DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lrrk and PEPR2

DIOPT Version :9

Sequence 1:	NP_001262772.1	Gene:	Lrrk / 42447	FlyBaseID:	FBgn0038816	Length:	2513	Species:	Drosophila melanogaster
Sequence 2:	NP_173217.1	Gene:	PEPR2 / 838353	AraportID:	AT1G17750	Length:	1088	Species:	Arabidopsis thaliana

Alignment Length:	1042	Identity:	221/1042 - (21%)
Similarity:	358/1042 - (34%)	Gaps:	338/1042 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   479 EVNVFLPSTSNI--SYSAMFPNNPTIIDWHSMGSSVQLSVVRVPWMVSGVLLLN-------PKLQ 534
            ::|..||::..:  :...:|.:|      :|:|..:.........:||..|..|       |::.
plant   207 KLNGSLPASLYLLENLGELFVSN------NSLGGRLHFGSSNCKKLVSLDLSFNDFQGGVPPEIG 265

  Fly   535 SHPRLNEVALTAITRIDFSHNVLTSIPQELFHLVSLRYLNVAQNKIT-DLPAPIGQTYGCPVLDE 598
            :...|:.:.:...       |:..:||..:..|..:..::::.|::: ::|..:|   .|..|:.
plant   266 NCSSLHSLVMVKC-------NLTGTIPSSMGMLRKVSVIDLSDNRLSGNIPQELG---NCSSLET 320

  Fly   599 LFLQDNQLT-TLPAAIFHLPALSILDVSNNKLQ-QLPFDLWRAPKLRELNVAFNLLR-DLPVPPM 660
            |.|.||||. .:|.|:..|..|..|::..|||. ::|..:|:...|.::.|..|.|. :|||...
plant   321 LKLNDNQLQGEIPPALSKLKKLQSLELFFNKLSGEIPIGIWKIQSLTQMLVYNNTLTGELPVEVT 385

  Fly   661 QTSSSLLSLDKLNL----------------QSFEEPP--SNKPRNVTQQRLTH----------RN 697
            |    |..|.||.|                :|.||..  .|:........|.|          .|
plant   386 Q----LKHLKKLTLFNNGFYGDIPMSLGLNRSLEEVDLLGNRFTGEIPPHLCHGQKLRLFILGSN 446

  Fly   698 LWSATLDITDNDMKWQHEQDLGDGKTAGV-----GSSQLSSLNIANNLFT-SIPAAL-PCLAVNL 755
            .....:..:....|......|.|.|.:||     .|..||.:|:.:|.|. |||.:| .|  .||
plant   447 QLHGKIPASIRQCKTLERVRLEDNKLSGVLPEFPESLSLSYVNLGSNSFEGSIPRSLGSC--KNL 509

  Fly   756 TRLNMSYNSLR-----SMGHVTSYPATLKQLDLSHNEISCWPSLPRITESDPHLLCYSCVQLPEG 815
            ..:::|.|.|.     .:|::.|    |..|:||||.:.  ..||........||.:
plant   510 LTIDLSQNKLTGLIPPELGNLQS----LGLLNLSHNYLE--GPLPSQLSGCARLLYF-------- 560

  Fly   816 RDDDYKTASSKGSSSSATSFRASVLKSVCRHRRHLRLEALRTLILADNLLTRIQLSTDDATTLFN 880
               |..:.|..||..|  |||:              .::|.||:|:||
plant   561 ---DVGSNSLNGSIPS--SFRS--------------WKSLSTLVLSDN----------------- 589

  Fly   881 ESEDADWSVVG-VNRSKVIFPNLSMLDMTNNCL-KEIPASLHELSSLSV-LNISGNVNITELPPH 942
                   :.:| :.:.......||.|.:..|.. .:||:|:..|.||.. |::|.||...|:|..
plant   590 -------NFLGAIPQFLAELDRLSDLRIARNAFGGKIPSSVGLLKSLRYGLDLSANVFTGEIPTT 647

  Fly   943 LGLLSRLWNLNTRGCLLQEPLRSMIESKKHKTMDIVGYLK-------SIYEDAQPYARMKLMVVG 1000
            ||.|..|..||.....|..|| |:::|.|......|.|.:       ::..::..::
plant   648 LGALINLERLNISNNKLTGPL-SVLQSLKSLNQVDVSYNQFTGPIPVNLLSNSSKFS-------- 703

  Fly  1001 VAGIGKSTLLDLLRQGAGSGSS-----SSSHRSRASENHWAKRMGHARST--------------S 1046
                |..   ||..|.:.|.|:     ..|.:.:...:.|...:..|.|:              .
plant   704 ----GNP---DLCIQASYSVSAIIRKEFKSCKGQVKLSTWKIALIAAGSSLSVLALLFALFLVLC 761

  Fly  1047 RSHRHSSASSANI---------------STVGVDIGTWICEKRKRAPGSHGPVVFRTWDFGGQKE 1096
            |..|.:....|||               :|..:|      :|.....|:|| ||:|. ..|..:|
plant   762 RCKRGTKTEDANILAEEGLSLLLNKVLAATDNLD------DKYIIGRGAHG-VVYRA-SLGSGEE 818

  Fly  1097 Y------YATH--------------------------QYFLSKR------------SLYLVLWRI 1117
            |      :|.|                          ::::.|.            ||:.||.|
plant   819 YAVKKLIFAEHIRANQNMKREIETIGLVRHRNLIRLERFWMRKEDGLMLYQYMPNGSLHDVLHR- 882

