Protein Alignment Nep4 and ece1

DIOPT Version :10

• Sequence 1: NP_650904.3
• Gene: Nep4 / 42449
• FlyBaseID: FBgn0038818
• Length: 1040
• Species: Drosophila melanogaster
• Sequence 2: XP_031762312.1
• Gene: ece1 / 100485607
• XenbaseID: XB-GENE-1014218
• Length: 782
• Species: Xenopus tropicalis
• Alignment Length: 917
• Identity: 293/917 - (31%)
• Similarity: 452/917 - (49%)
• Gaps: 186/917 - (20%)

  Fly   153 YGNGESMELE--ERNTLMKDSRTSFLPLGIPRECLGSGIELDIKPIDEEAYQRQKKRYQDIAPYW 215
            :|:|...|:.  :|.||.::.....|..|   |...:|::::::.:            :..:..|
 Frog    23 FGSGTPGEMSAYKRATLDEEDLVDSLGEG---EVYPNGLQVNLRGV------------RPRSGCW 72

  Fly   216 LEKIRIRER-----------------------REAERHAEEASAEISEATAALQSFWNEEGTREG 257
            .|:..:.:|                       |.:.|..      :||:..::.|
 Frog    73 AERTHVEKRLLVLVVLLSLGLFMCLLALSLQYRNSHRVC------LSESCISVTS---------- 121

  Fly   258 IRMTQAKTMKRYMDNKVDPCVDFYKYACGNWERLHPIPKDKAGFDTFEMLRESLDLVLRNLLEKN 322
                   ::.|.:|...|||.|||:|:||.|.:.:|:|...:.:.||..|.|.....:::|||.:
 Frog   122 -------SILRSLDRSADPCQDFYQYSCGGWIKGNPVPDGHSRWGTFNELWEHNQATMKHLLENS 179

  Fly   323 TPVHSAAELRKSPVRNTLFKLNEQGEGEGEADQAAELTAERLRRHIVSKRQLLNRVLVRYKRYTN 387
            |
 Frog   180 T---------------------------------------------------------------- 180

  Fly   388 GTKRKRLIETPRERTKEEEAAPPVVLPKDKTKDKSDNEEQLHVPTDFLKPHQDAQLKAKNLYRSC 452
                   |||                                        :..|:.||:..:::|
 Frog   181 -------IET----------------------------------------NSTAERKAQRYFQAC 198

  Fly   453 VNSAVLAKRGLEPLHTLIRELGGWPVLESQWSESNFNWQVLAATLRRYNNDILIVQWVGADIKNS 517
            :|...:.:.|.:||..||::|||| .:...|...||. :.|......|........:|.||.|||
 Frog   199 MNETKIEELGAKPLQDLIQKLGGW-AITGPWDRDNFQ-ETLQLVTAHYRTSPFFSVFVSADSKNS 261

  Fly   518 EENIVQFDQTGLGLPTREYFL-QPSNAKYLQAYQRYMAEVMHKMGASKADAQRVASELVAFETQL 581
            ..|::|.||:|||||:||::| :..|.|.|..|..:|.::...:|.::...:....|::.|||.|
 Frog   262 NSNVIQIDQSGLGLPSREFYLNKTENEKVLTGYLNFMIQLGVLLGGAENSTREQMQEILDFETTL 326

  Fly   582 AGITAPAEQRLNVTKLYKRMTLDQLQAVVPEIKWRAYLQSL-QDREVLGTEEVVIYAVEYMSKLV 645
            |.||.|.|:|.:..::|.:|...:|:.:||.:.|..:||:: ....:..:|.||:||.||:..:.
 Frog   327 ANITIPQEKRRDEEQIYHKMAAGELKDLVPAVDWMPFLQTVFYPVAINESEPVVVYAKEYLVAVS 391

  Fly   646 TLLDETDPRTVSNYMMWRFVRHRINNVDDRFDDIKQSFYHALFGREES--PQRWKVCIAQVNTNM 708
            .|::.||.|.::|||||..||...:.:|.||.|.::.....::|.:::  | |||.||:..:.|:
 Frog   392 GLINSTDKRILNNYMMWNLVRKASSFLDQRFQDAEEKLMEVMYGTKKTCLP-RWKFCISDTDNNL 455

  Fly   709 GMAVGSMFVSRYFDNNSKRDTLRMTHDLQQAFRDILKTTDWLDDTTKQLAEEKVNAMSLKIGYPD 773
            |.|:|:|||...|..|||...|:|..:::.||.:.|.|..|:||.|::.|.||..|:...||||:
 Frog   456 GFALGAMFVKATFAENSKLQALKMIKEIKAAFEENLSTLTWMDDETRRAAREKAEAIYDMIGYPN 520

  Fly   774 FILNPSELNSKYAGIEIYPEKYFENTLNVLLHTAKTEQAKLHERVNKTNWQTAPAIVNAYYSRNK 838
            ||::|.||:..:....:..:.||||.:.....:|:....:|.:..:|..|...|..||||||..|
 Frog   521 FIMDPKELDKVFNDYNVTSDFYFENGMRFYNFSARVTADQLRKAPSKDQWSMTPPTVNAYYSPTK 585

  Fly   839 NQIMFPAGILQPPFYHRHFPKSLNFGGIGVVIGHELTHGFDDKGRLFDRNGNIHKWWTDSSIRGF 903
            |:|:|||||||.|||....|.:|||||||||:||||||.|||:||.:|::||:..||.::|:..|
 Frog   586 NEIVFPAGILQAPFYTSSSPTALNFGGIGVVMGHELTHAFDDQGREYDKDGNLRPWWKNASVEAF 650

  Fly   904 DERARCIIAQYSNYTVEEVGIVLNGESTQGENIADNGGLRQAFHAYQRWLKEHPSEVSDEILPGL 968
            .::..||..||.||||.  |..:||..|.||||||||||:.|:.||:.|::::.:|   ::||.|
 Frog   651 KKQTECITEQYGNYTVN--GEPVNGRQTLGENIADNGGLKAAYRAYKNWVRKNGAE---QLLPSL 710

  Fly   969 NMTGPQLFFLNFGQVWCGAMRPEAIRNKLNTAIHSPGRFRVIGTLSNSVDFAREFNCPLGSPMNP 1033
            .::..||||:.|.||||.....|:....|.|..|||.||||||::|||.:||..|.||.||||||
 Frog   711 GLSNDQLFFVGFAQVWCSVRTSESSHEGLITDPHSPSRFRVIGSVSNSQEFAEHFRCPPGSPMNP 775

  Fly  1034 QKKCSVW 1040
            :.||.||
 Frog   776 RNKCEVW 782

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nep4	NP_650904.3	M13	274..1038	CDD:341056	270/767 (35%)
ece1	XP_031762312.1	M13	131..780	CDD:341056	270/767 (35%)