DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lrrk and AT1G53420

DIOPT Version :9

Sequence 1:	NP_001262772.1	Gene:	Lrrk / 42447	FlyBaseID:	FBgn0038816	Length:	2513	Species:	Drosophila melanogaster
Sequence 2:	NP_175747.2	Gene:	AT1G53420 / 841777	AraportID:	AT1G53420	Length:	953	Species:	Arabidopsis thaliana

Alignment Length:	1076	Identity:	196/1076 - (18%)
Similarity:	356/1076 - (33%)	Gaps:	326/1076 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly  1133 NIQARAPNSPVIIVGTHFDAVGESISPQKAEQLQQLIREKFIAIPDAEKIGLPR--VIDSI--EI 1193
            ||........|...|..:..:..::   |.|.||..:.::.:.:|..::|.|.|  :..||  |.
plant    46 NIDLNVDPCEVSSTGNEWSTISRNL---KRENLQGSLPKELVGLPLLQEIDLSRNYLNGSIPPEW 107

  Fly  1194 SCRTLHNIHLLANIIYDTAMQLRSPGSKEPMLLQKIPASYIALEDIVNVIACNLRAAGRDPVLDG 1258
            ....|.||.||.|       :|..|          ||..:..:..:.:::....:.:|..|:
plant   108 GVLPLVNIWLLGN-------RLTGP----------IPKEFGNITTLTSLVLEANQLSGELPL--- 152

  Fly  1259 EQYKRLVTEQMRLHNYKSFRDA-----AELQQATTWCHENGVLLHYDDATLRDYYFLDPQWLCDM 1318
             :...|...|..:.:..:|...     |:|                  .||||:...|.|
plant   153 -ELGNLPNIQQMILSSNNFNGEIPSTFAKL------------------TTLRDFRVSDNQ----- 193

  Fly  1319 LAHVVTVREINPFAPTGVMKLDDLQMLFRSVQVQGNGNRSYIVSLLNKFEVALTWDSRTLLIPSL 1383
                     ::...|..:.|...|:.||    :|.:|       |:....:|         |.||
plant   194 ---------LSGTIPDFIQKWTKLERLF----IQASG-------LVGPIPIA---------IASL 229

  Fly  1384 LPSQEAATPNSGSTVKLSQRSRGRSLGCSVSQEVNLNNLIYEQRSAPSSSSSSASVSQGLRRILL 1448
                                             |.|.:|.....:.|.|........:.:..::|
plant   230 ---------------------------------VELKDLRISDLNGPESPFPQLRNIKKMETLIL 261

  Fly  1449 MTYFPSGFWSRLITRI-------LADEQIIEAIRGVYMASQD--------------YADFDLRTS 1492
            .....:|.....:.:|       |:..::..||...|:..:|              ..|:.:...
plant   262 RNCNLTGDLPDYLGKITSFKFLDLSFNKLSGAIPNTYINLRDGGYIYFTGNMLNGSVPDWMVNKG 326

  Fly  1493 LEQDTQWNLWQ---TGLALYYGPIL-IFKIWEVPFQKTERTQPFRTDGNRFKLKQDGIWSDVNLS 1553
            .:.|..:|.:.   |.....|..:| ..:.::.|  ||.........|:...:......||....
plant   327 YKIDLSYNNFSVDPTNAVCKYNNVLSCMRNYQCP--KTFNALHINCGGDEMSINGTIYESDKYDR 389

  Fly  1554 SSSILEVYFPLYEVNISQEVDDNERQLLAEIRPHMSQV----------AKLLALTVDHIDLLLED 1608
            ..|..|.....:..|:...|||........|..:.|::          |::.|:::.:..|.||:
plant   390 LESWYESRNGWFSNNVGVFVDDKHVPERVTIESNSSELNVVDFGLYTQARISAISLTYYALCLEN 454

  Fly  1609 W------------------YPSLGTRFVHTSEGRFLITRLVLCPRCLWKLQLQQNNEPSDREVPP 1655
            .                  |.|||.||                    :.:.:|:..|..|..:
plant   455 GNYNVNLHFAEIMFNGNNNYQSLGRRF--------------------FDIYIQRKLEVKDFNI-- 497

  Fly  1656 VGCNRPSRSSRRGAGAYFLHGVGDPGEDGALNV--FSAYLNATARRERRSEDSLGAGSDADSGVG 1718
                   ....:..|...:.......:||.|.:  :.|....|...:.|....|.:....||.|.
plant   498 -------AKEAKDVGNVVIKTFPVEIKDGKLEIRLYWAGRGTTVIPKERVYGPLISAISVDSSVN 555

  Fly  1719 PDSAGSSRNTSVDGHPGYHLPDNSNVCYAWMIEECILSVY----------NQSKISCPVHLEQSM 1773
            |    |.||....|           ..:..::   |||::          .:..:.....:|:..
plant   556 P----SPRNGMSTG-----------TLHTLVV---ILSIFIVFLVFGTLWKKGYLRSKSQMEKDF 602