  Fly  1118 SDGHKGLAELLQWLGNIQARAPNSPVIIVG-------THFDA----VGESISPQKAEQLQQLIRE 1171
              |::|.| :|.|.....        |.:|       .|.|.    :...|.|           |
plant   883 --GNQGEA-VLDWSARFN--------IALGISHGLAYLHHDCHPPIIHRDIKP-----------E 925

  Fly  1172 KFIAIPDAE----KIGLPRVIDSIEISCRTLHNIHLLANIIYDTAMQLRSPGSKEPMLLQKIPAS 1232
            ..:...|.|    ..||.|::|...:|..|:..                             ...
plant   926 NILMDSDMEPHIGDFGLARILDDSTVSTATVTG-----------------------------TTG 961

  Fly  1233 YIALEDIVNVIACNLRAAGRDPVLDGEQYKRLVTEQMRLHNYKSFRDAAELQQATTWCHENGVLL 1297
            |||.|:....:    |:...|....|.....|||.:..|.  :||.:...:   .:|.  ..||.
plant   962 YIAPENAYKTV----RSKESDVYSYGVVLLELVTGKRALD--RSFPEDINI---VSWV--RSVLS 1015

  Fly  1298 HYDDATLRDYYFLDPQWLCDML-----AHVVTVREI-----------NPFAPTGVMKLDDLQMLF 1346
            .|:|........:||:.:.::|     ...:.|.::           .|.....|..|.||:...
plant  1016 SYEDEDDTAGPIVDPKLVDELLDTKLREQAIQVTDLALRCTDKRPENRPSMRDVVKDLTDLESFV 1080

  Fly  1347 RS 1348
            ||
plant  1081 RS 1082

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lrrk	NP_001262772.1	Ank_2	111..200	CDD:289560
		ANK	146..286	CDD:238125
		ANK repeat	146..177	CDD:293786
		Ank_4	179..232	CDD:290365
		ANK repeat	179..209	CDD:293786
		Ank_2	216..389	CDD:289560
		ANK	361..477	CDD:238125
		ANK repeat	361..390	CDD:293786
		Ank_2	364..464	CDD:289560
		ANK repeat	406..435	CDD:293786
		ANK repeat	437..464	CDD:293786
		LRR_8	<544..580	CDD:290566	5/35 (14%)
		leucine-rich repeat	547..569	CDD:275380	4/21 (19%)
		LRR_8	569..629	CDD:290566	17/61 (28%)
		leucine-rich repeat	570..595	CDD:275380	4/25 (16%)
		leucine-rich repeat	596..618	CDD:275380	10/22 (45%)
		leucine-rich repeat	619..641	CDD:275380	7/22 (32%)
		leucine-rich repeat	642..676	CDD:275380	13/50 (26%)
		leucine-rich repeat	677..730	CDD:275380	13/69 (19%)
		LRR_8	729..788	CDD:290566	23/65 (35%)
		leucine-rich repeat	731..754	CDD:275380	10/24 (42%)
		LRR_8	855..933	CDD:290566	19/80 (24%)
		leucine-rich repeat	855..901	CDD:275380	7/46 (15%)
		leucine-rich repeat	902..924	CDD:275380	8/22 (36%)
		leucine-rich repeat	925..949	CDD:275380	10/24 (42%)
		P-loop_NTPase	993..1211	CDD:304359	55/310 (18%)
		COR	1230..1471	CDD:292713	29/135 (21%)
		STYKc	1796..2092	CDD:214568
		STKc_LRRK	1801..2095	CDD:270902
PEPR2	NP_173217.1	PLN00113	9..1087	CDD:215061	221/1042 (21%)
		leucine-rich repeat	79..98	CDD:275380
		leucine-rich repeat	102..125	CDD:275380
		leucine-rich repeat	126..149	CDD:275380
		leucine-rich repeat	150..173	CDD:275380
		leucine-rich repeat	174..197	CDD:275380
		leucine-rich repeat	198..221	CDD:275380	3/13 (23%)
		leucine-rich repeat	222..245	CDD:275380	4/28 (14%)
		leucine-rich repeat	246..269	CDD:275380	5/22 (23%)
		leucine-rich repeat	270..317	CDD:275380	9/56 (16%)
		leucine-rich repeat	274..293	CDD:275380	4/25 (16%)
		leucine-rich repeat	318..339	CDD:275380	9/20 (45%)
		leucine-rich repeat	342..365	CDD:275380	7/22 (32%)
		leucine-rich repeat	366..389	CDD:275380	9/26 (35%)
		leucine-rich repeat	390..413	CDD:275380	4/22 (18%)
		leucine-rich repeat	414..437	CDD:275380	5/22 (23%)
		leucine-rich repeat	462..484	CDD:275380	6/21 (29%)
		leucine-rich repeat	485..508	CDD:275380	10/24 (42%)
		leucine-rich repeat	509..532	CDD:275380	5/22 (23%)
		leucine-rich repeat	533..556	CDD:275380	8/24 (33%)
		leucine-rich repeat	557..580	CDD:275380	10/49 (20%)
		leucine-rich repeat	581..628	CDD:275380	15/70 (21%)
		leucine-rich repeat	629..653	CDD:275380	10/23 (43%)
		leucine-rich repeat	654..676	CDD:275380	8/22 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	138	1.000	Inparanoid score	I1805
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.960