DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lrrk and AT1G12460

DIOPT Version :9

Sequence 1:	NP_001262772.1	Gene:	Lrrk / 42447	FlyBaseID:	FBgn0038816	Length:	2513	Species:	Drosophila melanogaster
Sequence 2:	NP_172708.1	Gene:	AT1G12460 / 837803	AraportID:	AT1G12460	Length:	882	Species:	Arabidopsis thaliana

Alignment Length:	1009	Identity:	201/1009 - (19%)
Similarity:	348/1009 - (34%)	Gaps:	336/1009 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly  1265 VTEQMRLHNYKSFRDAAELQQATTWCHENGVLLHYDDATLRDYYFLDP--QW-------LCDMLA 1320
            ::|:..|..:|............:|..:..:...::..|.....|:|.  .|       |...|:
plant    24 ISERDILLQFKGSISDDPYNSLASWVSDGDLCNSFNGITCNPQGFVDKIVLWNTSLAGTLAPGLS 88

  Fly  1321 HVVTVREINPFAP--TGVMKLD--DLQMLFRSVQVQGNGNRSYIVSLLNKFE----VALTWDSRT 1377
            ::..:|.:|.|..  ||.:.||  .||.|: ::.|..|.....|...:::..    :.|:.:..|
plant    89 NLKFIRVLNLFGNRFTGNLPLDYFKLQTLW-TINVSSNALSGPIPEFISELSSLRFLDLSKNGFT 152

  Fly  1378 LLIPSLLPSQEAATPNSGSTVKLSQRSRGRSL------GCSVSQEVNLNNLI-----YEQ----- 1426
            ..||.             |..|...:::..||      |...:..||.|||:     |..
plant   153 GEIPV-------------SLFKFCDKTKFVSLAHNNIFGSIPASIVNCNNLVGFDFSYNNLKGVL 204

  Fly  1427 ---------------RSAPSSSSSSASVSQGLRRILL--------------------MTYFPSGF 1456
                           |:...|...|..:.:..|.||:                    :||| :..
plant   205 PPRICDIPVLEYISVRNNLLSGDVSEEIQKCQRLILVDLGSNLFHGLAPFAVLTFKNITYF-NVS 268

  Fly  1457 WSRL---ITRILADEQIIEAI------------RGVYMASQDYADFDLRTSLEQDTQWNLWQTGL 1506
            |:|.   |..|:...:.:|.:            .|| |..:.....||.::....:
plant   269 WNRFGGEIGEIVDCSESLEFLDASSNELTGRIPTGV-MGCKSLKLLDLESNKLNGS--------- 323

  Fly  1507 ALYYGPILIFKIWEVP--FQKTERTQPFRTDGNRFKLKQDGIWSDVNLSSSSILEVYFPLYEVNI 1569
                          :|  ..|.|.....|...|..    ||: ...::.|...|:| ..|:.:|
plant   324 --------------IPGSIGKMESLSVIRLGNNSI----DGV-IPRDIGSLEFLQV-LNLHNLN- 367

  Fly  1570 SQEVDDNERQLLAEIRPHMSQVAKLLALTVDHIDLLLEDWYPSLGTRFVHTSEGRFLITRLVLCP 1634
                      |:.|:...:|....||.|.|...||                 ||:  |::.:|..
plant   368 ----------LIGEVPEDISNCRVLLELDVSGNDL-----------------EGK--ISKKLLNL 403

  Fly  1635 RCLWKLQLQQNNEPSDREVPPVGCNRP-------SRSSRRGAGAYFLHGVGDPGEDGALNVFSAY 1692
            ..:..|.|.:|.  .:..:||...|..       |::|..|.         .|...|:||..: :
plant   404 TNIKILDLHRNR--LNGSIPPELGNLSKVQFLDLSQNSLSGP---------IPSSLGSLNTLT-H 456

  Fly  1693 LNATARRERRSEDSLGAGSDADSGVGP--------DSAGSSRNTSVDGHPGYHLPDNS------- 1742
            .|.       |.::|       |||.|        .|:..|.|..:.|.| ...|.||
plant   457 FNV-------SYNNL-------SGVIPPVPMIQAFGSSAFSNNPFLCGDP-LVTPCNSRGAAAKS 506

  Fly  1743 ----------------------NVCYAWMI---------EECILSVYNQSKISCPVHLEQSMAQL 1776
                                  .||....:         :|.||:|......|   .::.|...:
plant   507 RNSDALSISVIIVIIAAAVILFGVCIVLALNLRARKRRKDEEILTVETTPLAS---SIDSSGVII 568

  Fly  1777 APDVIFA-DIPDKH---TIPSECII-KGSLLGRGAFGFVFKANCKVRGARSFK---PVAMKMLQP 1833
            ...|:|: ::|.|:   ...::.:: |.:::|.|:.|.|::|        ||:   .:|:|.|:.
plant   569 GKLVLFSKNLPSKYEDWEAGTKALLDKENIIGMGSIGSVYRA--------SFEGGVSIAVKKLET 625

