DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lrrk and AT1G17230

DIOPT Version :9

Sequence 1:	NP_001262772.1	Gene:	Lrrk / 42447	FlyBaseID:	FBgn0038816	Length:	2513	Species:	Drosophila melanogaster
Sequence 2:	NP_001322898.1	Gene:	AT1G17230 / 838294	AraportID:	AT1G17230	Length:	1133	Species:	Arabidopsis thaliana

Alignment Length:	1184	Identity:	269/1184 - (22%)
Similarity:	406/1184 - (34%)	Gaps:	447/1184 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   221 INGHIKLLELLISYSYPDYLYQTYRDEEGQ------------------WEWRLPFDANAHDVTGQ 267
            :.|.|..|.::|..|:...|.::. :|||:                  |.   ..|:|..:.||.
plant     1 MRGRICFLAIVILCSFSFILVRSL-NEEGRVLLEFKAFLNDSNGYLASWN---QLDSNPCNWTGI 61

  Fly   268 TSLYIASI----LGNKQLVGVL--LKWQLHCRRTLGDSASSVSTPITPTRKRISFGIQAIMSKLH 326
            ...::.::    |....|.|.|  |..:||..|.|..|.:.:|.||
plant    62 ACTHLRTVTSVDLNGMNLSGTLSPLICKLHGLRKLNVSTNFISGPI------------------- 107

  Fly   327 ISGESEGPDDLASQESTE----CQR-----CPINVNL--------LCGAARETALLAAV--RGGH 372
                   |.||:...|.|    |..     .||.:.:        ||    |..|..::  :.|:
plant   108 -------PQDLSLCRSLEVLDLCTNRFHGVIPIQLTMIITLKKLYLC----ENYLFGSIPRQIGN 161

  Fly   373 LDVVQSLLQHGANPNIVAKPVEDHNDPKCCEEIYGLSNVPIAEACKQRSLAMLDLLLKHGARDDN 437
            |..:|.|:.:..|                      |:.|......|.|.|.    :::.|....:
plant   162 LSSLQELVIYSNN----------------------LTGVIPPSMAKLRQLR----IIRAGRNGFS 200

  Fly   438 GTAIGMAITCGDEAILSRLLARRVHPDSDYKINKKGLPTPVE-----VNVFL----------PST 487
            |........|....:|.  ||..:...|        ||..:|     .::.|          ||.
plant   201 GVIPSEISGCESLKVLG--LAENLLEGS--------LPKQLEKLQNLTDLILWQNRLSGEIPPSV 255

  Fly   488 SNIS---YSAMFPNNPTIIDWHSMGSSVQLSVVRVPWMVSGVLLLNPKLQSHPRLNEVA-LTAIT 548
            .|||   ..|:..|..|        .|:...:.::..|....|..|......||  |:. |....
plant   256 GNISRLEVLALHENYFT--------GSIPREIGKLTKMKRLYLYTNQLTGEIPR--EIGNLIDAA 310

  Fly   549 RIDFSHNVLTS-IPQELFHLVSLRYLNVAQN-KITDLPAPIGQTYGCPVLDELFLQDNQLT-TLP 610
            .||||.|.||. ||:|..|:::|:.|::.:| .:..:|..:|:   ..:|::|.|..|:|. |:|
plant   311 EIDFSENQLTGFIPKEFGHILNLKLLHLFENILLGPIPRELGE---LTLLEKLDLSINRLNGTIP 372

  Fly   611 AAIFHLPAL------------------------SILDVSNNKLQ-QLPFDLWRAPKLRELNVAFN 650
            ..:..||.|                        |:||:|.|.|. .:|....|...|..|::..|
plant   373 QELQFLPYLVDLQLFDNQLEGKIPPLIGFYSNFSVLDMSANSLSGPIPAHFCRFQTLILLSLGSN 437

  Fly   651 LL-----RDLPVPPMQTSSSL-------------LSLDKLNLQSFEEPPSNKPRNVTQQRLTHRN 697
            .|     |||     :|..||             |.::..|||           |:|...| |:|
plant   438 KLSGNIPRDL-----KTCKSLTKLMLGDNQLTGSLPIELFNLQ-----------NLTALEL-HQN 485

  Fly   698 LWSATLDITDNDMKWQHEQDLGDGKTAGVGSSQLSSLNIANNLFT-SIPAALPCLAVNLTRL--- 758
            ..|..:           ..|||..|       .|..|.:|||.|| .||..:.    |||::
plant   486 WLSGNI-----------SADLGKLK-------NLERLRLANNNFTGEIPPEIG----NLTKIVGF 528

  Fly   759 NMSYNSLRSMGHVTSYP------ATLKQLDLSHNEISCWPSLPRITESDPHLLCYSCVQLPEGRD 817
            |:|.|.|  .||:   |      .|:::||||.|:.|.:     |.:....|:....::|.:.|
plant   529 NISSNQL--TGHI---PKELGSCVTIQRLDLSGNKFSGY-----IAQELGQLVYLEILRLSDNR- 582

