DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nep4 and EEF1AKMT4-ECE2

DIOPT Version :9

Sequence 1:	NP_650904.3	Gene:	Nep4 / 42449	FlyBaseID:	FBgn0038818	Length:	1040	Species:	Drosophila melanogaster
Sequence 2:	NP_055508.3	Gene:	EEF1AKMT4-ECE2 / 110599583	HGNCID:	53615	Length:	883	Species:	Homo sapiens

Alignment Length:	774	Identity:	274/774 - (35%)
Similarity:	408/774 - (52%)	Gaps:	121/774 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   270 MDNKVDPCVDFYKYACGNWERLHPIPKDKAGFDTFEMLRESLDLVLRNLLEKNTPVHSAAELRKS 334
            :|..|.||.|||:::||.|.|.:|:|..::.::||..|.:....:|::||| ||..:|::|
Human   228 LDRGVSPCEDFYQFSCGGWIRRNPLPDGRSRWNTFNSLWDQNQAILKHLLE-NTTFNSSSE---- 287

  Fly   335 PVRNTLFKLNEQGEGEGEADQAAELTAERLRRHIVSKRQLLNRVLVRYKRYTNGTKRKRLIETPR 399

Human   288 ----------------------------------------------------------------- 287

  Fly   400 ERTKEEEAAPPVVLPKDKTKDKSDNEEQLHVPTDFLKPHQDAQLKAKNLYRSCVNSAVLAKRGLE 464
                                                     |:.|.:..|.||:....:.:.|.:
Human   288 -----------------------------------------AEQKTQRFYLSCLQVERIEELGAQ 311

  Fly   465 PLHTLIRELGGWPVLESQWSESNFNWQVLAATLRRYNNDILIVQWVGADIKNSEENIVQFDQTGL 529
            ||..||.::|||.: ...|.:.|| .:||.|....|........::.||.|:|..|::|.||:||
Human   312 PLRDLIEKIGGWNI-TGPWDQDNF-MEVLKAVAGTYRATPFFTVYISADSKSSNSNVIQVDQSGL 374

  Fly   530 GLPTREYFL-QPSNAKYLQAYQRYMAEVMHKMGASKADAQRVASELVAFETQLAGITAPAEQRLN 593
            .||:|:|:| :.:|.|.|.||..||.|:...:|......:....:::..|.|||.||.|.:||.:
Human   375 FLPSRDYYLNRTANEKVLTAYLDYMEELGMLLGGRPTSTREQMQQVLELEIQLANITVPQDQRRD 439

  Fly   594 VTKLYKRMTLDQLQAVVPEIKWRAYLQ-SLQDREVLGTEEVVIYAVEYMSKLVTLLDETDPRTVS 657
            ..|:|.:|::.:|||:.|.:.|..:|. .|...|:..:|.||:|.::|:.::..|::.|:|..::
Human   440 EEKIYHKMSISELQALAPSMDWLEFLSFLLSPLELSDSEPVVVYGMDYLQQVSELINRTEPSILN 504

  Fly   658 NYMMWRFVRHRINNVDDRFDDIKQSFYHALFGREES-PQRWKVCIAQVNTNMGMAVGSMFVSRYF 721
            ||::|..|:...:::|.||:..::.....|:|.::| ..||:.||:..:..:|.|:||:||...|
Human   505 NYLIWNLVQKTTSSLDRRFESAQEKLLETLYGTKKSCVPRWQTCISNTDDALGFALGSLFVKATF 569

  Fly   722 DNNSKRDTLRMTHDLQQAFRDILKTTDWLDDTTKQLAEEKVNAMSLKIGYPDFILNPSELNSKYA 786
            |..||.....|..:::.||.:.|....|:|:.|:|.|:||.:|:...||:|||||.|.||:..|.
Human   570 DRQSKEIAEGMISEIRTAFEEALGQLVWMDEKTRQAAKEKADAIYDMIGFPDFILEPKELDDVYD 634

  Fly   787 GIEIYPEKYFENTLNVLLHTAKTEQAKLHERVNKTNWQTAPAIVNAYYSRNKNQIMFPAGILQPP 851
            |.||..:.:|:|.||:...:||....:|.:..::..|...|..|||||...||:|:|||||||.|
Human   635 GYEISEDSFFQNMLNLYNFSAKVMADQLRKPPSRDQWSMTPQTVNAYYLPTKNEIVFPAGILQAP 699

  Fly   852 FYHRHFPKSLNFGGIGVVIGHELTHGFDDKGRLFDRNGNIHKWWTDSSIRGFDERARCIIAQYSN 916
            ||.|:.||:|||||||||:||||||.|||:||.:|:.||:..||.:.|:..|.....|:..||:.
Human   700 FYARNHPKALNFGGIGVVMGHELTHAFDDQGREYDKEGNLRPWWQNESLAAFRNHTACMEEQYNQ 764

  Fly   917 YTVEEVGIVLNGESTQGENIADNGGLRQAFHAYQRWLKEHPSEVSDEILPGLNMTGPQLFFLNFG 981
            |.|.  |..|||..|.||||||||||:.|::||:.||::|..|   :.||.:.:|..||||:.|.
Human   765 YQVN--GERLNGRQTLGENIADNGGLKAAYNAYKAWLRKHGEE---QQLPAVGLTNHQLFFVGFA 824

  Fly   982 QVWCGAMRPEAIRNKLNTAIHSPGRFRVIGTLSNSVDFAREFNCPLGSPMNPQKKCSVW 1040
            ||||....||:....|.|..|||.||||:||||||.||.|.|.||:||||||.:.|.||
Human   825 QVWCSVRTPESSHEGLVTDPHSPARFRVLGTLSNSRDFLRHFGCPVGSPMNPGQLCEVW 883

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nep4	NP_650904.3	M13	274..1038	CDD:189000	270/766 (35%)
EEF1AKMT4-ECE2	NP_055508.3	Methyltransferase-like region. /evidence=ECO:0000305	1..160
		Methyltransf_25	62..>128	CDD:316196
		S-adenosyl-L-methionine binding. /evidence=ECO:0000250\|UniProtKB:P0DPD7	88..89
		S-adenosyl-L-methionine binding. /evidence=ECO:0000250\|UniProtKB:P0DPD7	113..114
		M13	232..881	CDD:189000	270/766 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150961
Domainoid	1	1.000	48	1.000	Domainoid score	I11915
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG61902
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100162
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.760