DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lrrk and RIPK1

DIOPT Version :9

Sequence 1:	NP_001262772.1	Gene:	Lrrk / 42447	FlyBaseID:	FBgn0038816	Length:	2513	Species:	Drosophila melanogaster
Sequence 2:	NP_001341859.1	Gene:	RIPK1 / 8737	HGNCID:	10019	Length:	671	Species:	Homo sapiens

Alignment Length:	451	Identity:	106/451 - (23%)
Similarity:	169/451 - (37%)	Gaps:	142/451 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly  1776 LAPDVIFADIPDKHTIPSECIIKGSLLGRGAFGFVFKANCKVRGARSFKPVAMKMLQPVPPGARA 1840
            :.||:....|..|    |...::.:.|..|.||.|.....:.:|.     :.||.:...|.....
Human     1 MQPDMSLNVIKMK----SSDFLESAELDSGGFGKVSLCFHRTQGL-----MIMKTVYKGPNCIEH 56

  Fly  1841 KESALMAFKVAVGKWDRDPLQHSCKAYCTARQELAVLLTLKHPNIVPLVGICIK--PLALVLELA 1903
            .|:.|                          :|..::..|:|..:|.|:|:.|:  ..:||:|..
Human    57 NEALL--------------------------EEAKMMNRLRHSRVVKLLGVIIEEGKYSLVMEYM 95

  Fly  1904 PLGGLDALLRHYRRSGAHMG-PHTFQ-TLVLQAARAIEYLHRRRIIYRDLKSENVLVWELPQPHT 1966
            ..|.|..:|:      |.|. |.:.: .::|:....:.|||.:.:|::|||.||:||
Human    96 EKGNLMHVLK------AEMSTPLSVKGRIILEIIEGMCYLHGKGVIHKDLKPENILV-------- 146

  Fly  1967 EDSPRNLVHIKIADYGISR---------------QTAPSGAKGFGGTEGFMAPEIIRYNGEEEYT 2016
                .|..||||||.|::.               :.....||..|||..:||||.:. :...:.|
Human   147 ----DNDFHIKIADLGLASFKMWSKLNNEEHNELREVDGTAKKNGGTLYYMAPEHLN-DVNAKPT 206

  Fly  2017 EKVDCFSFGMFIYENISLRQPFEG---HESIKECILEGSRPALTQRETQFPTCCLDLMVLCWHEQ 2078
            ||.|.:||.:.::...:.::|:|.   .:.:..||..|:||.:.......|...:.||.|||...
Human   207 EKSDVYSFAVVLWAIFANKEPYENAICEQQLIMCIKSGNRPDVDDITEYCPREIISLMKLCWEAN 271

  Fly  2079 PRRRPT------------ASQIV------------------SILSAPECIHLLDVVAMPHSEKIV 2113
            |..|||            .||:.                  :::...:.:. ||.||:|.|....
Human   272 PEARPTFPGIEEKFRPFYLSQLEESVEEDVKSLKKEYSNENAVVKRMQSLQ-LDCVAVPSSRSNS 335

  Fly  2114 C----GVFQSL--VGMGDDERCGLELWL------------PS-------------FGSRID 2143
            .    |...|.  :|||..|    |.|.            ||             :|||:|
Human   336 ATEQPGSLHSSQGLGMGPVE----ESWFAPSLEHPQEENEPSLQSKLQDEANYHLYGSRMD 392

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lrrk	NP_001262772.1	Ank_2	111..200	CDD:289560
		ANK	146..286	CDD:238125
		ANK repeat	146..177	CDD:293786
		Ank_4	179..232	CDD:290365
		ANK repeat	179..209	CDD:293786
		Ank_2	216..389	CDD:289560
		ANK	361..477	CDD:238125
		ANK repeat	361..390	CDD:293786
		Ank_2	364..464	CDD:289560
		ANK repeat	406..435	CDD:293786
		ANK repeat	437..464	CDD:293786
		LRR_8	<544..580	CDD:290566
		leucine-rich repeat	547..569	CDD:275380
		LRR_8	569..629	CDD:290566
		leucine-rich repeat	570..595	CDD:275380
		leucine-rich repeat	596..618	CDD:275380
		leucine-rich repeat	619..641	CDD:275380
		leucine-rich repeat	642..676	CDD:275380
		leucine-rich repeat	677..730	CDD:275380
		LRR_8	729..788	CDD:290566
		leucine-rich repeat	731..754	CDD:275380
		LRR_8	855..933	CDD:290566
		leucine-rich repeat	855..901	CDD:275380
		leucine-rich repeat	902..924	CDD:275380
		leucine-rich repeat	925..949	CDD:275380
		P-loop_NTPase	993..1211	CDD:304359
		COR	1230..1471	CDD:292713
		STYKc	1796..2092	CDD:214568	81/347 (23%)
		STKc_LRRK	1801..2095	CDD:270902	81/345 (23%)
RIPK1	NP_001341859.1	STKc_RIP1	23..290	CDD:270929	79/316 (25%)
		Interaction with SQSTM1. /evidence=ECO:0000269\|PubMed:10356400	290..582		22/108 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	331..354		6/22 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	389..458		3/4 (75%)
		RIP homotypic interaction motif (RHIM). /evidence=ECO:0000269\|PubMed:11734559, ECO:0000269\|PubMed:29681455	531..547
		Death_RIP1	583..668	CDD:260048
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0192
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900