:......|::...|::.||||||.||:..|:|.||:.||:::.|||||..||:|.
Mosquito   515 RQFMLEVIGLLDVPADTARQATDEMIEFETQLANITSTPEERNNVSTLYRKLMLDQLQEEVPQIN 579

  Fly   615 WRAYLQSLQDREVLGTEEVVIYAVEYMSKLVTLLDETDPRTVSNYMMWRFVRHRINNVDDRFDDI 679
            |..||..:.:|.|.|:..||::|:.||..||.|:|:|:||.|:||::||||||||||:||||...
Mosquito   580 WTHYLTIVTERPVNGSSFVVMFAMSYMRDLVELIDQTEPRIVANYLLWRFVRHRINNLDDRFLGA 644

  Fly   680 KQSFYHALFGREESPQRWKVCIAQVNTNMGMAVGSMFVSRYFDNNSKRDTLRMTHDLQQAFRDIL 744
            ||.|.:||||||.:|.|||.|:.|||.|||||||:|||.||||.|||||||.|||:||.|||:||
Mosquito   645 KQRFSNALFGRERNPPRWKNCVTQVNANMGMAVGAMFVRRYFDENSKRDTLTMTHELQDAFREIL 709

  Fly   745 KTTDWLDDTTKQLAEEKVNAMSLKIGYPDFILNPSELNSKYAGIEIYPEKYFENTLNVLLHTAKT 809
            ..|.|:|..|:||||:|||||||:||||||||:|.:|:::||.:||:|::|||||||||.|..:|
Mosquito   710 GRTGWIDMATRQLAEQKVNAMSLRIGYPDFILDPEQLSARYATLEIHPDRYFENTLNVLSHIRRT 774

  Fly   810 EQAKLHERVNKTNWQTAPAIVNAYYSRNKNQIMFPAGILQPPFYHRHFPKSLNFGGIGVVIGHEL 874
            :|.||.:.||||.|.||||:|||||||||||||||||||||||||||.||::|:|||||||||||
Mosquito   775 DQEKLGQPVNKTAWHTAPAVVNAYYSRNKNQIMFPAGILQPPFYHRHLPKAINYGGIGVVIGHEL 839

  Fly   875 THGFDDKGRLFDRNGNIHKWWTDSSIRGFDERARCIIAQYSNYTVEEVGIVLNGESTQGENIADN 939
            |||||||||||||:||:::||:|.:|..|.|||.|::.||..|.:.||.:.|:||:|||||||||
Mosquito   840 THGFDDKGRLFDRDGNLYRWWSDRAIEEFHERAACLVEQYGRYRIAEVDVQLDGENTQGENIADN 904

  Fly   940 GGLRQAFHAYQRWLKEHPSE--VSDEILPGLNMTGPQLFFLNFGQVWCGAMRPEAIRNKLNTAIH 1002
            ||::|||.||.:||......  :..|.|||||:|..|||||||.|:|||||||||.||||.||:|
Mosquito   905 GGIKQAFLAYSKWLAAQTDRRVLEAETLPGLNVTRTQLFFLNFAQIWCGAMRPEATRNKLKTAVH 969

  Fly  1003 SPGRFRVIGTLSNSVDFAREFNCPLGSPMNPQKKCSVW 1040
            ||||||||||||||.|||||::||:||.|||..|||||
Mosquito   970 SPGRFRVIGTLSNSEDFAREYHCPVGSTMNPPGKCSVW 1007

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nep4	NP_650904.3	M13	274..1038	CDD:341056	444/783 (57%)
Nep4	XP_061501026.1	None