DRSC/TRiP Functional Genomics Resources

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Protein Alignment Lrrk and AT1G62950

DIOPT Version :9

Sequence 1:NP_001262772.1 Gene:Lrrk / 42447 FlyBaseID:FBgn0038816 Length:2513 Species:Drosophila melanogaster
Sequence 2:NP_176483.1 Gene:AT1G62950 / 842597 AraportID:AT1G62950 Length:890 Species:Arabidopsis thaliana


Alignment Length:684 Identity:137/684 - (20%)
Similarity:245/684 - (35%) Gaps:200/684 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly   481 NVFLPSTSNISYSAMFPNNPTIIDWHSMGSSVQLSVVRVPWMV------SGVLLLNPKLQSHPRL 539
            |.|.....|..:...:......:..:::..|:..|:|....::      :|:..|.|::...|.|
plant   155 NAFFGEIPNSLFKFCYKTKFVSLSHNNLSGSIPESIVNCNNLIGFDFSYNGITGLLPRICDIPVL 219

  Fly   540 NEVAL----------------TAITRIDFSHNVLTSIPQ-ELFHLVSLRYLNVAQNKITDLPAPI 587
            ..|::                ..::.:|...|....:.. |:....:|.|.||:.|:..   ..|
plant   220 EFVSVRRNLLSGDVFEEISKCKRLSHVDIGSNSFDGVASFEVIGFKNLTYFNVSGNRFR---GEI 281

  Fly   588 GQTYGC-PVLDELFLQDNQLT-TLPAAIFHLPALSILDVSNNKLQ-QLPFDLWRAPKLRELNVAF 649
            |:...| ..|:.|....|:|| .:|:.|....:|.:||:.:|:|. .:|..:.:..||..:.:..
plant   282 GEIVDCSESLEFLDASSNELTGNVPSGITGCKSLKLLDLESNRLNGSVPVGMGKMEKLSVIRLGD 346

  Fly   650 NLLRDLPVPPMQTSS----SLLSLDKLNLQSFEEPPSNKPRNVTQQRLTHRNLWSATLDITDNDM 710
            |.: |..: |::..:    .:|:|..|||      ....|.:::..||.      ..||::.|.:
plant   347 NFI-DGKL-PLELGNLEYLQVLNLHNLNL------VGEIPEDLSNCRLL------LELDVSGNGL 397

  Fly   711 KWQ----------------HEQDLGDGKTAGVGS-SQLSSLNIANNLFTS-IPAALPCLAVNLTR 757
            :.:                |...:.......:|| |::..|:::.||.:. ||::|..|. .||.
plant   398 EGEIPKNLLNLTNLEILDLHRNRISGNIPPNLGSLSRIQFLDLSENLLSGPIPSSLENLK-RLTH 461

  Fly   758 LNMSYNSLRSMGHVTSYPATLKQLDLSHNEISCWPSLPRITESDPHLLCYSCVQLPEGRDDDYKT 822
            .|:|||:|  .|.:....|: .....|:|...|         .||  |...|..|..|.    ::
plant   462 FNVSYNNL--SGIIPKIQAS-GASSFSNNPFLC---------GDP--LETPCNALRTGS----RS 508

  Fly   823 ASSKGSSSSATSF---RASVLKSVC---------RHRRHLRLEALRTLILADNLLTRIQLSTDDA 875
            ..:|..|:|....   .|::|..:|         |.||..|.|.:.|.    :..|..|.||:..
plant   509 RKTKALSTSVIIVIIAAAAILVGICLVLVLNLRARKRRKKREEEIVTF----DTTTPTQASTESG 569

  Fly   876 T--------TLFNE---SEDADW-----------SVVGVNRSKVIF------------PNLSMLD 906
            .        .||::   |:..||           :::|:.....::            ..|..|.
plant   570 NGGVTFGKLVLFSKSLPSKYEDWEAGTKALLDKDNIIGIGSIGAVYRASFEGGVSIAVKKLETLG 634

