DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lrrk and ERL1

DIOPT Version :9

Sequence 1:	NP_001262772.1	Gene:	Lrrk / 42447	FlyBaseID:	FBgn0038816	Length:	2513	Species:	Drosophila melanogaster
Sequence 2:	NP_201029.1	Gene:	ERL1 / 836344	AraportID:	AT5G62230	Length:	966	Species:	Arabidopsis thaliana

Alignment Length:	1029	Identity:	213/1029 - (20%)
Similarity:	356/1029 - (34%)	Gaps:	351/1029 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly  1295 VLLHYDDATLRDYYFLDPQW---LCDMLAH-VVTVR--------EINPFAPTGVMKLDDLQMLFR 1347
            :||.:||....|..    .|   .||.::: ||::.        ||:|       .:.||:.| :
plant    46 MLLDWDDVHNSDLC----SWRGVFCDNVSYSVVSLNLSSLNLGGEISP-------AIGDLRNL-Q 98

  Fly  1348 SVQVQGN----------GNRSYIVSL--------------LNKFEVALTWDSRTLLIPSLLPSQE 1388
            |:.:|||          ||.:.:|.|              ::|.:...|.:.:...:...:|:..
plant    99 SIDLQGNKLAGQIPDEIGNCASLVYLDLSENLLYGDIPFSISKLKQLETLNLKNNQLTGPVPATL 163

  Fly  1389 AATPN-----------SGSTVKLSQRS--------RGRSLGCSVSQ-----------EVNLNNLI 1423
            ...||           :|...:|...:        ||..|..::|.           :|..|||
plant   164 TQIPNLKRLDLAGNHLTGEISRLLYWNEVLQYLGLRGNMLTGTLSSDMCQLTGLWYFDVRGNNL- 227

  Fly  1424 YEQRSAPSSSSSSASVSQGLRRILLMTY--------FPSGFWSRLITRILADEQIIEAIRGVYMA 1480
              ..:.|.|..:..|.     :||.::|        :..|| .::.|..|...::...|..|...
plant   228 --TGTIPESIGNCTSF-----QILDISYNQITGEIPYNIGF-LQVATLSLQGNRLTGRIPEVIGL 284

  Fly  1481 SQDYADFDLRTSLEQDTQ---------WNLWQTGLALYYGPILIFKIWEVPFQKTERTQPFRTD- 1535
            .|..|..||     .|.:         .||..||....:|.:|              |.|..::
plant   285 MQALAVLDL-----SDNELVGPIPPILGNLSFTGKLYLHGNML--------------TGPIPSEL 330

  Fly  1536 GNRFKLKQDGIWSDVNLSSSSILEVYFP-------LYEVNISQEVDDNERQLLAEIRPHMSQVAK 1593
            ||..:|      |.:.|:.:.::....|       |:|:|::     |.| |:..|..::|..|.
plant   331 GNMSRL------SYLQLNDNKLVGTIPPELGKLEQLFELNLA-----NNR-LVGPIPSNISSCAA 383

  Fly  1594 LLALTVDHIDLL---LEDWYPSLGTRFVHTSEGRFLITRLVLCPRCLWKLQLQQNNEPSDREVPP 1655
            |....| |.:||   :...:.:||:                     |..|.|..||...  ::|.
plant   384 LNQFNV-HGNLLSGSIPLAFRNLGS---------------------LTYLNLSSNNFKG--KIPV 424

  Fly  1656 -----VGCNRPSRSSRRGAGAYFLHGVGDPGEDGALNVFSAYLNATARRE---RRSEDSLGAGSD 1712
                 :..::...|....:|:..| .:||......||:...:|:.....|   .||...:....:
plant   425 ELGHIINLDKLDLSGNNFSGSIPL-TLGDLEHLLILNLSRNHLSGQLPAEFGNLRSIQMIDVSFN 488

  Fly  1713 ADSGVGPDSAGSSRNTS--VDGHPGYH--LPD---------NSNV-------------------- 1744
            ..|||.|...|..:|.:  :..:...|  :||         |.||
plant   489 LLSGVIPTELGQLQNLNSLILNNNKLHGKIPDQLTNCFTLVNLNVSFNNLSGIVPPMKNFSRFAP 553

  Fly  1745 ---------CYAWMIEEC----------------------------ILSVY---NQSKISCPVHL 1769
                     |..|:...|                            .|:||   .|.||     |
plant   554 ASFVGNPYLCGNWVGSICGPLPKSRVFSRGALICIVLGVITLLCMIFLAVYKSMQQKKI-----L 613

  Fly  1770 EQSMAQ---------LAPDVIFADIPDKHTIPSECIIKGSLLGRGAFGFVFKANCKVRGARSFKP 1825
            :.|..|         |..|:......|...: :|.:.:..::|.||...|:|  |.::.:|   |
plant   614 QGSSKQAEGLTKLVILHMDMAIHTFDDIMRV-TENLNEKFIIGYGASSTVYK--CALKSSR---P 672

