Protein Alignment Nep4 and ecel1

DIOPT Version :10

• Sequence 1: NP_650904.3
• Gene: Nep4 / 42449
• FlyBaseID: FBgn0038818
• Length: 1040
• Species: Drosophila melanogaster
• Sequence 2: XP_012818808.2
• Gene: ecel1 / 100496473
• XenbaseID: XB-GENE-989944
• Length: 764
• Species: Xenopus tropicalis
• Alignment Length: 882
• Identity: 268/882 - (30%)
• Similarity: 411/882 - (46%)
• Gaps: 172/882 - (19%)

  Fly   185 LGSGIELDIKPIDEEAYQRQKKRYQDIAPYWLEKIRIRERREA---------------------- 227
            |.:|..|.:.         .||:.:.:.|.|       .|||.
 Frog    29 LSNGFNLQVS---------SKKQTKKVVPRW-------SRRETCLLSGLVFAVGLCVILGCMLVL 77

  Fly   228 ERHAEEASAEISEATAALQSFWNEEGTREGIRMTQAKTMKRYMDNKVDPCVDFYKYACGNWERLH 292
            :..:.|...:..|.....::|           |..:|.:...:|..:.||.|||.:|||.|.|.|
 Frog    78 KYLSMEQDVQCLEGCQERKAF-----------MRASKFITNNIDPTISPCTDFYSFACGGWLRRH 131

  Fly   293 PIPKDKAGFDTFEMLRESLDLVLRNLLEKNTPVHSAAELRKSPVRNTLFKLNEQGEGEGEADQAA 357
            .||:||..:.|...:.|..:..|.:||             ..|||
 Frog   132 GIPEDKLIYGTIAAIGEQNEEKLEHLL-------------LQPVR-------------------- 163

  Fly   358 ELTAERLRRHIVSKRQLLNRVLVRYKRYTNGTKRKRLIETPRERTKEEEAAPPVVLPKDKTKDKS 422
                   |:|..|
 Frog   164 -------RKHKGS---------------------------------------------------- 169

  Fly   423 DNEEQLHVPTDFLKPHQDAQLKAKNLYRSCVNSAVLAKRGLEPLHTLIRELGGWPVLESQWSESN 487
                              |:.|.|..::||:|...:.:.|..|:..:|.:.|||.:.|...::.:
 Frog   170 ------------------AERKVKEFFKSCLNMRDIDRLGARPMLQVIEDCGGWDLPEDPRTQWD 216

  Fly   488 FNWQVLAATLRRYNNDILIVQWVGADIKNSEENIVQFDQTGLGLPTREYFL--QPSNAKYLQAYQ 550
            || ::|..|...|:..:.....|..|.|||...|::.||.||.||.|..:|  ...:.|.|:||:
 Frog   217 FN-ELLYKTQGVYSTAVFFSMTVSLDDKNSSRYIIRIDQDGLTLPERTLYLGQDEESIKVLEAYK 280

  Fly   551 RYMAEVMHKMGASKADAQRVASELVAFETQLAGITAPA--EQRLNVTKLYKRMTLDQLQAVVPEI 613
            .:|..::..:|..  :.|:.|.|::..|..|:.||...  :.|.:::.:|.::||.|||.:.|.:
 Frog   281 VFMQTILSLLGVE--NVQKKAEEILHLEQHLSNITISEFDDMRRDISTMYNKVTLAQLQQITPHL 343

  Fly   614 KWRAYLQSLQDREVLGTEEVVIYAVEYMSKLVTLLDETDPRTVSNYMMWRFVRHRINNVDDRFDD 678
            .|:..|..:........||||:.|.:||.|:..::..|....:.|||:||.|.....::...|.|
 Frog   344 NWKNLLNRIFHTNFPEDEEVVVLATDYMQKVSEMIRSTPASVLHNYMLWRIVVVLSEHLSTPFRD 408

  Fly   679 IKQSFYHALFGREESPQRWKVCIAQVNTNMGMAVGSMFVSRYFDNNSKRDTLRMTHDLQQAFRDI 743
            ........:.|.|:..:..|||:.|.|.:.|||:|::||..||.::||....::..:::......
 Frog   409 AIHELSKEMEGSEKQAELTKVCLTQANKHFGMALGALFVEEYFSSSSKAKVQQLVENIKHILDYR 473

  Fly   744 LKTTDWLDDTTKQLAEEKVNAMSLKIGYPDFILNPSELNSKYAGIEIYPEKYFENTLNVLLHTAK 808
            |:..||:|..|||.|.||:..|.:.|||||.:|.|..::.:|. .|:..:.||:|.||.:.::.|
 Frog   474 LEELDWMDTETKQAAREKLKHMMVMIGYPDVLLQPESMDKEYE-FEVNEKTYFKNILNSIRYSIK 537

  Fly   809 TEQAKLHERVNKTNWQTAPAIVNAYYSRNKNQIMFPAGILQPPFYHRHFPKSLNFGGIGVVIGHE 873
            ....::.:.|:|:.|...|..:||||..||||::||||||||..|...||:|||:||||.:||||
 Frog   538 MAVRRIRQEVDKSAWLLPPQALNAYYLPNKNQMVFPAGILQPTLYDPDFPQSLNYGGIGTIIGHE 602

  Fly   874 LTHGFDDKGRLFDRNGNIHKWWTDSSIRGFDERARCIIAQYSNYTVEEVGIVLNGESTQGENIAD 938
            ||||:||.|..:|.|||..:|||:.|...|.::|.||:..|.|:||....:  ||.:|.||||||
 Frog   603 LTHGYDDWGGQYDANGNPIQWWTEDSYSKFLKKAECIVDLYENFTVYNQRV--NGRTTLGENIAD 665

  Fly   939 NGGLRQAFHAYQRWLKEHPSEVSDEILPGLNMTGPQLFFLNFGQVWCGAMRPEAIRNKLNTAIHS 1003
            .|||:.|::|||:|::::..|   ..||.|..|..||||:.|.|.||...|.::|..::.|..|:
 Frog   666 LGGLKLAYYAYQKWVRDNGPE---RPLPRLKYTHDQLFFIAFAQNWCIKRRSQSIYLQVLTDKHA 727

  Fly  1004 PGRFRVIGTLSNSVDFAREFNCPLGSPMNPQKKCSVW 1040
            |..:||:|::|...:|.|.|:||..|||||..|||||
 Frog   728 PEHYRVMGSVSQFEEFGRVFHCPRNSPMNPVHKCSVW 764

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nep4	NP_650904.3	M13	274..1038	CDD:341056	248/767 (32%)
ecel1	XP_012818808.2	M13	113..762	CDD:341056	248/767 (32%)