  Fly  1774 AQLAPDVIFADIPDKH-TIPSECIIKGSLLGRGAFGFVFKANCKVRGARSFKP--VAMKMLQPVP 1835
            ..|  :::.|....:. .|.:......:.:|.|.||.|:|       .:.|..  :|:|.|.
plant   603 KSL--ELMIASFSLRQIKIATNNFDSANRIGEGGFGPVYK-------GKLFDGTIIAVKQLS--- 655

  Fly  1836 PGARAKESALMAFKVAVGKWDRDPLQHSCKAYCTARQELAVLLTLKHPNIVPLVGICIK--PLAL 1898
            .|::              :.:|:.|           .|:.::..|.|||:|.|.|.|::  .|.|
plant   656 TGSK--------------QGNREFL-----------NEIGMISALHHPNLVKLYGCCVEGGQLLL 695

  Fly  1899 VLELAPLGGLDALLRHYRRSGAHMGPHTFQTLVLQAARAIEYLH---RRRIIYRDLKSENVLVWE 1960
            |.|......|...|...:.:...:...|.:.:.:..||.:.|||   |.:|::||:|:.|||:.:
plant   696 VYEFVENNSLARALFGPQETQLRLDWPTRRKICIGVARGLAYLHEESRLKIVHRDIKATNVLLDK 760

  Fly  1961 LPQPHTEDSPRNLVHIKIADYGISR---QTAPSGAKGFGGTEGFMAPEIIRYNGEEEYTEKVDCF 2022
            ...|            ||:|:|:::   :.:...:....||.|:||||   |......|:|.|.:
plant   761 QLNP------------KISDFGLAKLDEEDSTHISTRIAGTFGYMAPE---YAMRGHLTDKADVY 810

  Fly  2023 SFGMFIYENIS----------------------LRQPFEGHESIKECILEGSRPAL-TQRETQFP 2064
            |||:...|.:.                      ||:        |..:||...|.| ::...:..
plant   811 SFGIVALEIVHGRSNKIERSKNNTFYLIDWVEVLRE--------KNNLLELVDPRLGSEYNREEA 867

  Fly  2065 TCCLDLMVLCWHEQPRRRPTASQIVSILSAPECIHL 2100
            ...:.:.::|...:|..||:.|::|.:|...:.:.:
plant   868 MTMIQIAIMCTSSEPCERPSMSEVVKMLEGKKMVEV 903

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lrrk	NP_001262772.1	Ank_2	111..200	CDD:289560
		ANK	146..286	CDD:238125
		ANK repeat	146..177	CDD:293786
		Ank_4	179..232	CDD:290365
		ANK repeat	179..209	CDD:293786
		Ank_2	216..389	CDD:289560
		ANK	361..477	CDD:238125
		ANK repeat	361..390	CDD:293786
		Ank_2	364..464	CDD:289560
		ANK repeat	406..435	CDD:293786
		ANK repeat	437..464	CDD:293786
		LRR_8	<544..580	CDD:290566
		leucine-rich repeat	547..569	CDD:275380
		LRR_8	569..629	CDD:290566
		leucine-rich repeat	570..595	CDD:275380
		leucine-rich repeat	596..618	CDD:275380
		leucine-rich repeat	619..641	CDD:275380
		leucine-rich repeat	642..676	CDD:275380
		leucine-rich repeat	677..730	CDD:275380
		LRR_8	729..788	CDD:290566
		leucine-rich repeat	731..754	CDD:275380
		LRR_8	855..933	CDD:290566
		leucine-rich repeat	855..901	CDD:275380
		leucine-rich repeat	902..924	CDD:275380
		leucine-rich repeat	925..949	CDD:275380
		P-loop_NTPase	993..1211	CDD:304359	21/81 (26%)
		COR	1230..1471	CDD:292713	35/252 (14%)
		STYKc	1796..2092	CDD:214568	75/328 (23%)
		STKc_LRRK	1801..2095	CDD:270902	76/326 (23%)
AT1G53420	NP_175747.2	leucine-rich repeat	89..110	CDD:275380	6/20 (30%)
		leucine-rich repeat	112..135	CDD:275380	10/39 (26%)
		leucine-rich repeat	136..159	CDD:275380	3/26 (12%)
		leucine-rich repeat	160..183	CDD:275380	4/40 (10%)
		leucine-rich repeat	184..207	CDD:275380	7/36 (19%)
		leucine-rich repeat	208..231	CDD:275380	10/75 (13%)
		leucine-rich repeat	232..255	CDD:275380	4/22 (18%)
		leucine-rich repeat	256..279	CDD:275380	3/22 (14%)
		leucine-rich repeat	280..301	CDD:275380	4/20 (20%)
		leucine-rich repeat	304..325	CDD:275380	1/20 (5%)
		leucine-rich repeat	327..345	CDD:275380	3/17 (18%)
		Malectin	366..548	CDD:288557	33/210 (16%)
		STKc_IRAK	630..897	CDD:270968	76/324 (23%)
		TyrKc	630..895	CDD:197581	75/322 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	138	1.000	Inparanoid score	I1805
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.050