Protein Alignment Nep4 and mmel1

DIOPT Version :10

• Sequence 1: NP_650904.3
• Gene: Nep4 / 42449
• FlyBaseID: FBgn0038818
• Length: 1040
• Species: Drosophila melanogaster
• Sequence 2: XP_012821551.1
• Gene: mmel1 / 100145721
• XenbaseID: XB-GENE-991673
• Length: 765
• Species: Xenopus tropicalis
• Alignment Length: 800
• Identity: 274/800 - (34%)
• Similarity: 433/800 - (54%)
• Gaps: 134/800 - (16%)

  Fly   260 MTQAKTMKRYMDNKVDPCVDFYKYACGNWERLHPIPKDKAGFDTFEMLRESLDLVLRNLLEKNTP 324
            :|.|..:.:.||..::||.|||:||||.|...|.||:..:.:..|::||:.::::|:.|||
 Frog    81 VTAAARIIQNMDPTIEPCTDFYQYACGGWLNKHVIPETSSRYSIFDILRDEMEIILKGLLE---- 141

  Fly   325 VHSAAELRKSPVRNTLFKLNEQGEGEGEADQAAELTAERLRRHIVSKRQLLNRVLVRYKRYTNGT 389
                                                                             
 Frog   142 ----------------------------------------------------------------- 141

  Fly   390 KRKRLIETPRERTKEEEAAPPVVLPKDKTKDKSDNEEQLHVPTDFLKPHQDAQLKAKNLYRSCVN 454
                                   :|        |.|:            :||..|||.||:||:|
 Frog   142 -----------------------MP--------DQED------------RDAFKKAKILYKSCMN 163

  Fly   455 SAVLAKRGLEPLHTLIRELGGWPVLESQWS---ESNFNWQVLAATLR-RYNNDILIVQWVGADIK 515
            .:::.:|...||..|:..:|.|||..:.|:   |||::.:...:.|. ::|..:|:..:|..|.:
 Frog   164 ESLIEQRDSLPLLELLTTVGEWPVASTDWNGTKESNWSLEEKLSLLNYKFNKRVLVDIFVWNDDR 228

  Fly   516 NSEENIVQFDQTGLGLPTREYFLQPSNAKYL-QAYQRYMAEVMHKM----GASKADA--QRVASE 573
            .|.::|:..||..||:|:|:|:....|.:.: :||.::|..:...:    ..::.|:  |...:.
 Frog   229 ESSKHIIYIDQPSLGMPSRDYYFNKGNYQRIREAYLQFMITIARMVREDRNLTRDDSLVQEEMTR 293

  Fly   574 LVAFETQLAGITAPAEQRLNVTKLYKRMTLDQLQA--VVPEIKWRAYLQSLQDR---EVLGTEEV 633
            ::..||.:|..|||:|:|.:||.||.:|||.:.|.  .:.:..|.:::|.:...   ::...|||
 Frog   294 VMDLETDIARATAPSEERNDVTLLYNKMTLLEFQQKFALDDFNWTSFIQGVMSSVNIQLQAEEEV 358

  Fly   634 VIYAVEYMSKLVTLLDETDPRTVSNYMMWRFVRHRINNVDDRFDDIKQSFYHALFGREESPQRWK 698
            |:|...|:.:|..:|......|:.||::||.|..|::::..|:.|.:.|:..||:|......||:
 Frog   359 VVYGAPYLHQLKNILSNYSASTLQNYVVWRMVIDRVSSLSRRYKDARASYRKALYGTTLEEARWR 423

  Fly   699 VCIAQVNTNMGMAVGSMFVSRYFDNNSKRDTLRMTHDLQQAFRDILKTTDWLDDTTKQLAEEKVN 763
            .|::.||:||..|||:|:|...|...|||....:.:.:::||.:.|....|:|:|:|..|.||..
 Frog   424 ECVSYVNSNMENAVGAMYVKETFAGESKRMISDLINKVREAFIETLDELQWMDETSKDKAREKAL 488

  Fly   764 AMSLKIGYPDFILNP--SELNSKYAGIEIYPEKYFENTLNVLLHTAKTEQAKLHERVNKTNWQTA 826
            ::..:|||||:||..  .:|:.:.|.:.....:||||.|.:|...|:....||.|.|::..|...
 Frog   489 SIKEQIGYPDYILEDQNDKLDQETAALNFSEYQYFENILEILNSGAQKSLKKLREPVDQDAWIIG 553

  Fly   827 PAIVNAYYSRNKNQIMFPAGILQPPFYHRHFPKSLNFGGIGVVIGHELTHGFDDKGRLFDRNGNI 891
            .|:.:|:||.|:|||:||||||||||:::|.|::|||||||:|||||:||||||.||.||::||:
 Frog   554 AAVADAFYSPNRNQIVFPAGILQPPFFNKHQPQALNFGGIGMVIGHEITHGFDDNGRNFDKDGNM 618

  Fly   892 HKWWTDSSIRGFDERARCIIAQYSNYTVEEV-GIVLNGESTQGENIADNGGLRQAFHAYQRWLKE 955
            ..||::.|...|.:::||::.||.|||.|.. |..::|..|.|||||||||:|||:.||.:|::.
 Frog   619 FDWWSNFSAMHFKDQSRCMVYQYGNYTWELAGGQNVSGIITLGENIADNGGVRQAYKAYLKWVER 683

  Fly   956 HPSEVSDEILPGLNMTGPQLFFLNFGQVWCGAMRPEAIRNKLNTAIHSPGRFRVIGTLSNSVDFA 1020
            |..|..   ||||::|..|||||||.|||||:.|||..|:.:.|.:|||.::||:|:|.|...||
 Frog   684 HGKEPK---LPGLDLTYKQLFFLNFAQVWCGSYRPEYARHSIKTDVHSPFKYRVMGSLQNFEAFA 745

  Fly  1021 REFNCPLGSPMNPQKKCSVW 1040
            .||||..|:.|:|.:||.||
 Frog   746 EEFNCKKGTKMHPVEKCRVW 765

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nep4	NP_650904.3	M13	274..1038	CDD:341056	267/782 (34%)
mmel1	XP_012821551.1	M13	95..763	CDD:341056	267/782 (34%)