DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lrrk and MAP3K21

DIOPT Version :9

Sequence 1:	NP_001262772.1	Gene:	Lrrk / 42447	FlyBaseID:	FBgn0038816	Length:	2513	Species:	Drosophila melanogaster
Sequence 2:	NP_115811.2	Gene:	MAP3K21 / 84451	HGNCID:	29798	Length:	1036	Species:	Homo sapiens

Alignment Length:	478	Identity:	114/478 - (23%)
Similarity:	186/478 - (38%)	Gaps:	137/478 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly  1703 SEDSLGAGSDADSGVG-------PDSAGS--------------SRNTSVDGHPGYH--------- 1737
            |..|..:|..|.:|.|       .::.|.              |::.:|.|..|:.
Human    26 SSSSTSSGGSASAGAGLWAALYDYEARGEDELSLRRGQLVEVLSQDAAVSGDEGWWAGQVQRRLG 90

  Fly  1738 -LPDNSNVCYAWMIEECILSVYNQSKISCPVHLEQSMAQLAPDVIFADIPDKHTIPSECIIKGSL 1801
             .|.|    |..............|:.|.|||:.....:|.                      .|
Human    91 IFPAN----YVAPCRPAASPAPPPSRPSSPVHVAFERLELK----------------------EL 129

  Fly  1802 LGRGAFGFVFKANCKVRGARSFKPVAMKMLQPVPPGARAKESALMAFKVAVGKWDRDPLQHSCKA 1866
            :|.|.||.|::|..:.:                              :|||....:||.|.:..|
Human   130 IGAGGFGQVYRATWQGQ------------------------------EVAVKAARQDPEQDAAAA 164

  Fly  1867 YCTARQELAVLLTLKHPNIVPLVGICIKP--LALVLELAPLGGLDALL--------------RHY 1915
            ..:.|:|..:...|:||||:.|.|:|::.  |.||||.|..|.|:..|              |..
Human   165 AESVRREARLFAMLRHPNIIELRGVCLQQPHLCLVLEFARGGALNRALAAANAAPDPRAPGPRRA 229

  Fly  1916 RRSGAHMGPHTFQTLVLQAARAIEYLHRRR---IIYRDLKSENVLVWELPQPHTEDSPRNLVHIK 1977
            ||    :.||......:|.||.:.|||...   |::|||||.|:|:.|..: |.:...:.|   |
Human   230 RR----IPPHVLVNWAVQIARGMLYLHEEAFVPILHRDLKSSNILLLEKIE-HDDICNKTL---K 286

  Fly  1978 IADYGISRQTAPSGAKGFGGTEGFMAPEIIRYNGEEEYTEKVDCFSFGMFIYENISLRQPFEGHE 2042
            |.|:|::|:...:......||..:||||:|:   ...:::..|.:|:|:.::|.::...|:.|.:
Human   287 ITDFGLAREWHRTTKMSTAGTYAWMAPEVIK---SSLFSKGSDIWSYGVLLWELLTGEVPYRGID 348

  Fly  2043 SIKECILEGSRPALTQRETQFPTCCLD----LMVLCWHEQPRRRPTASQIVSILSAPECIHLLDV 2103
            .:  .:..|  .|:.:.....|:.|.:    ||..||.:.|..||:.:.|:..|:|.|...:.:
Human   349 GL--AVAYG--VAVNKLTLPIPSTCPEPFAKLMKECWQQDPHIRPSFALILEQLTAIEGAVMTE- 408

  Fly  2104 VAMPHSEKIVCGVFQSLVGMGDD 2126
              ||.         :|...|.||
Human   409 --MPQ---------ESFHSMQDD 420

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lrrk	NP_001262772.1	Ank_2	111..200	CDD:289560
		ANK	146..286	CDD:238125
		ANK repeat	146..177	CDD:293786
		Ank_4	179..232	CDD:290365
		ANK repeat	179..209	CDD:293786
		Ank_2	216..389	CDD:289560
		ANK	361..477	CDD:238125
		ANK repeat	361..390	CDD:293786
		Ank_2	364..464	CDD:289560
		ANK repeat	406..435	CDD:293786
		ANK repeat	437..464	CDD:293786
		LRR_8	<544..580	CDD:290566
		leucine-rich repeat	547..569	CDD:275380
		LRR_8	569..629	CDD:290566
		leucine-rich repeat	570..595	CDD:275380
		leucine-rich repeat	596..618	CDD:275380
		leucine-rich repeat	619..641	CDD:275380
		leucine-rich repeat	642..676	CDD:275380
		leucine-rich repeat	677..730	CDD:275380
		LRR_8	729..788	CDD:290566
		leucine-rich repeat	731..754	CDD:275380
		LRR_8	855..933	CDD:290566
		leucine-rich repeat	855..901	CDD:275380
		leucine-rich repeat	902..924	CDD:275380
		leucine-rich repeat	925..949	CDD:275380
		P-loop_NTPase	993..1211	CDD:304359
		COR	1230..1471	CDD:292713
		STYKc	1796..2092	CDD:214568	85/318 (27%)
		STKc_LRRK	1801..2095	CDD:270902	86/316 (27%)
MAP3K21	NP_115811.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..36		3/9 (33%)
		SH3_MLK4	42..97	CDD:212991	7/58 (12%)
		PKc_like	129..401	CDD:328722	86/316 (27%)
		Leucine-zipper 1	425..446
		Leucine-zipper 2	460..481
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	517..551
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	748..791
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	923..954
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0192
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900