  Fly  1834 VPPGARAKESALMAFKVAVGKWDRDPLQHSCKAYCTARQELAVLLTLKHPNIVPLVGICI-KPLA 1897
            :......:|                           ..||:..|..|:|||:....|... ..:.
plant   626 LGRIRNQEE---------------------------FEQEIGRLGGLQHPNLSSFQGYYFSSTMQ 663

  Fly  1898 LVL-ELAPLGGL-DAL-LRHYRRSGAHMGP-----HTFQTLVLQAARAIEYLH---RRRIIYRDL 1951
            |:| |..|.|.| |.| ||.:..:.:..|.     |....:.|..|:|:.:||   :..|::.::
plant   664 LILSEFVPNGSLYDNLHLRIFPGTSSSYGNTDLNWHRRFQIALGTAKALSFLHNDCKPAILHLNV 728

  Fly  1952 KSENVLVWELPQPHTEDSPRNLVHIKIADYGISR----QTAPSGAKGFGGTEGFMAPEIIRYNGE 2012
            ||.|:|:.|            ....|::|||:.:    ..:....|.|....|::|||:.:.:
plant   729 KSTNILLDE------------RYEAKLSDYGLEKFLPVMDSFGLTKKFHNAVGYIAPELAQQS-- 779

  Fly  2013 EEYTEKVDCFSFGMFIYENISLRQPFEGHESIKECIL-EGSRPALTQRETQFPTCCLD------- 2069
            ...:||.|.:|:|:.:.|.::.|:|.|.....:..|| :..|..|   ||...:.|.|
plant   780 LRASEKCDVYSYGVVLLELVTGRKPVESPSENQVLILRDYVRDLL---ETGSASDCFDRRLREFE 841

  Fly  2070 ---------LMVLCWHEQPRRRPTASQIVSILSA 2094
                     |.:||..|.|.:||:.:::|.:|.:
plant   842 ENELIQVMKLGLLCTSENPLKRPSMAEVVQVLES 875

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lrrk	NP_001262772.1	Ank_2	111..200	CDD:289560
		ANK	146..286	CDD:238125
		ANK repeat	146..177	CDD:293786
		Ank_4	179..232	CDD:290365
		ANK repeat	179..209	CDD:293786
		Ank_2	216..389	CDD:289560
		ANK	361..477	CDD:238125
		ANK repeat	361..390	CDD:293786
		Ank_2	364..464	CDD:289560
		ANK repeat	406..435	CDD:293786
		ANK repeat	437..464	CDD:293786
		LRR_8	<544..580	CDD:290566
		leucine-rich repeat	547..569	CDD:275380
		LRR_8	569..629	CDD:290566
		leucine-rich repeat	570..595	CDD:275380
		leucine-rich repeat	596..618	CDD:275380
		leucine-rich repeat	619..641	CDD:275380
		leucine-rich repeat	642..676	CDD:275380
		leucine-rich repeat	677..730	CDD:275380
		LRR_8	729..788	CDD:290566
		leucine-rich repeat	731..754	CDD:275380
		LRR_8	855..933	CDD:290566
		leucine-rich repeat	855..901	CDD:275380
		leucine-rich repeat	902..924	CDD:275380
		leucine-rich repeat	925..949	CDD:275380
		P-loop_NTPase	993..1211	CDD:304359
		COR	1230..1471	CDD:292713	51/276 (18%)
		STYKc	1796..2092	CDD:214568	78/332 (23%)
		STKc_LRRK	1801..2095	CDD:270902	78/330 (24%)
AT1G12460	NP_172708.1	PLN00113	6..875	CDD:215061	201/1007 (20%)
		LRRNT_2	25..64	CDD:285463	5/38 (13%)
		leucine-rich repeat	93..116	CDD:275380	8/22 (36%)
		leucine-rich repeat	117..140	CDD:275380	4/23 (17%)
		leucine-rich repeat	141..165	CDD:275380	6/36 (17%)
		leucine-rich repeat	166..189	CDD:275380	5/22 (23%)
		LRR_RI	194..417	CDD:238064	48/285 (17%)
		leucine-rich repeat	214..237	CDD:275380	3/22 (14%)
		leucine-rich repeat	238..261	CDD:275380	2/22 (9%)
		leucine-rich repeat	262..285	CDD:275380	7/23 (30%)
		leucine-rich repeat	286..309	CDD:275380	4/23 (17%)
		leucine-rich repeat	310..333	CDD:275380	4/45 (9%)
		leucine-rich repeat	334..357	CDD:275380	5/27 (19%)
		leucine-rich repeat	358..381	CDD:275380	7/34 (21%)
		leucine-rich repeat	382..405	CDD:275380	10/41 (24%)
		leucine-rich repeat	406..429	CDD:275380	6/24 (25%)
		leucine-rich repeat	430..453	CDD:275380	6/31 (19%)
		STKc_IRAK	599..876	CDD:270968	78/329 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	138	1.000	Inparanoid score	I1805
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.050