DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lrrk and RIPK2

DIOPT Version :9

Sequence 1:	NP_001262772.1	Gene:	Lrrk / 42447	FlyBaseID:	FBgn0038816	Length:	2513	Species:	Drosophila melanogaster
Sequence 2:	NP_003812.1	Gene:	RIPK2 / 8767	HGNCID:	10020	Length:	540	Species:	Homo sapiens

Alignment Length:	461	Identity:	113/461 - (24%)
Similarity:	188/461 - (40%)	Gaps:	86/461 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly  1779 DVIFADIPDKHTIPSECIIKGSLLGRGAFGFVFKANCKVRGARSFKPVAMKMLQ---PVPPGARA 1840
            :.|.:.:|   |||...:.....|.|||.|.|..|    |.|.....||:|.|.   |:....|
Human     4 EAICSALP---TIPYHKLADLRYLSRGASGTVSSA----RHADWRVQVAVKHLHIHTPLLDSER- 60

  Fly  1841 KESALMAFKVAVGKWDRDPLQHSCKAYCTARQELAVLLTLKHPNIVPLVGICIKP--LALVLELA 1903
                            :|.|           :|..:|...:...|:|::|||.:|  |.:|.|..
Human    61 ----------------KDVL-----------REAEILHKARFSYILPILGICNEPEFLGIVTEYM 98

  Fly  1904 PLGGLDALLRHYRRSGAHMGPHTFQTLVLQAARAIEYLHRRR--IIYRDLKSENVLVWELPQPHT 1966
            |.|.|:.||...........|..|: ::.:.|..:.|||...  :::.|||::|:|:
Human    99 PNGSLNELLHRKTEYPDVAWPLRFR-ILHEIALGVNYLHNMTPPLLHHDLKTQNILL-------- 154

  Fly  1967 EDSPRNLVHIKIADYGISR-------QTAPSGAKGFGGTEGFMAPEIIRYNGEEEYTEKVDCFSF 2024
                .|..|:||||:|:|:       |:..|.:...|||..:|.||......:...:.|.|.:|:
Human   155 ----DNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSY 215

  Fly  2025 GMFIYENISLRQPFEGHES---IKECILEGSRPALTQRETQFP----TCCLDLMVLCWHEQPRRR 2082
            .:..:|.:|.:||||...:   |...:.:|.||.:.:....:.    ...:.|:...|.:.|..|
Human   216 AVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDER 280

  Fly  2083 PT----ASQIVSILSAPECIHLLDVVAMPHSEKIVCGVFQSLVGMGDDERCGLELWLP-SFGSRI 2142
            |:    ..::..:|...|.|..|:.|......|:..  ..|.:.:.|.::..|.|.:| :.|.:.
Human   281 PSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQS--VSSAIHLCDKKKMELSLNIPVNHGPQE 343

  Fly  2143 DILDCSPSGSLLQCNSISCSPQPQVAPPKTPENGANSRARSAQRLPKMNMLCCCLVGEAIWMGDV 2207
            :  .|..|    |.:..|.||:...:.|...:|  :..:|.||....|.:..|  .|...|...:
Human   344 E--SCGSS----QLHENSGSPETSRSLPAPQDN--DFLSRKAQDCYFMKLHHC--PGNHSWDSTI 398

  Fly  2208 SGNLHA 2213
            ||:..|
Human   399 SGSQRA 404

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lrrk	NP_001262772.1	Ank_2	111..200	CDD:289560
		ANK	146..286	CDD:238125
		ANK repeat	146..177	CDD:293786
		Ank_4	179..232	CDD:290365
		ANK repeat	179..209	CDD:293786
		Ank_2	216..389	CDD:289560
		ANK	361..477	CDD:238125
		ANK repeat	361..390	CDD:293786
		Ank_2	364..464	CDD:289560
		ANK repeat	406..435	CDD:293786
		ANK repeat	437..464	CDD:293786
		LRR_8	<544..580	CDD:290566
		leucine-rich repeat	547..569	CDD:275380
		LRR_8	569..629	CDD:290566
		leucine-rich repeat	570..595	CDD:275380
		leucine-rich repeat	596..618	CDD:275380
		leucine-rich repeat	619..641	CDD:275380
		leucine-rich repeat	642..676	CDD:275380
		leucine-rich repeat	677..730	CDD:275380
		LRR_8	729..788	CDD:290566
		leucine-rich repeat	731..754	CDD:275380
		LRR_8	855..933	CDD:290566
		leucine-rich repeat	855..901	CDD:275380
		leucine-rich repeat	902..924	CDD:275380
		leucine-rich repeat	925..949	CDD:275380
		P-loop_NTPase	993..1211	CDD:304359
		COR	1230..1471	CDD:292713
		STYKc	1796..2092	CDD:214568	78/320 (24%)
		STKc_LRRK	1801..2095	CDD:270902	79/318 (25%)
RIPK2	NP_003812.1	STKc_RIP2	20..303	CDD:270928	81/327 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	338..369		8/36 (22%)
		CARD_RIP2_CARD3	438..524	CDD:176764
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0192
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900