Protein Alignment Nep4 and phex

DIOPT Version :10

• Sequence 1: NP_650904.3
• Gene: Nep4 / 42449
• FlyBaseID: FBgn0038818
• Length: 1040
• Species: Drosophila melanogaster
• Sequence 2: XP_004911718.1
• Gene: phex / 100496470
• XenbaseID: XB-GENE-1012247
• Length: 750
• Species: Xenopus tropicalis
• Alignment Length: 798
• Identity: 248/798 - (31%)
• Similarity: 392/798 - (49%)
• Gaps: 131/798 - (16%)

  Fly   263 AKTMKRYMDNKVDPCVDFYKYACGNWERLHPIPKDKAGFDTFEMLRESLDLVLRNLLEKNTPVHS 327
            |.:::..|:..||||.||::||||.|...:|||.|.:.:..:..||.::||.|:.||||.
 Frog    64 AASIRSKMNLSVDPCDDFFQYACGGWIEENPIPDDMSNYGIYPWLRTNVDLKLKALLEKP----- 123

  Fly   328 AAELRKSPVRNTLFKLNEQGEGEGEADQAAELTAERLRRHIVSKRQLLNRVLVRYKRYTNGTKRK 392
                                                     :|||:
 Frog   124 -----------------------------------------ISKRR------------------- 128

  Fly   393 RLIETPRERTKEEEAAPPVVLPKDKTKDKSDNEEQLHVPTDFLKPHQDAQLKAKNLYRSCVNSAV 457
                                          |:|               |..|.|..|.||:|...
 Frog   129 ------------------------------DSE---------------AIQKVKTFYISCMNETQ 148

  Fly   458 LAKRGLEPLHTLIRELG-GWPVLES------QWSESNFNWQVLAATLRR-YNNDILIVQWVGADI 514
            :.:..::|:..::::.. .||||||      :|||..|::....|.||| |:..:.:..:|..|.
 Frog   149 IEEDDIKPILKILKQPSLRWPVLESNIGSDGKWSERKFSFLQTVADLRRLYSTSVFLRVYVAIDD 213

  Fly   515 KNSEENIVQFDQTGLGLPTREYFLQPSN--AKYLQAYQRYMAEVMHKMGASKADAQRVASELVAF 577
            |.|...|::.||..|.|.:.|.:|..|.  .||..|...:|.:|...:||:|..|:.....|:..
 Frog   214 KVSNNFILKLDQASLSLLSHEDYLDNSTIAKKYRDALLEFMVDVAVLLGANKTRAETDMKALIEL 278

  Fly   578 ETQLAGITAPAEQRLNVTKLYKRMTLDQLQAVVPEIKWRAYLQSLQD-------REVLGTEEVVI 635
            ||:||.||.|.|.|.: ..:|.:|.:.:|.|::|:..|.:||:::.|       :.:..:|.|::
 Frog   279 ETKLAQITVPQENRTS-EMMYNKMNISELSAMIPQFDWLSYLKNIIDFNIYPELKNIDLSENVIV 342

  Fly   636 YAVEYMSKLVTLLDETDPRTVSNYMMWRFVRHRINNVDDRFDDIKQSFYHALFGREESPQRWKVC 700
            ...::...|..:::..:.||::||::||.|..||.|:..||...:..|...|.|......||..|
 Frog   343 RVPQHFKDLFNIIESEEKRTLANYLIWRLVYSRIPNLSRRFQYRQLEFARILLGTNSLAGRWDRC 407

  Fly   701 IAQVNTNMGMAVGSMFVSRYFDNNSKRDTLRMTHDLQQAFRDIL-KTTDWLDDTTKQLAEEKVNA 764
            :..|..::...||.:||..:|..:.|.....:...::.||.|:| |..||:|..||..|::|...
 Frog   408 VNYVENSIPYPVGKLFVDAHFQEDKKDMMEELVDGIRWAFIDMLEKENDWMDAETKIKAKQKAVT 472

  Fly   765 MSLKIGYPDFILNPSELNSKYAGIEIYPEKYFENTLNVLLHTAKTEQAKLHERVNKTNWQTAPAI 829
            :..|:|||:|:.|.:.||.....::.....||.|.|..|...::::...|...|.|..|.|.|..
 Frog   473 VMAKVGYPEFLFNDTYLNEDIKMLKFSESDYFGNVLQTLHFISQSDFYWLRRNVPKKEWFTNPTT 537

  Fly   830 VNAYYSRNKNQIMFPAGILQPPFYHR-HFPKSLNFGGIGVVIGHELTHGFDDKGRLFDRNGNIHK 893
            |||:||.:.|||.||||.||.||:.. .:|:||::|.|||::|||.|||||:.||.:|:.||:..
 Frog   538 VNAFYSASTNQIRFPAGELQKPFFWGVQYPRSLSYGAIGVIVGHEFTHGFDNNGRKYDKEGNLFS 602

  Fly   894 WWTDSSIRGFDERARCIIAQYSNYTVEEVGIVLNGESTQGENIADNGGLRQAFHAYQRWLKEHPS 958
            |||..|...|..:..|::.||:||..::.|:.:.|..|..||||||||:|::|.||::|:::...
 Frog   603 WWTSESEERFKNKTLCMVEQYNNYYWKQAGLHVKGMKTLSENIADNGGIRESFRAYRKWIEDLRK 667

  Fly   959 EVSDEILPGLNMTGPQLFFLNFGQVWCGAMRPEAIRNKLNTAIHSPGRFRVIGTLSNSVDFAREF 1023
            ...:.:||||::...||||:::..|.|.:.|.|:.|:::...:|||.:|||||.:||..:|.:.|
 Frog   668 GKEEMLLPGLDLNNNQLFFISYAHVRCNSFRIESARDQIMNGVHSPPQFRVIGAMSNFEEFHKAF 732

  Fly  1024 NCPLGSPMN-PQKKCSVW 1040
            :||..|.|| ....|.||
 Frog   733 SCPKDSKMNRGANSCRVW 750

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nep4	NP_650904.3	M13	274..1038	CDD:341056	243/783 (31%)
phex	XP_004911718.1	M13	75..741	CDD:341056	241/776 (31%)