  Fly   818 DDYKTASSKGSSSSATSFRASVLKSVCRHRRHLRLEALRTLILADNL------LTRIQLSTDDAT 876
               .|.....|....|              |.:.|: |...:|::|:      ||.:|:|
plant   583 ---LTGEIPHSFGDLT--------------RLMELQ-LGGNLLSENIPVELGKLTSLQIS----- 624

  Fly   877 TLFNESEDADWSVVGVNRSKVI---FPNLSMLDM----TNNCLKEIPASLHELSSLSVLNISGNV 934
              .|.|.:        |.|..|   ..||.||::    .|....|||||:..|.||.:.|||.|
plant   625 --LNISHN--------NLSGTIPDSLGNLQMLEILYLNDNKLSGEIPASIGNLMSLLICNISNN- 678

  Fly   935 NITELPPHLGLLSRLWNLNTRG----CLLQ----EPLRSMIESKKHKTMDIVGYLKSIYEDAQPY 991
            |:....|...:..|:.:.|..|    |..|    :||....:||          |..:...:|
plant   679 NLVGTVPDTAVFQRMDSSNFAGNHGLCNSQRSHCQPLVPHSDSK----------LNWLINGSQ-- 731

  Fly   992 ARMKLMVVGVAGIGKSTLLDLL--------RQGA------------------------------- 1017
             |.|::.:....||...|:..|        |:.|
plant   732 -RQKILTITCIVIGSVFLITFLGLCWTIKRREPAFVALEDQTKPDVMDSYYFPKKGFTYQGLVDA 795

  Fly  1018 ----------GSGSSSSSHRSRAS--ENHWAKRM---GHARSTSRSHRHSSASSANISTVGVDIG 1067
                      |.|:..:.:::..|  |....|::   |...|:..|.|      |.|||:|
plant   796 TRNFSEDVVLGRGACGTVYKAEMSGGEVIAVKKLNSRGEGASSDNSFR------AEISTLG---- 850

  Fly  1068 TWICEKRKRAPGSHGPVVFRTWDFGGQKEY-YATHQ-------YFLSKRSLYLVLWRISDGHKGL 1124
                  :.|    |..:|         |.| :..||       .::||.||...|.|   |.|..
plant   851 ------KIR----HRNIV---------KLYGFCYHQNSNLLLYEYMSKGSLGEQLQR---GEKNC 893

  Fly  1125 AELLQWLGNIQARAPNSPVIIVGT-------HFDAVGESISPQ------KAEQLQQLIREKFIA- 1175
              ||.|  |.:.|      |.:|.       |.|.     .||      |:..:  |:.|:|.|
plant   894 --LLDW--NARYR------IALGAAEGLCYLHHDC-----RPQIVHRDIKSNNI--LLDERFQAH 941

  Fly  1176 IPDAEKIGLPRVID 1189
            :.|   .||.::||
plant   942 VGD---FGLAKLID 952

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lrrk	NP_001262772.1	Ank_2	111..200	CDD:289560
		ANK	146..286	CDD:238125	18/88 (20%)
		ANK repeat	146..177	CDD:293786
		Ank_4	179..232	CDD:290365	3/10 (30%)
		ANK repeat	179..209	CDD:293786
		Ank_2	216..389	CDD:289560	44/210 (21%)
		ANK	361..477	CDD:238125	21/117 (18%)
		ANK repeat	361..390	CDD:293786	7/30 (23%)
		Ank_2	364..464	CDD:289560	17/101 (17%)
		ANK repeat	406..435	CDD:293786	6/28 (21%)
		ANK repeat	437..464	CDD:293786	5/26 (19%)
		LRR_8	<544..580	CDD:290566	15/37 (41%)
		leucine-rich repeat	547..569	CDD:275380	11/22 (50%)
		LRR_8	569..629	CDD:290566	20/85 (24%)
		leucine-rich repeat	570..595	CDD:275380	5/25 (20%)
		leucine-rich repeat	596..618	CDD:275380	8/22 (36%)
		leucine-rich repeat	619..641	CDD:275380	9/46 (20%)
		leucine-rich repeat	642..676	CDD:275380	13/51 (25%)
		leucine-rich repeat	677..730	CDD:275380	10/52 (19%)
		LRR_8	729..788	CDD:290566	25/68 (37%)
		leucine-rich repeat	731..754	CDD:275380	9/23 (39%)
		LRR_8	855..933	CDD:290566	28/90 (31%)
		leucine-rich repeat	855..901	CDD:275380	12/54 (22%)
		leucine-rich repeat	902..924	CDD:275380	10/25 (40%)
		leucine-rich repeat	925..949	CDD:275380	7/23 (30%)
		P-loop_NTPase	993..1211	CDD:304359	58/273 (21%)
		COR	1230..1471	CDD:292713
		STYKc	1796..2092	CDD:214568
		STKc_LRRK	1801..2095	CDD:270902
AT1G17230	NP_001322898.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	138	1.000	Inparanoid score	I1805
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.050