  Fly  1826 VAMKMLQPVPPGARAKESALMAFKVAVGKWDRDPLQHSCKAYCTARQELAVLLTLKHPNIVPLVG 1890
            :|:|.|....|                         |:.:.:.|   ||..:.:::|.|||.|.|
plant   673 IAIKRLYNQYP-------------------------HNLREFET---ELETIGSIRHRNIVSLHG 709

  Fly  1891 ICIKPLA--LVLELAPLGGLDALLRHYRRSGAHMGPHTFQTLVLQAARAIEYLHR---RRIIYRD 1950
            ..:.|..  |..:....|.|..|| |.......:...|...:.:.||:.:.|||.   .|||:||
plant   710 YALSPTGNLLFYDYMENGSLWDLL-HGSLKKVKLDWETRLKIAVGAAQGLAYLHHDCTPRIIHRD 773

  Fly  1951 LKSENVLVWELPQPHTEDSPRNLVHIKIADYGISRQTAPSGAKGFG---GTEGFMAPEIIRYNGE 2012
            :||.|:|:.|..:.|            ::|:||::....|......   ||.|::.||   |...
plant   774 IKSSNILLDENFEAH------------LSDFGIAKSIPASKTHASTYVLGTIGYIDPE---YART 823

  Fly  2013 EEYTEKVDCFSFGMFIYENISLRQPFEGHESIKECIL---------EGSRPALTQRETQFPTCCL 2068
            ....||.|.:|||:.:.|.::.::..:...::.:.||         |...|.:|       ..|:
plant   824 SRINEKSDIYSFGIVLLELLTGKKAVDNEANLHQLILSKADDNTVMEAVDPEVT-------VTCM 881

  Fly  2069 D---------LMVLCWHEQPRRRPTASQIVSILSA--PECIHLLDVVAMPHSEK 2111
            |         |.:||....|..|||..::..:|.:  |.......:.::.||.|
plant   882 DLGHIRKTFQLALLCTKRNPLERPTMLEVSRVLLSLVPSLQVAKKLPSLDHSTK 935

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lrrk	NP_001262772.1	Ank_2	111..200	CDD:289560
		ANK	146..286	CDD:238125
		ANK repeat	146..177	CDD:293786
		Ank_4	179..232	CDD:290365
		ANK repeat	179..209	CDD:293786
		Ank_2	216..389	CDD:289560
		ANK	361..477	CDD:238125
		ANK repeat	361..390	CDD:293786
		Ank_2	364..464	CDD:289560
		ANK repeat	406..435	CDD:293786
		ANK repeat	437..464	CDD:293786
		LRR_8	<544..580	CDD:290566
		leucine-rich repeat	547..569	CDD:275380
		LRR_8	569..629	CDD:290566
		leucine-rich repeat	570..595	CDD:275380
		leucine-rich repeat	596..618	CDD:275380
		leucine-rich repeat	619..641	CDD:275380
		leucine-rich repeat	642..676	CDD:275380
		leucine-rich repeat	677..730	CDD:275380
		LRR_8	729..788	CDD:290566
		leucine-rich repeat	731..754	CDD:275380
		LRR_8	855..933	CDD:290566
		leucine-rich repeat	855..901	CDD:275380
		leucine-rich repeat	902..924	CDD:275380
		leucine-rich repeat	925..949	CDD:275380
		P-loop_NTPase	993..1211	CDD:304359
		COR	1230..1471	CDD:292713	49/249 (20%)
		STYKc	1796..2092	CDD:214568	77/321 (24%)
		STKc_LRRK	1801..2095	CDD:270902	78/321 (24%)
ERL1	NP_201029.1	PLN00113	12..916	CDD:215061	209/1008 (21%)
		leucine-rich repeat	73..96	CDD:275380	7/29 (24%)
		leucine-rich repeat	97..120	CDD:275380	7/23 (30%)
		leucine-rich repeat	121..144	CDD:275380	3/22 (14%)
		leucine-rich repeat	145..168	CDD:275380	2/22 (9%)
		leucine-rich repeat	169..192	CDD:275380	2/22 (9%)
		leucine-rich repeat	193..216	CDD:275380	4/22 (18%)
		leucine-rich repeat	217..240	CDD:275380	6/25 (24%)
		leucine-rich repeat	241..263	CDD:275380	5/27 (19%)
		leucine-rich repeat	266..287	CDD:275380	4/20 (20%)
		leucine-rich repeat	288..311	CDD:275380	6/27 (22%)
		leucine-rich repeat	312..335	CDD:275380	8/36 (22%)
		leucine-rich repeat	336..359	CDD:275380	4/28 (14%)
		leucine-rich repeat	360..383	CDD:275380	8/28 (29%)
		leucine-rich repeat	384..407	CDD:275380	6/23 (26%)
		leucine-rich repeat	408..431	CDD:275380	6/24 (25%)
		leucine-rich repeat	432..455	CDD:275380	5/23 (22%)
		leucine-rich repeat	456..479	CDD:275380	4/22 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	138	1.000	Inparanoid score	I1805
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.050