DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lrrk and AT1G34420

DIOPT Version :9

Sequence 1:	NP_001262772.1	Gene:	Lrrk / 42447	FlyBaseID:	FBgn0038816	Length:	2513	Species:	Drosophila melanogaster
Sequence 2:	NP_174702.1	Gene:	AT1G34420 / 840345	AraportID:	AT1G34420	Length:	966	Species:	Arabidopsis thaliana

Alignment Length:	555	Identity:	142/555 - (25%)
Similarity:	208/555 - (37%)	Gaps:	181/555 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   465 SDYKINKKGLPTPVEVNVFLPSTSNISYSAMFPNNPTIIDWHSMGSSVQLSVVRVPWMVSGVL-- 527
            |:..:|:..  |.:|::.||    |||            ||:..||.      |.|...:|||
plant    37 SELSLNQTN--TMIELSSFL----NIS------------DWNLPGSE------RNPCSWNGVLCS 77

  Fly   528 -----------LLNPKLQSHPRLNEVA-LTAITRIDFSHNVLTSIPQELF----HLVSLRYLNVA 576
                       |.|..|.:...|..|. |..:..:|.|:|.|:|||:...    .|::|::||.:
plant    78 LPDNSSVISLSLSNFDLSNSSFLPLVCNLQTLESLDVSNNRLSSIPEGFVTNCERLIALKHLNFS 142

  Fly   577 QNKITDLPAPIGQTYGCPVLDELFLQDNQLTTLPAAIFHLPALSILDVSNNKLQ----QLPFDLW 637
            .||.:..|...|                           ...|::||.|:|.|.    ...||
plant   143 TNKFSTSPGFRG---------------------------FSKLAVLDFSHNVLSGNVGDYGFD-- 178

  Fly   638 RAPKLRELNVAFNLLRDLPVPPMQTSSSLLSLDKLNLQSFEEPPSNKPRNVTQ-QRLTHRNLWSA 701
            ...:||.||::||.|.. .||...|.    ||:||.: |........|..:.. |.||
plant   179 GLVQLRSLNLSFNRLTG-SVPVHLTK----SLEKLEV-SDNSLSGTIPEGIKDYQELT------- 230

  Fly   702 TLDITDNDMKWQHEQDLGDGKTAGVGSSQLSSLNIANNLFTS-IPAALPC--------------- 750
            .:|::||.:.......||:       .|:|.||.::||..:. ||.:|..
plant   231 LIDLSDNQLNGSIPSSLGN-------LSKLESLLLSNNYLSGLIPESLSSIQTLRRFAANRNRFT 288

  Fly   751 ------LAVNLTRLNMSYNSLRSMGHVTSYPA-TLKQL-----DLSHNEISCWPSLPRITESDPH 803
                  |..:|..|::|:|||..     |.|. .|.||     |||.|::..|  :|:...|
plant   289 GEIPSGLTKHLENLDLSFNSLAG-----SIPGDLLSQLKLVSVDLSSNQLVGW--IPQSISS--- 343

  Fly   804 LLCYSCVQLPEGRDDDYKTASSKGSSSSATSFRASVLKSVCRHRRHLRLEALRTLILADNLLTRI 868
                |.|:|..|             |:..|....||           ..|:|:       |||.:
plant   344 ----SLVRLRLG-------------SNKLTGSVPSV-----------AFESLQ-------LLTYL 373

  Fly   869 QLSTDDATTL----FNESEDADWSVVGVNRSKVIFP----NLSMLDM----TNNCLKEIPASLHE 921
            ::..:..|..    |......:...:.:|....|.|    |||.|.:    .|....|||.::..
plant   374 EMDNNSLTGFIPPSFGNLVSLNLLNLAMNEFTGILPPAFGNLSRLQVIKLQQNKLTGEIPDTIAF 438

  Fly   922 LSSLSVLNISGNVNITELPPHLGLLSRLWNLNTRG 956
            ||:|.:||||.|.....:||.|..|.||.|:|.:|
plant   439 LSNLLILNISCNSLSGSIPPSLSQLKRLSNMNLQG 473

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lrrk	NP_001262772.1	Ank_2	111..200	CDD:289560
		ANK	146..286	CDD:238125
		ANK repeat	146..177	CDD:293786
		Ank_4	179..232	CDD:290365
		ANK repeat	179..209	CDD:293786
		Ank_2	216..389	CDD:289560
		ANK	361..477	CDD:238125	2/11 (18%)
		ANK repeat	361..390	CDD:293786
		Ank_2	364..464	CDD:289560
		ANK repeat	406..435	CDD:293786
		ANK repeat	437..464	CDD:293786
		LRR_8	<544..580	CDD:290566	13/39 (33%)
		leucine-rich repeat	547..569	CDD:275380	8/25 (32%)
		LRR_8	569..629	CDD:290566	12/59 (20%)
		leucine-rich repeat	570..595	CDD:275380	7/24 (29%)
		leucine-rich repeat	596..618	CDD:275380	0/21 (0%)
		leucine-rich repeat	619..641	CDD:275380	8/25 (32%)
		leucine-rich repeat	642..676	CDD:275380	14/33 (42%)
		leucine-rich repeat	677..730	CDD:275380	9/53 (17%)
		LRR_8	729..788	CDD:290566	25/86 (29%)
		leucine-rich repeat	731..754	CDD:275380	9/44 (20%)
		LRR_8	855..933	CDD:290566	24/89 (27%)
		leucine-rich repeat	855..901	CDD:275380	9/53 (17%)
		leucine-rich repeat	902..924	CDD:275380	8/25 (32%)
		leucine-rich repeat	925..949	CDD:275380	10/23 (43%)
		P-loop_NTPase	993..1211	CDD:304359
		COR	1230..1471	CDD:292713
		STYKc	1796..2092	CDD:214568
		STKc_LRRK	1801..2095	CDD:270902
AT1G34420	NP_174702.1	PLN00113	12..963	CDD:215061	142/555 (26%)
		leucine-rich repeat	109..135	CDD:275380	8/25 (32%)
		leucine-rich repeat	136..157	CDD:275380	7/47 (15%)
		leucine-rich repeat	158..182	CDD:275380	8/25 (32%)
		leucine-rich repeat	183..204	CDD:275380	10/25 (40%)
		leucine-rich repeat	205..228	CDD:275380	5/23 (22%)
		leucine-rich repeat	229..276	CDD:275380	16/60 (27%)
		leucine-rich repeat	299..319	CDD:275380	8/24 (33%)
		leucine-rich repeat	323..344	CDD:275380	7/29 (24%)
		leucine-rich repeat	345..369	CDD:275380	9/54 (17%)
		leucine-rich repeat	370..393	CDD:275380	4/22 (18%)
		leucine-rich repeat	394..417	CDD:275380	5/22 (23%)
		leucine-rich repeat	418..441	CDD:275380	6/22 (27%)
		leucine-rich repeat	442..465	CDD:275380	10/22 (45%)
		leucine-rich repeat	466..489	CDD:275380	4/8 (50%)
		leucine-rich repeat	490..511	CDD:275380
		leucine-rich repeat	513..535	CDD:275380
		leucine-rich repeat	536..559	CDD:275380
		STKc_IRAK	694..966	CDD:270968
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	138	1.000	Inparanoid score	I1805
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.050