  Fly   907 MTNNCLKEIPASLHELSSLSVLNISGNVNITELPPHLGLLSRLWNLNTRGCLLQEPLRSMIESKK 971
            ...| .:|....:..|.|||             .|:|......:..:|...:|.|.:.:      
plant   635 RIRN-QEEFEQEIGRLGSLS-------------HPNLASFQGYYFSSTMQLILSEFVTN------ 679

  Fly   972 HKTMDIVGYLKSIYEDAQPYARMKLMVVGVAGIGKSTLLDLLRQGAGSGSSSSSHRSRASENHWA 1036
                      .|:|::..|                       |....:.||||||.:  :|.:|.
plant   680 ----------GSLYDNLHP-----------------------RVSHRTSSSSSSHGN--TELNWH 709

  Fly  1037 KR----MGHARSTSRSHR-------HSSASSANI 1059
            :|    :|.|::.|..|.       |.:..|.||
plant   710 RRFQIAVGTAKALSFLHNDCKPAILHLNVKSTNI 743

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LrrkNP_001262772.1 Ank_2 111..200 CDD:289560
ANK 146..286 CDD:238125
ANK repeat 146..177 CDD:293786
Ank_4 179..232 CDD:290365
ANK repeat 179..209 CDD:293786
Ank_2 216..389 CDD:289560
ANK 361..477 CDD:238125
ANK repeat 361..390 CDD:293786
Ank_2 364..464 CDD:289560
ANK repeat 406..435 CDD:293786
ANK repeat 437..464 CDD:293786
LRR_8 <544..580 CDD:290566 8/52 (15%)
leucine-rich repeat 547..569 CDD:275380 3/22 (14%)
LRR_8 569..629 CDD:290566 19/61 (31%)
leucine-rich repeat 570..595 CDD:275380 8/25 (32%)
leucine-rich repeat 596..618 CDD:275380 7/22 (32%)
leucine-rich repeat 619..641 CDD:275380 6/22 (27%)
leucine-rich repeat 642..676 CDD:275380 9/37 (24%)
leucine-rich repeat 677..730 CDD:275380 9/69 (13%)
LRR_8 729..788 CDD:290566 19/59 (32%)
leucine-rich repeat 731..754 CDD:275380 7/23 (30%)
LRR_8 855..933 CDD:290566 19/111 (17%)
leucine-rich repeat 855..901 CDD:275380 11/79 (14%)
leucine-rich repeat 902..924 CDD:275380 5/21 (24%)
leucine-rich repeat 925..949 CDD:275380 4/23 (17%)
P-loop_NTPase 993..1211 CDD:304359 18/78 (23%)
COR 1230..1471 CDD:292713
STYKc 1796..2092 CDD:214568
STKc_LRRK 1801..2095 CDD:270902
AT1G62950NP_176483.1 PLN00113 6..882 CDD:215061 137/684 (20%)
leucine-rich repeat 99..122 CDD:275380
leucine-rich repeat 123..146 CDD:275380
leucine-rich repeat 147..171 CDD:275380 3/15 (20%)
leucine-rich repeat 172..195 CDD:275380 3/22 (14%)
leucine-rich repeat 196..218 CDD:275380 3/21 (14%)
leucine-rich repeat 219..242 CDD:275380 2/22 (9%)
leucine-rich repeat 243..266 CDD:275380 3/22 (14%)
leucine-rich repeat 267..290 CDD:275380 8/25 (32%)
leucine-rich repeat 291..314 CDD:275380 7/22 (32%)
leucine-rich repeat 315..338 CDD:275380 6/22 (27%)
leucine-rich repeat 339..362 CDD:275380 4/24 (17%)
leucine-rich repeat 363..386 CDD:275380 6/28 (21%)
leucine-rich repeat 387..410 CDD:275380 3/28 (11%)
leucine-rich repeat 411..434 CDD:275380 3/22 (14%)
leucine-rich repeat 435..458 CDD:275380 7/23 (30%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 138 1.000 Inparanoid score I1805
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
11.050

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